Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mariël Brok"'
Autor:
Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients re
Externí odkaz:
https://doaj.org/article/6e17129946ec4b3cabd8153ddce619c9
Autor:
Michael T Meister, Marian J A Groot Koerkamp, Terezinha de Souza, Willemijn B Breunis, Ewa Frazer‐Mendelewska, Mariël Brok, Jeff DeMartino, Freek Manders, Camilla Calandrini, Hinri H D Kerstens, Alex Janse, M Emmy M Dolman, Selma Eising, Karin P S Langenberg, Marc van Tuil, Rutger R G Knops, Sheila Terwisscha van Scheltinga, Laura S Hiemcke‐Jiwa, Uta Flucke, Johannes H M Merks, Max M van Noesel, Bastiaan B J Tops, Jayne Y Hehir‐Kwa, Patrick Kemmeren, Jan J Molenaar, Marc van de Wetering, Ruben van Boxtel, Jarno Drost, Frank C P Holstege
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-23 (2022)
Abstract Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high‐risk patients. Discovery of new therapies would benefit from addi
Externí odkaz:
https://doaj.org/article/bfe59c6efb18489cb65ad4d76f02464c
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 10, Pp 1-16 (2020)
Abstract Protein–DNA interactions are dynamic, and these dynamics are an important aspect of chromatin‐associated processes such as transcription or replication. Due to a lack of methods to study on‐ and off‐rates across entire genomes, prote
Externí odkaz:
https://doaj.org/article/1b744990507c44a588fd58f2853d4b9b
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100020- (2020)
Summary: Transcription factors are important regulators of cell fate and function. Knowledge about where transcription factors are bound in the genome is crucial for understanding their function. A common method to study protein-DNA interactions is c
Externí odkaz:
https://doaj.org/article/9d74e31b7cb6410bb2405975e1bbd800
Autor:
Jeff DeMartino, Michael T. Meister, Lindy Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Publikováno v:
bioRxiv
BioRxiv
BioRxiv
Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin which is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients remains di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bb156f85717f807999957a119c863
https://doi.org/10.1101/2022.07.15.497944
https://doi.org/10.1101/2022.07.15.497944
Autor:
Frank C. P. Holstege, Jarno Drost, Ruben van Boxtel, Marc van de Wetering, Jan J. Molenaar, Patrick Kemmeren, Jayne Y. Hehir-Kwa, Bastiaan B. J. Tops, Max M. van Noesel, Johannes H. M. Merks, Uta Flucke, Laura S. Hiemcke-Jiwa, Sheila Terwisscha van Scheltinga, Rutger R. G. Knops, Marc van Tuil, Karin P. S. Langenberg, Selma Eising, M. Emmy M. Dolman, Alex Janse, Hinri H. D. Kerstens, Camilla Calandrini, Freek Manders, Jeff DeMartino, Mariël Brok, Ewa Frazer-Mendelewska, Willemijn B. Breunis, Terezinha de Souza, Marian J. A. Groot Koerkamp, Michael T. Meister
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40d6c1a1dd7c26ccd4397c1f88597b5e
https://doi.org/10.15252/rc.2022721694
https://doi.org/10.15252/rc.2022721694
Publikováno v:
Molecular Pharmacology, 61, 659-666. American Society for Pharmacology and Experimental Therapeutics
The therapeutic potential of the highly active anticancer agent cisplatin is severely limited by the occurrence of cellular resistance. A better understanding of the molecular pathways involved in cisplatin-induced cell death could potentially indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a7c24eed166531f110b08edcd90ba2
https://doi.org/10.1124/mol.61.3.659
https://doi.org/10.1124/mol.61.3.659
Autor:
Kees Nooter, Erik A.C. Wiemer, Mariël Brok, Antonius W. M. Boersma, Gerrit Stoter, Herman Burger, Hans van Tol
Publikováno v:
Blood, 104, 2940-2942. American Society of Hematology
Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a11c34546f0a8bcbd55e69943dbd9d
https://doi.org/10.1182/blood-2004-04-1398
https://doi.org/10.1182/blood-2004-04-1398
Autor:
Mariël Brok, Jaap Verweij, Alex Sparreboom, Ernst A. de Bruijn, Erik A.C. Wiemer, Kees Nooter, Herman Burger, Gert De Boeck, Hans van Tol, Gunther Guetens
Publikováno v:
Scopus-Elsevier
Cancer biology & therapy
Cancer biology & therapy
Imatinib mesylate is a selective tyrosine kinase inhibitor that is successfully used in the treatment of Philadelphia-positive chronic and acute leukaemia's, and gastrointestinal stromal tumors. We investigated whether the intended chronic oral admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f84dd6ae81250e2861c274873338c9
https://pubmed.ncbi.nlm.nih.gov/15970668
https://pubmed.ncbi.nlm.nih.gov/15970668
Autor:
Jaap Brouwer, Antonius W. M. Boersma, Hans den Dulk, Gerrit Stoter, Kees Nooter, Jourica A. Brandsma, Paul W. Schenk, Mariël Brok, Herman Burger
Publikováno v:
Molecular Pharmacology, 64(2), 259-268. American Society for Pharmacology and Experimental Therapeutics
The therapeutic potential of antitumor drugs is seriously limited by the manifestation of cellular drug resistance. We used the budding yeast Saccharomyces cerevisiae as a model system to identify novel mechanisms of resistance to one of the most act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54902b223219b7fc9b6bdf46b187f224
https://pure.eur.nl/en/publications/9fefdf4b-8589-495c-a956-987f48a96a33
https://pure.eur.nl/en/publications/9fefdf4b-8589-495c-a956-987f48a96a33