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pro vyhledávání: '"Margot Treidlinger"'
Autor:
Yumin Bi, Kathryn R. Barber, Sabrina M. Wang, Gary S. Shaw, Patrick O'Donoghue, Margot Treidlinger, Susanna George
Publikováno v:
Biochimica et biophysica acta. General subjects. 1861(11 Pt)
Malfunction of the ubiquitin (Ub) E3 ligase, parkin, leads to defects in mitophagy and protein quality control linked to Parkinson's disease. Parkin activity is stimulated by phosphorylation of Ub at Ser65 (pUbS65). Since the upstream kinase is only