Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Margriet Ouwens"'
Autor:
Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove, Bruno Lapauw
Publikováno v:
Endocrine Connections, Vol 8, Iss 9, Pp 1294-1301 (2019)
Purpose: Obese subjects with nonalcoholic fatty liver disease (NAFLD) are more prone to develop additional metabolic disturbances such as systemic insulin resistance (IR) and type 2 diabetes. NAFLD is defined by hepatic steatosis, lobular inflammatio
Externí odkaz:
https://doaj.org/article/0e562b078c5a4d13b56173ac46e82055
Autor:
Meike Klier, Simone Gorressen, Marc-Andre Urbahn, David Barbosa, Margriet Ouwens, Jens W. Fischer, Margitta Elvers
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Phospholipase D1 is a regulator of tumor necrosis factor-α expression and release upon LPS-induced sepsis and following myocardial infarction (MI). Lack of PLD1 leads to a reduced TNF-α mediated inflammatory response and to enhanced infarct size wi
Externí odkaz:
https://doaj.org/article/770335fccbc747c4b5b6db508ce1108f
Autor:
Jessica I. Selig, H. Viviana Krug, Caroline Küppers, D. Margriet Ouwens, Felix A. Kraft, Elena Adler, Sebastian J. Bauer, Artur Lichtenberg, Payam Akhyari, Mareike Barth
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Diabetes and its major key determinants insulin resistance and hyperglycemia are known risk factors for calcific aortic valve disease (CAVD). The processes leading to molecular and structural alterations of the aortic valve are yet not fully understo
Externí odkaz:
https://doaj.org/article/952065509df84226b5fa55f606829115
Autor:
Jessica I. Selig, Joana Boulgaropoulos, Naima Niazy, D. Margriet Ouwens, Karlheinz Preuß, Patrick Horn, Ralf Westenfeld, Artur Lichtenberg, Payam Akhyari, Mareike Barth
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6976 (2021)
Type 2 diabetes mellitus (T2D) is one of the prominent risk factors for the development and progression of calcific aortic valve disease. Nevertheless, little is known about molecular mechanisms of how T2D affects aortic valve (AV) remodeling. In thi
Externí odkaz:
https://doaj.org/article/d25a5c2a3afb4c4f9a1bf60a3d8f0aca
Autor:
Maren Carstensen-Kirberg, Karin Röhrig, Corinna Niersmann, D Margriet Ouwens, Bengt F Belgardt, Michael Roden, Christian Herder
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213650 (2019)
Previous studies reported that secreted frizzled-related protein-5 (Sfrp5) decreases beta cell proliferation and increases fasting insulin levels, but studies on direct effects of Sfrp5 on insulin secretion and its underlying mechanisms are missing.
Externí odkaz:
https://doaj.org/article/8af7953a0e5f407fa04fba0d2678b578
Autor:
Olga Pivovarova-Ramich, Jennifer Loske, Silke Hornemann, Mariya Markova, Nicole Seebeck, Anke Rosenthal, Frederick Klauschen, José Pedro Castro, René Buschow, Tilman Grune, Volker Lange, Natalia Rudovich, D. Margriet Ouwens
Publikováno v:
Cells, Vol 10, Iss 5, p 1048 (2021)
Liver fibrosis is a critical complication of obesity-induced fatty liver disease. Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4), a novel adipokine associated with visceral obesity and insulin resistance, also contributes to lung and kidney
Externí odkaz:
https://doaj.org/article/0511f3018cd14fd6b75df1ec3e243ec7
Autor:
Mark M. Smits, Jens J. Holst, D. Margriet Ouwens, Daniël H. van Raalte, Bolette Hartmann, Lennart Tonneijck, Marcel H.A. Muskiet, A.H. Jan Danser, Mark H.H. Kramer, Jaap A. Joles
Publikováno v:
Diabetes, Obesity and Metabolism, 24(1), 115-124. Wiley-Blackwell Publishing Ltd
Muskiet, M H A, Tonneijck, L, Smits, M M, Kramer, M H H, Ouwens, D M, Hartmann, B, Holst, J J, Danser, A H J, Joles, J A & van Raalte, D H 2022, ' Postprandial renal haemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS) : A predefined substudy of a randomized, double-blind trial ', Diabetes, Obesity and Metabolism, vol. 24, no. 1, pp. 115-124 . https://doi.org/10.1111/dom.14557
Diabetes, Obesity and Metabolism, 24(1), 115-124. Wiley-Blackwell
Muskiet, M H A, Tonneijck, L, Smits, M M, Kramer, M H H, Ouwens, D M, Hartmann, B, Holst, J J, Danser, A H J, Joles, J A & van Raalte, D H 2022, ' Postprandial renal haemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS) : A predefined substudy of a randomized, double-blind trial ', Diabetes, Obesity and Metabolism, vol. 24, no. 1, pp. 115-124 . https://doi.org/10.1111/dom.14557
Diabetes, Obesity and Metabolism, 24(1), 115-124. Wiley-Blackwell
Aim: To determine the effect of the dipeptidyl peptidase-4 inhibitor linagliptin on postprandial glomerular hyperfiltration compared with the sulphonylurea glimepiride in adults with type 2 diabetes (T2D). Materials and Methods: In this predefined su
Autor:
Nils G Løvsletten, Siril S Bakke, Eili T Kase, D Margriet Ouwens, G Hege Thoresen, Arild C Rustan
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0208048 (2018)
It has previously been shown that pretreatment of differentiated human skeletal muscle cells (myotubes) with eicosapentaenoic acid (EPA) promoted increased uptake of fatty acids and increased triacylglycerol accumulation, compared to pretreatment wit
Externí odkaz:
https://doaj.org/article/5e1bf2d1e97f4c2383cfe53deeccd2b4
Autor:
Lennart Tonneijck, D. Margriet Ouwens, Mark M. Smits, Jordan Kraaijenhof, Mark H.H. Kramer, Marcel H.A. Muskiet, Daniël H. van Raalte
Publikováno v:
Kraaijenhof, J, Muskiet, M H A, Tonneijck, L, Ouwens, D M, Kramer, M H H, van Raalte, D H & Smits, M M 2020, ' Effects of dipeptidyl peptidase-4 inhibitor linagliptin versus sulphonylurea glimepiride on systemic haemodynamics in overweight patients with type 2 diabetes : A secondary analysis of an 8-week, randomized, controlled, double-blind trial ', Diabetes, Obesity and Metabolism, vol. 22, no. 10, pp. 1847-1856 . https://doi.org/10.1111/dom.14107
Diabetes, Obesity and Metabolism, 22(10), 1847-1856. Wiley-Blackwell
Diabetes, Obesity & Metabolism
Diabetes, Obesity and Metabolism, 22(10), 1847-1856. Wiley-Blackwell
Diabetes, Obesity & Metabolism
Aim To determine the glucose‐independent effect of the dipeptidyl peptidase‐4 (DPP‐4) inhibitor linagliptin versus the sulphonylurea glimepiride on systemic haemodynamics in the fasting and postprandial state in patients with type 2 diabetes (T
Autor:
L. Bilet, Gert Schaart, Maria T. E. Hopman, Kenneth Meijer, Madeleen Bosma, Tineke van de Weijer, D. Margriet Ouwens, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Dongyan Zhang, Gerald I. Shulman, Esther Moonen-Kornips, Anne Gemmink, Johanna A. Jörgensen, Esther Phielix, Patrick Schrauwen
Publikováno v:
Diabetologia, 63, 6, pp. 1211-1222
Diabetologia, 63(6), 1211-1222. Springer, Cham
Diabetologia
Diabetologia, 63, 1211-1222
Diabetologia, 63(6), 1211-1222. Springer, Cham
Diabetologia
Diabetologia, 63, 1211-1222
Aims/hypothesis Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common denominators of chronic metabolic disorders, like obesity and type 2 diabetes. Yet, whether