Výsledky vyhledávání - "Marguerite R. Kelher"

A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitroshort‐termincubation with sex hormones

Autor: Jamie B. Hadley, Marguerite R. Kelher, Angelo D'Alessandro, Fabia Gamboni, Kirk Hansen, Julia Coleman, Kenneth Jones, Mitchell Cohen, Ernest E. Moore, Anirban Banerjee, Christopher C. Silliman

Publikováno v: Transfusion

BACKGROUND: Platelets are part of innate immunity and comprise the cellular portion of hemostasis. Platelets express sex hormone receptors on their plasma membrane and sex hormones can alter their function in vitro. Little is known about how age and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fe44261ddfac2988ef88cada7b6a60
https://doi.org/10.1111/trf.17165

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BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY

Autor: Margot, DeBot, Andrew P, Eitel, Ernest E, Moore, Angela, Sauaia, Patrick, Lutz, Terry R, Schaid, Jamie B, Hadley, Daniel J, Kissau, Mitchell J, Cohen, Marguerite R, Kelher, Christopher C, Silliman

Publikováno v: Shock. 58:492-497

Background: Blood type O is the most common blood type and has lower von Willebrand factor (vWF) levels (25%-35% lower than non-O blood types). von Willebrand factor is important for initiating platelet attachment and binding factor VIII. We hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2b10aa6e8f360f8fdc95e4df7713a
https://doi.org/10.1097/shk.0000000000002013

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Hormones, age, and sex affect platelet responsiveness in vitro

Autor: Jamie B. Hadley, Marguerite R. Kelher, Julia R. Coleman, Kathleen K. Kelly, Larry J. Dumont, Orlando Esparza, Anirban Banerjee, Mitchell J. Cohen, Kenneth Jones, Christopher C. Silliman

Publikováno v: Transfusion. 62:1882-1893

Female sex confers a survival advantage following severe injury in the setting of trauma-induced coagulopathy, with female platelets having heightened responsiveness likely due to estrogen. The effects of testosterone on platelet biology are unknown,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e408da094a1763058ed0c553ce24db1
https://doi.org/10.1111/trf.17054

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The α-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro

Autor: Shaun Bevers, Marguerite R. Kelher, Christopher C. Silliman, Kirk C. Hansen, Alexander P. Morton, Ernest E. Moore, Arsen Ghasabyan, Anirban Banerjee, Jamie B. Hadley, Mitchell S Cohen, Monika Dzieciatkowska

Publikováno v: J Trauma Acute Care Surg

Severe injury predisposes patients to trauma-induced coagulopathy, which may be subdivided by the state of fibrinolysis. Systemic hyperfibrinolysis (HF) occurs in approximately 25% of these patients with mortality as high as 70%. Severe injury also c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c02b924edbd42122228b3662c98da47
https://doi.org/10.1097/ta.0000000000003410

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28‐day thawed plasma maintains α 2 ‐antiplasmin levels and inhibits tPA‐induced fibrinolysis

Autor: Julia R. Coleman, Benjamin R. Huebner, Geoffrey R. Nunns, Marguerite R. Kelher, Anirban Banerjee, Christopher C. Silliman, Ernest E. Moore, Gregory R. Stettler, Hunter B. Moore

Publikováno v: Vox Sanguinis. 116:181-189

Introduction Evidence supports the use of plasma-first resuscitation in the treatment of trauma-induced coagulopathy (TIC). While thawed plasma (TP) has logistical benefits, the ability of plasma proteins to attenuate fibrinolysis and correct TIC rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b0f971bf34427b7b5881a25c35dd3fb
https://doi.org/10.1111/vox.12997

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Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy

Autor: Julia R. Coleman, Mitchell J. Cohen, Marguerite R. Kelher, Erik D. Peltz, Angela Sauaia, Ernest E. Moore, Anirban Banerjee, Christopher C. Silliman, Jason M. Samuels

Publikováno v: J Trauma Acute Care Surg

BACKGROUND: Females are hypercoagulable and have survival benefit in trauma-induced coagulopathy (TIC). The mechanism for this sex-specific hypercoagulability is unknown. Platelets and platelet function are central in providing hemostatic potential a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06fcf773f040c0f382b3117fdb0bfa9
https://doi.org/10.1097/ta.0000000000002398

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