Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

Autor: Heleen J. Blussé van Oud-Alblas, Margreke J. E. Brill, Mariska Y. M. Peeters, Dick Tibboel, Meindert Danhof, Catherijne A. J. Knibbe

Publikováno v: BMC Anesthesiology, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for propofol in adolescents undergoing idiopathic scoliosis surgery with an intra

Externí odkaz: https://doaj.org/article/2e21509f15884249a1bf9c8f16b20547

Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria

Autor: Antigoni Kotsaki, Anders N. Kristoffersson, Johan W. Mouton, V. Rognås, Roberto Andini, Vered Daitch, Noa Eliakim-Raz, Emanuele Durante-Mangoni, Yehuda Carmeli, George L. Daikos, Lena E. Friberg, Roni Bitterman, Margreke J. E. Brill, Leonard Leibovici, Anna Skiada, Ursula Theuretzbacher, Jonathan Lellouche, Anastasia Antoniadou, Amir Nutman, Mats O. Karlsson, Mical Paul, Y. Dishon-Benattar

Publikováno v: Clinical Microbiology and Infection, 26(12), 1644-1650. Elsevier Ltd.

Objectives: The aim was to analyse the population pharmacokinetics of colistin and to explore the relationship between colistin exposure and time to death. Methods: Patients included in the AIDA randomized controlled trial were treated with colistin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4386392b0a615317b54b4e57f051e2
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429140

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

Autor: Johannes N. van den Anker, Berend de Roos, Saskia N. de Wildt, Huixin Yu, Margreke J. E. Brill, Amin Rostami-Hodjegan, Catherijne A. J. Knibbe, Janneke M. Brussee, Elke H. J. Krekels

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. 7:374-383

To predict first-pass and systemic cytochrome P450 (CYP) 3A-mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aee29557201865b6c3331de6acb53edc
https://doi.org/10.1002/psp4.12295

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach

Autor: Elke H. J. Krekels, Amin Rostami-Hodjegan, Margreke J. E. Brill, Janneke M. Brussee, Catherijne A. J. Knibbe, Jeffrey S. Barrett, Semra Palic, Saskia N. de Wildt, Huixin Yu

Publikováno v: Pharmaceutical Research
Pharmaceutical Research, 35, 182
Pharmaceutical Research, 35, 9, pp.
Pharmaceutical Research, 35,
Brussee, J M, Yu, H, Krekels, E H J, Palić, S, Brill, M J E, Barrett, J S, Rostami-hodjegan, A, De Wildt, S N & Knibbe, C A J 2018, ' Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach ', Pharmaceutical Research, vol. 35, no. 9 . https://doi.org/10.1007/s11095-018-2458-6
Pharmaceutical Research, 35(9):Unsp 182. Springer New York

Purpose Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both intestinal and hepatic CYP3A-mediated metabolism of midazolam in children in order to predict first-pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7358dd1071d5d27aea91e2f6b2c654e8
https://hdl.handle.net/1765/114694

Midazolam Pharmacokinetics in Morbidly Obese Patients Following Semi-Simultaneous Oral and Intravenous Administration: A Comparison with Healthy Volunteers

Autor: Catherijne A. J. Knibbe, Aletta P. I. Houwink, Margreke J. E. Brill, Bert van Ramshorst, Jacobus Burggraaf, René M J Wiezer, Anne van Rongen, Eric P.A. van Dongen

Publikováno v: Clinical Pharmacokinetics

Background While in vitro and animal studies have shown reduced cytochrome P450 (CYP) 3A activity due to obesity, clinical studies in (morbidly) obese patients are scarce. As CYP3A activity may influence both clearance and oral bioavailability in a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9e3f1c6f0e03e542d7bc032b0c3867
https://doi.org/10.1007/s40262-014-0166-x