Výsledky vyhledávání - "Marguerite Hutchinson"

Phase 1b/2 study of pexidartinib (PEX) in combination with radiation therapy (XRT) and temozolomide (TMZ) in newly diagnosed glioblastoma

Autor: Karthik Sonty, Michael Pelayo, Tobias Walbert, Eric T. Wong, Fabio M. Iwamoto, Brett Johnson, Maciej M. Mrugala, Howard Colman, David A. Karlin, Vinay K. Puduvalli, Jeffrey Raizer, David A. Reardon, Henry Hsu, Marguerite Hutchinson, Marc C. Chamberlain, Scott R. Plotkin

Publikováno v: Journal of Clinical Oncology. 36:2015-2015

2015Background: PEX is an oral small molecule inhibitor of KIT and CSF1 receptor expressed on microglia, blood vessels, and glioblastoma (GBM) tumor cells. PEX achieved good tissue exposure in a pr...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee6534c9cf9801301a269c73d51cce6
https://doi.org/10.1200/jco.2018.36.15_suppl.2015

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ACTR-20. INITIAL RESULTS OF PLX108-08: AN OPEN LABEL PHASE 1B/2 STUDY OF ORALLY ADMINISTERED PEXIDARTINIB (PLX3397) IN COMBINATION WITH RADIATION THERAPY AND TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA

Autor: Vinay K. Puduvalli, Tobias Walbert, Scott R. Plotkin, Bill Welbourn, Marc C. Chamberlain, Henry Hsu, Karthik Sonty, Jeffrey Raizer, David A. Reardon, Howard Colman, Michael Pelayo, David A. Karlin, Brett Johnson, Eric T. Wong, Fabio M. Iwamoto, Marguerite Hutchinson

Publikováno v: Neuro-Oncology. 18:vi6-vi6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66cdb692ee4db22c7ee34374f9bbae0
https://doi.org/10.1093/neuonc/now212.019

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Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (Pexidartinib/PLX3397) with an anti PD-1 antibody (Pembrolizumab) to treat advanced, solid tumors

Autor: Amita Patnaik, Peter D. Eisenberg, Jasgit C. Sachdev, Amy M. Weise, Archie N. Tse, Marguerite Hutchinson, Ireene Aromin, Brian West, Sandra Tong, Antoni Ribas, Siwen Hu-Lieskovan

Publikováno v: Journal of Clinical Oncology. 34:TPS11618-TPS11618

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee5af66b26bae41b5cd4d5fa5c5e356
https://doi.org/10.1200/jco.2016.34.15_suppl.tps11618

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Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors

Autor: Zev A. Wainberg, Siwen Hu-Lieskovan, Sandra Tong, Amita Patnaik, Marguerite Hutchinson, Jasgit C. Sachdev, Ireene Aromin, Amy Weise, David Ross Kaufman, Peter D. Eisenberg

Publikováno v: Annals of Oncology. 26:viii5

TPS465 Background: Tumor-associated macrophages (TAMs) support tumor growth and cause tumor resistance to chemotherapy and radiation therapy; myeloid-derived suppressor cells (MDSCs) suppress anti-tumor immunity and cause resistance to PD-1 inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d018d0a10e8b500c2f72eac78cd2e79e
https://doi.org/10.1093/annonc/mdv514.08

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