Severity and progression of structural hand OA is not associated with progression of structural knee OA: The IMI-APPROACH cohort

Autor: Sietse E.S. Terpstra, Lotte A. van de Stadt, Francis Berenbaum, Francisco J. Blanco, Ida K. Haugen, Simon C. Mastbergen, Harrie Weinans, Mylène P. Jansen, Frits R. Rosendaal, Margreet Kloppenburg

Publikováno v: Osteoarthritis and Cartilage Open, Vol 6, Iss 3, Pp 100487- (2024)

Objective: To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA. Methods: We used baseline and two-year follow-up data from the IMI-APP

Externí odkaz: https://doaj.org/article/0e925a2b6d4f48e28354a355f3ce3e28

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Autor: Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li, Melissa N. Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E. Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P. Beilby, Jette Bork-Jensen, Thibaud Boutin, Jennifer A. Brody, Suzanne J. Brown, Ben Brumpton, Purdey J. Campbell, Anne R. Cappola, Graziano Ceresini, Layal Chaker, Daniel I. Chasman, Maria Pina Concas, Rodrigo Coutinho de Almeida, Simone M. Cross, Francesco Cucca, Ian J. Deary, Alisa Devedzic Kjaergaard, Justin B. Echouffo Tcheugui, Christina Ellervik, Johan G. Eriksson, Luigi Ferrucci, Jan Freudenberg, GHS DiscovEHR, Regeneron Genetics Center, Christian Fuchsberger, Christian Gieger, Franco Giulianini, Martin Gögele, Sarah E. Graham, Niels Grarup, Ivana Gunjača, Torben Hansen, Barbara N. Harding, Sarah E. Harris, Stig Haunsø, Caroline Hayward, Jennie Hui, Till Ittermann, J. Wouter Jukema, Eero Kajantie, Jørgen K. Kanters, Line L. Kårhus, Lambertus A. L. M. Kiemeney, Margreet Kloppenburg, Brigitte Kühnel, Jari Lahti, Claudia Langenberg, Bruno Lapauw, Graham Leese, Shuo Li, David C. M. Liewald, Allan Linneberg, Jesus V. T. Lominchar, Jian’an Luan, Nicholas G. Martin, Antonela Matana, Marcel E. Meima, Thomas Meitinger, Ingrid Meulenbelt, Braxton D. Mitchell, Line T. Møllehave, Samia Mora, Silvia Naitza, Matthias Nauck, Romana T. Netea-Maier, Raymond Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, Areti Papadopoulou, Colin N. A. Palmer, Cristian Pattaro, Oluf Pedersen, Annette Peters, Maik Pietzner, Ozren Polašek, Peter P. Pramstaller, Bruce M. Psaty, Ante Punda, Debashree Ray, Paul Redmond, J. Brent Richards, Paul M. Ridker, Tom C. Russ, Kathleen A. Ryan, Morten Salling Olesen, Ulla T. Schultheiss, Elizabeth Selvin, Moneeza K. Siddiqui, Carlo Sidore, P. Eline Slagboom, Thorkild I. A. Sørensen, Enrique Soto-Pedre, Tim D. Spector, Beatrice Spedicati, Sundararajan Srinivasan, John M. Starr, David J. Stott, Toshiko Tanaka, Vesela Torlak, Stella Trompet, Johanna Tuhkanen, André G. Uitterlinden, Erik B. van den Akker, Tibbert van den Eynde, Melanie M. van der Klauw, Diana van Heemst, Charlotte Verroken, W. Edward Visser, Dina Vojinovic, Henry Völzke, Melanie Waldenberger, John P. Walsh, Nicholas J. Wareham, Stefan Weiss, Cristen J. Willer, Scott G. Wilson, Bruce H. R. Wolffenbuttel, Hanneke J. C. M. Wouters, Margaret J. Wright, Qiong Yang, Tatijana Zemunik, Wei Zhou, Gu Zhu, Sebastian Zöllner, Johannes W. A. Smit, Robin P. Peeters, Anna Köttgen, Alexander Teumer, Marco Medici

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range

Externí odkaz: https://doaj.org/article/87582eb11e3e4880b14ffaaf73048c8f

Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study

Autor: Paweł Widera, Paco M.J. Welsing, Samuel O. Danso, Sjaak Peelen, Margreet Kloppenburg, Marieke Loef, Anne C. Marijnissen, Eefje M. van Helvoort, Francisco J. Blanco, Joana Magalhães, Francis Berenbaum, Ida K. Haugen, Anne-Christine Bay-Jensen, Ali Mobasheri, Christoph Ladel, John Loughlin, Floris P.J.G. Lafeber, Agnès Lalande, Jonathan Larkin, Harrie Weinans, Jaume Bacardit

Publikováno v: Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100406- (2023)

Objectives: To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine learning results in patient selection enri

Externí odkaz: https://doaj.org/article/55e22c14dfcd491ebe747a57d5aa24d7

Comparative effectiveness of pharmacological interventions for hand osteoarthritis: a systematic review and network meta-analysis of randomised trials

Autor: Margreet Kloppenburg, Ida K Haugen, Féline PB Kroon, Robin Christensen, Marius Henriksen, Henning Bliddal, Lisa Stamp, Mikael Boesen, Sabrina Mai Nielsen, Simon Tarp, Soren Berg, Anna Dossing, Roy D Altman, Ida Maria Balsby

Publikováno v: RMD Open, Vol 9, Iss 3 (2023)

Objective To explore the comparative effectiveness of pharmacological interventions for hand osteoarthritis (OA).Methods We systematically searched Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials from inception until 26 Decemb

Externí odkaz: https://doaj.org/article/a29ef9adf51d48dfa9c46b03675560bb

Improvement of Pain Symptoms in Musculoskeletal Diseases After Multimodal Spa Therapy in the Austrian Gastein Valley—A Study Based on Longitudinal Registry Data

Autor: Antje van der Zee-Neuen, Julia Fuchs, Sonja Wildburger, Martin Gaisberger, Margreet Kloppenburg, Antonella Fioravanti, Tanja Stamm, Martin Offenbaecher, Rudolf Radlmueller, Wolfgang Foisner, Bertram Hoelzl, Markus Ritter

Publikováno v: International Journal of Public Health, Vol 68 (2023)

Objective: The study aim was to investigate the course of pain in rest and motion in seven different rheumatic diseases (RMD), prior and after multimodal spa therapy including low-dose radon treatment and at 3-, 6-; and 9-month follow up.Methods: Com

Externí odkaz: https://doaj.org/article/b2fca1eefb2a45ab85ed0ab366c00a1e