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pro vyhledávání: '"Margreet CM. Vissers"'
Autor:
Andree G. Pearson, Juliet M. Pullar, John Cook, Emma S. Spencer, Margreet CM. Vissers, Anitra C. Carr, Mark B. Hampton
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101980- (2021)
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition meta
Externí odkaz:
https://doaj.org/article/7b9ed30450164947a618657be3e76d45
Autor:
Christina, Wohlrab, Caroline, Kuiper, Margreet Cm, Vissers, Elisabeth, Phillips, Bridget A, Robinson, Gabi U, Dachs
Publikováno v:
Hypoxia
Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-Hippel-Lind
Publikováno v:
Hypoxia
In solid tumors, HIF1 upregulates the expression of hundreds of genes involved in cell survival, tumor growth, and adaptation to the hypoxic microenvironment. HIF1 stabilization and activity are suppressed by prolyl and asparagine hydroxylases, which