Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Marharyta Kolcheva"'
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Akademický článek
Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
Autor: Kristyna Skrenkova, Katarina Hemelikova, Marharyta Kolcheva, Stepan Kortus, Martina Kaniakova, Barbora Krausova, Martin Horak
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an essential role in mediating excitatory neurotransmission in the mammalian central nervous system (CNS). Functional NMDARs are tetramers composed of GluN1
Externí odkaz: https://doaj.org/article/f472834e09084930aa0fbf6223cd8223
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3
Akademický článek
Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists
Autor: Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Publikováno v: Biomolecules, Vol 11, Iss 1, p 3 (2020)
Alzheimer’s disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists. Drugs targeting only one pathol
Externí odkaz: https://doaj.org/article/d6ee28dbc6f147f48bce851d85867db0
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4
Structure-guided design of N-methylpropargylamino-quinazoline derivatives as multipotent agents for the treatment of Alzheimer's disease
Autor: Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, Tomas Rousar, Lukas Prchal, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Daniela Tosnerova, Galina Karabanovich, Vladimir Finger, Ondrej Soukup, Martin Horak, Jan Korabecny
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9124
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cb799254ac08c27aef258d2c563f51
https://ruj.uj.edu.pl/xmlui/handle/item/312616
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5
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors
Autor: Marharyta Kolcheva, Marek Ladislav, Jakub Netolicky, Stepan Kortus, Kristyna Rehakova, Barbora Hrcka Krausova, Katarina Hemelikova, Anna Misiachna, Anna Kadkova, Martin Klima, Dominika Chalupska, Martin Horak
Publikováno v: Neuropharmacology. 222:109297
N-methyl-D-aspartate receptors (NMDARs) play an essential role in excitatory neurotransmission in the mammalian brain, and their physiological importance is underscored by the large number of pathogenic mutations that have been identified in the rece
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e959c510f717f7f02d860042e67e638
https://doi.org/10.1016/j.neuropharm.2022.109297
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6
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
Autor: Rafael Dolezal, Kristina Hakenova, Jiri Damborsky, Marharyta Kolcheva, Karel Vales, Jan Korabecny, Lada Cejkova, Marketa Chvojkova, Anna Misiachna, Martin Novák, Ondrej Soukup, Lukas Prchal, Lukas Gorecki, Jana Zdarova Karasova, Martin Horak, Stepan Kortus
Publikováno v: European journal of medicinal chemistry. 219
Tacrine is a classic drug whose efficacy against neurodegenerative diseases is still shrouded in mystery. It seems that besides its inhibitory effect on cholinesterases, the clinical benefit is co-determined by NMDAR-antagonizing activity. Our previo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfc3e0ae05793e4357ad120bae0352e
https://pubmed.ncbi.nlm.nih.gov/33892271
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7
Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors
Autor: Martina Kaniakova, Barbora Krausova, Sarka Danacikova, Matej Hotovec, Katarina Hemelikova, Petra Barackova, Martin Horak, Anna Misiachna, Stepan Kortus, Kristyna Rehakova, Marharyta Kolcheva
Publikováno v: Neuropharmacology. 189
N-methyl- d -aspartate receptors (NMDARs) play an essential role in regulating glutamatergic neurotransmission. Recently, pathogenic missense mutations were identified in genes encoding NMDAR subunits; however, their effect on NMDAR activity is often
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ae51bdc5c6968e0829a5dc7432521e
https://pubmed.ncbi.nlm.nih.gov/33773999
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8
The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors
Autor: Barbora Krausova, Jae man Song, Stepan Kortus, Katarina Hemelikova, Young Ho Suh, Marharyta Kolcheva, Jakub Netolicky, Martin Horak, Jan Korabecny, Tomas Kucera, Martina Kaniakova, Kristyna Skrenkova
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Although numerous pathogenic mutations have been identified in various subunits of N-methyl-D-aspartate receptors (NMDARs), ionotropic glutamate receptors that are central to glutamatergic neurotransmission, the functional effects of these mutations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1c16669e528f2bb27b698274128b76
https://doi.org/10.1038/s41598-020-75646-w
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9
Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
Autor: Martin Horak, Martina Kaniakova, Kristyna Skrenkova, Katarina Hemelikova, Barbora Krausova, Stepan Kortus, Marharyta Kolcheva
Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an essential role in mediating excitatory neurotransmission in the mammalian central nervous system (CNS). Functional NMDARs are tetramers composed of GluN1, GluN2A-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2ab76a27a8d7bf51af8546efc1abe
https://pubmed.ncbi.nlm.nih.gov/31444392
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10
Lectins modulate the functional properties of GluN1/GluN3-containing NMDA receptors
Autor: Katarina Hemelikova, Marharyta Kolcheva, Kristyna Skrenkova, Martin Horak, Martina Kaniakova
Publikováno v: Neuropharmacology. 157
N-methyl-d-aspartate receptors (NMDARs) play an essential role in excitatory neurotransmission within the mammalian central nervous system (CNS). NMDARs are heteromultimers containing GluN1, GluN2, and/or GluN3 subunits, thus giving rise to a wide va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8a2f21a2dcd3458c357941ab4f3db9
https://pubmed.ncbi.nlm.nih.gov/31202607
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