Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Margreet C M Vissers"'
Autor:
Ben Topham, Millie de Vries, Maria Nonis, Rebecca van Berkel, Juliet M. Pullar, Nicholas J. Magon, Margreet C. M. Vissers, Margaret J. Currie, Bridget A. Robinson, David Gibbs, Abel Ang, Gabi U. Dachs
Publikováno v:
Epigenomes, Vol 8, Iss 2, p 17 (2024)
The treatment of metastatic melanoma has been revolutionised by immunotherapy, yet a significant number of patients do not respond, and many experience autoimmune adverse events. Associations have been reported between patient outcome and monocyte su
Externí odkaz:
https://doaj.org/article/f0a8556d4d2b4ffcbb4e8fb7b96cfc9d
Autor:
Rebekah L. I. Crake, Eleanor R. Burgess, George A. R. Wiggins, Nicholas J. Magon, Andrew B. Das, Margreet C. M. Vissers, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, Bridget A. Robinson, Elisabeth Phillips, Gabi U. Dachs
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an intermediate generated in the demethylation of 5-methylcytosine, is present at reduced le
Externí odkaz:
https://doaj.org/article/29bbf00353694620bd5b46e7983ef037
Publikováno v:
Nutrients, Vol 16, Iss 3, p 369 (2024)
Our previous work in guinea pigs revealed that low vitamin C intake during preconception and pregnancy adversely affects fertility, pregnancy outcomes, and foetal and neonatal growth in a sex-dependent manner. To investigate the long-term impact on o
Externí odkaz:
https://doaj.org/article/e4dd4c0f2bd14329998d8640be8c47ad
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1929 (2023)
Ascorbate plays a vital role as a co-factor for a superfamily of enzymes, the 2-oxoglutarate dependent dioxygenases (2-OGDDs), which govern numerous pathways in cancer progression, including the hypoxic response and the epigenetic regulation of gene
Externí odkaz:
https://doaj.org/article/898c43d8ed71463fbf7ae4977234f424
Autor:
Sharna J. Coker, Rebecca M. Dyson, Carlos C. Smith-Díaz, Margreet C. M. Vissers, Mary J. Berry
Publikováno v:
Nutrients, Vol 15, Iss 19, p 4107 (2023)
Identifying how specific nutrients can impact fertility, pregnancy, and neonatal outcomes will yield important insights into the biological mechanisms linking diet and reproductive health. Our study investigates how dietary vitamin C intake affects v
Externí odkaz:
https://doaj.org/article/31e1f5e8e2884e248fde7009674167be
Autor:
Eleanor R. Burgess, Rebekah L. I. Crake, Elisabeth Phillips, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, George A. R. Wiggins, Margreet C. M. Vissers, Bridget A. Robinson, Gabi U. Dachs
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma multiforme is a challenging disease with limited treatment options and poor survival. Glioblastoma tumours are characterised by hypoxia that activates the hypoxia inducible factor (HIF) pathway and controls a myriad of genes that drive c
Externí odkaz:
https://doaj.org/article/f59593b61a444e2e93b8171168297f54
Autor:
Carlos C. Smith-Díaz, Nicholas J. Magon, Judith L. McKenzie, Mark B. Hampton, Margreet C. M. Vissers, Andrew B. Das
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Loss-of-function mutations in the DNA demethylase TET2 are associated with the dysregulation of hematopoietic stem cell differentiation and arise in approximately 10% of de novo acute myeloid leukemia (AML). TET2 mutations coexist with other mutation
Externí odkaz:
https://doaj.org/article/5666ba93b57445d6afc661eecad37b0a
Autor:
Tamlin S. Conner, Benjamin D. Fletcher, Jillian J. Haszard, Juliet M. Pullar, Emma Spencer, Louise A. Mainvil, Margreet C. M. Vissers
Publikováno v:
Nutrients, Vol 14, Iss 19, p 4065 (2022)
We have read the Comment article by Vorland et al. [...]
Externí odkaz:
https://doaj.org/article/ab41a5f62b8e42b398deb97aadd60bd0
Autor:
Tamlin S. Conner, Benjamin D. Fletcher, Jillian J. Haszard, Juliet M. Pullar, Emma Spencer, Louise A. Mainvil, Margreet C. M. Vissers
Publikováno v:
Nutrients, Vol 14, Iss 19, p 4063 (2022)
In the original publication title [...]
Externí odkaz:
https://doaj.org/article/778d8b7834004c2387e8c8f2db055da2
Autor:
Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson, Margreet C. M. Vissers
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathwa
Externí odkaz:
https://doaj.org/article/700ee1aa0e2a4759836ca19c6ee9503b