Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Margot N, Wenzel"'
Autor:
Ben Woods, Margot N. Wenzel, Thomas Williams, Sophie R. Thomas, Robert L. Jenkins, Angela Casini
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Within the framework of designing new self-assembled metallosupramolecular architectures for drug delivery, seven [Pd2L4]4+ metallacages (L = 2,6-bis(pyridine-3-ylethynyl)pyridine) featuring different groups in exo-position, selected to enhance the c
Externí odkaz:
https://doaj.org/article/2f9e79f31f864df89104dd10b0d743f0
Publikováno v:
e-Polymers, Vol 20, Iss 1, Pp 369-381 (2020)
The current measurement techniques described in the literature for the determination of the carbonyl index (CI) for polyolefins such as polyethylene and polypropylene were compared and contrasted. These were all found to be inconsistent or inaccurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f6ed1f0bc05aed65af31288bffcf9
https://doi.org/10.1515/epoly-2020-0041
https://doi.org/10.1515/epoly-2020-0041
Autor:
Brech Aikman, Margot N. Wenzel, Andreia F. Mósca, Andreia de Almeida, Wim T. Klooster, Simon J. Coles, Graça Soveral, Angela Casini
Publikováno v:
Inorganics, Vol 6, Iss 4, p 123 (2018)
Gold compounds have been proven to be novel and versatile tools for biological applications, including as anticancer agents. Recently, we explored the potential of Au(III) complexes with bi-dentate N-donor ligands as inhibitors of the membrane water
Externí odkaz:
https://doaj.org/article/dae2d901c8824ceb8dc93b3126bb3b00
Autor:
Mathieu Varache, Olav Andreas Aarstad, Thomas L. Williams, Lydia C. Powell, Elaine Lesley Ferguson, Margot N. Wenzel, David Thomas
Publikováno v:
Molecular Pharmaceutics
Polymer masked–unmasked protein therapy (PUMPT) uses conjugation of a biodegradable polymer, such as dextrin, hyaluronic acid, or poly(l-glutamic acid), to mask a protein or peptide’s activity; subsequent locally triggered degradation of the poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9d486332b5774e03264f89db22f6cc
https://doi.org/10.1021/acs.molpharmaceut.9b00393
https://doi.org/10.1021/acs.molpharmaceut.9b00393
Autor:
Nazzareno Re, Andreia F. Mósca, Valentina Graziani, Graça Soveral, James Alexis Platts, Angela Casini, Alessandro Marrone, Andreia de Almeida, Sophie R. Thomas, Brech Aikman, Cecilia Coletti, Margot N. Wenzel
Publikováno v:
Inorganic Chemistry. 58:2140-2148
A series of six new Au(III) coordination compounds with phenanthroline ligands have been synthesized and studied for the inhibition of the water and glycerol channel aquaporin-3 (AQP3). From a combination of different experimental and computational a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1837eae2fefafd03704f5d92d9db383d
https://doi.org/10.1021/acs.inorgchem.8b03233
https://doi.org/10.1021/acs.inorgchem.8b03233
Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin
Autor:
Jiaying Han, Michael Weinmüller, Brech Aikman, Andreas F B Räder, Florian Reichart, Horst Kessler, Rainer Bischoff, Margot N. Wenzel, Angela Casini, Beatrice S Ludwig, Ben Woods, Peter Horvatovich, Hjalmar P. Permentier, Geny M. M. Groothuis, Stefan Stürup
Publikováno v:
BIOCONJUGATE CHEMISTRY, 29(11), 3856-3865. AMER CHEMICAL SOC
Cisplatin occupies a crucial role in the treatment of various malignant tumours. However, its efficacy and applicability are heavily restricted by severe systemic toxicities and drug resistance. Our study exploits the active targeting of supramolecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6433cb82bbe8a15738500fd7aa8658
https://doi.org/10.1021/acs.bioconjchem.8b00682
https://doi.org/10.1021/acs.bioconjchem.8b00682
Publikováno v:
Inorganic Chemistry. 56:14715-14729
In the supramolecular chemistry field, coordination-driven self-assembly has provided the basis for tremendous growth across many subdisciplines, spanning from fundamental investigations regarding the design and synthesis of new architectures to defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489e302e063f998fe1c5109f89a77d3e
https://doi.org/10.1021/acs.inorgchem.7b02599
https://doi.org/10.1021/acs.inorgchem.7b02599
Autor:
Giampaolo Barone, Andreia de Almeida, Darren Wragg, Stefano Leoni, Graça Soveral, Andreia F. Mósca, Paul Kavanagh, Margot N. Wenzel, Angela Casini
Publikováno v:
De Almeida, A, Mósca, A F, Wragg, D, Wenzel, M, Kavanagh, P, Barone, G, Leoni, S, Soveral, G & Casini, A 2017, ' The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods ', Chemical Communications, vol. 53, no. 27, pp. 3830-3833 . https://doi.org/10.1039/c7cc00318h
The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f558740716d0067801b0b7ae5e07814
https://doi.org/10.1039/c7cc00318h
https://doi.org/10.1039/c7cc00318h
Autor:
Andrew J. P. White, Ferran Gonzàlez de Rivera, James D. E. T. Wilton-Ely, Oriol Rossell, Jonathan A. Robson, Khairil A. Jantan, Margot N. Wenzel
Publikováno v:
Inorganic Chemistry. 55:12982-12996
The disulfide ligand (SC6H4CO2H-4)2 acts as a simple but versatile linker for a range of group 8 transition metals through reaction of the oxygen donors. This leads to a range of homobimetallic ruthenium and osmium alkenyl compounds, [{M(CH═CHR)(CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1bc95dd6e46c35d368b6b46a73c93a
https://doi.org/10.1021/acs.inorgchem.6b02409
https://doi.org/10.1021/acs.inorgchem.6b02409
Autor:
Ben Woods, Edward J. Sayers, Fritz E. Kühn, Brech Aikman, Angela Casini, Daniel Döllerer, Arwyn Tomos Jones, Margot N. Wenzel
Recently, 3-dimensional supramolecular coordination complexes of the metallacage type have been shown to hold promise as drug delivery systems for different cytotoxic agents, including the anticancer drug cisplatin. However, so far only limited infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c8fd3e99d6d8202c212777a85ca67b
https://orca.cardiff.ac.uk/id/eprint/124414/1/JIB-Pd2L4-Bodipy-revised_2019_06_24_final-2.pdf
https://orca.cardiff.ac.uk/id/eprint/124414/1/JIB-Pd2L4-Bodipy-revised_2019_06_24_final-2.pdf
