Výsledky vyhledávání - "Margrete R. Hellem"

Akademický článek

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.

Autor: Jan Roger Olsen, Anne Margrete Oyan, Kari Rostad, Margrete R Hellem, Jie Liu, Lisha Li, David R Micklem, Hallvard Haugen, James B Lorens, Varda Rotter, Xi-Song Ke, Biaoyang Lin, Karl-Henning Kalland

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62547 (2013)

The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT. We theref

Externí odkaz: https://doaj.org/article/d7fd1bb4aff245c3a9fcd44b2011fe53

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MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells

Autor: Xisong Ke, Anne Margrete Øyan, Emmet McCormack, Karl-Henning Kalland, Mihaela Popa, Wen-Cheng Li, Kari Rostad, Margrete R. Hellem, Yi Qu

Publikováno v: International Journal of Cancer. 133:544-555

MicroRNAs play critical roles in tumorigenesis and metastasis. Here, we report the dual functions of miR-182 and miR-203 in our previously described prostate cell model. MiR-182 and miR-203 were completely repressed during epithelial to mesenchymal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69ee82e804face8efb90dc22e4e794a5
https://doi.org/10.1002/ijc.28056

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Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes

Autor: Jan Roger Olsen, Margrete R. Hellem, Xisong Ke, Karl-Henning Kalland, Waqas Azeem, Yi Qu, Biaoyang Lin, Kristo Marvyin, Lisha Li, Anne Margrete Øyan, Yaping Hua

Publikováno v: BMC Cancer

Background Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required for survival of benign lum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46796a994f1b5c37135ff595221f5827
https://doi.org/10.1186/s12885-016-2453-4

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An androgen response element driven reporter assay for the detection of androgen receptor activity in prostate cells

Autor: Jan Roger Olsen, Kristo Marvyin, Xisong Ke, Margrete R. Hellem, Karl-Henning Kalland, Anne Margrete Øyan, Biaoyang Lin, Waqas Azeem, Yaping Hua, Yi Qu

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0177861 (2017)
PLoS ONE

The androgen receptor (AR) transcription factor plays a key role in the development and progression of prostate cancer, as is evident from the efficacy of androgen-deprivation therapy, AR is also the most frequently mutated gene, in castration resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26a7f94845b19a7e7ea3d7cbf0f888d
https://doi.org/10.1371/journal.pone.0177861

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p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model

Autor: Anne Margrete Øyan, Jan Roger Olsen, David Micklem, Margrete R. Hellem, Kari Rostad, Xisong Ke, Hallvard Haugen, James B. Lorens, Biaoyang Lin, Jie Liu, Varda Rotter, Karl-Henning Kalland, Lisha Li

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62547 (2013)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e024fd91c966df04d6c196162ef2657a
http://europepmc.org/articles/PMC3641034?pdf=render

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Abstract 79: An androgen response element-based reporter assay for the detection of androgen receptor activity in prostate cells

Autor: Waqas Azeem, Lisha Li, Karl-Henning Kalland, Kristo Marvyin, Margrete R. Hellem, Yi Qu, Yaping Hua, Biaoyang Lin, Xisong Ke, Jan Roger Olsen, Anne Margrete Øyan

Publikováno v: Cancer Research. 75:79-79

Background: The androgen receptor (AR) transcription factor plays pivotal roles in the development and progression of prostate cancer. AR is activated and maintained throughout prostate cancer progression even in castration-resistant prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edd38d0a6aa6acc07c57c7b5bb064fb0
https://doi.org/10.1158/1538-7445.am2015-79

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Abstract 2329: Restriction of androgen receptor and target gene expression

Autor: Yi Qu, Lisha Li, Varda Rotter, Jan Roger Olsen, Margrete R. Hellem, Anne Margrete Øyan, Kari Rostad, Xisong Ke, Kristo Marvyin, Jie Liu, Yaping Hua, Karl-Henning Kalland, Biaoyang Lin

Publikováno v: Cancer Research. 74:2329-2329

Background: The androgen receptor (AR) is activated and pathogenic in castration resistant prostate cancer (CRPC) due to a variety of escape mechanisms from anti-androgen treatment. The “cell of origin” of prostate cancer is not finally defined,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c380eb109811b014b72bc5037b5f50da
https://doi.org/10.1158/1538-7445.am2014-2329

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Abstract 1820: TP63 regulation of epithelial to mesenchymal transition in an experimental prostate cell model

Autor: Xisong Ke, Jie Liu, Kari Rostad, Jan Roger Olsen, Biaoyang Lin, Varda Rotter, Lisha Li, Karl-Henning Kalland, Anne Margrete Øyan, James B. Lorens, Hallvard Haugen, Margrete R. Hellem, David Micklem

Publikováno v: Cancer Research. 73:1820-1820

Background: p63 is a transcription factor that is central for epithelial homeostasis and development. In our cell culture model of epithelial to mesenchymal transition (EMT) in a human prostate cells, p63 was one of the most down-regulated transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3b9a9bfe08062dcedd42fc7cc1fdee6
https://doi.org/10.1158/1538-7445.am2013-1820

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Abstract 1290: The ability of the transcription factor p63 to induce selected gene expression modules associated with mesenchymal to epithelial transition of prostate cells

Autor: Kari Rostad, Varda Rotter, Xisong Ke, Margrete R. Hellem, Yi Qu, James B. Lorens, David Micklem, Jan Roger Olsen, Ole J. Halvorsen, Biaoyang Lin, Lars A. Akslen, Anne Margrete Øyan, Hallvard Haugen, Karl H. Kalland, Karsten Gravdal

Publikováno v: Cancer Research. 72:1290-1290

Genome-wide gene expression analysis identified p63 as one of the most consistently under-expressed transcription factors in prostate cancer samples compared to matched benign prostate tissue. Two alternative p63 promoters generate two different N-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3072f8c4852327038841c6d27dbd4547
https://doi.org/10.1158/1538-7445.am2012-1290

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Abstract 4128: miR203 induces mesenchymal to epithelial transition via repressing SNAI2 and activating P-cadherin in prostate cells

Autor: Xisong Ke, Jigang Zhang, Anne Margrete Øyan, Yi Qu, Wei-Dong Zhang, Wen-Cheng Li, Run-Hui Liu, Kari Rostad, Karl H. Kalland, Margrete R. Hellem

Publikováno v: Cancer Research. 72:4128-4128

MicroRNAs play critical roles in tumorigenesis and metastasis. Here we report the functions of miR203 in prostate cancer based upon an experimental cell culture model. While highly expressed in prostate epithelial cells, miR203 became completely repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39fec1b20805d1e43df498e9e682e2d9
https://doi.org/10.1158/1538-7445.am2012-4128

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