Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Margot Mezger"'
Publikováno v:
Carcinogenesis. 11(3)
Three major types of cell lines were distinguished according to their capacity for glutathione (GSH) conjugation of extracellularly generated benzo[alpha]pyrene (BaP) metabolites, and the level of DNA binding of such metabolites. (i) Cells, e.g. HepG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ff7e15cce40389335d3b6f2ef6ac0f
https://pubmed.ncbi.nlm.nih.gov/2311192
https://pubmed.ncbi.nlm.nih.gov/2311192
Publikováno v:
Carcinogenesis. 5:975-978
O6-Methylguanine-DNA methyltransferase activity, i.e., the capacity of cells to transfer the methyl group from O6-methylguanine in DNA to protein, was determined in 10 hepatoma cell lines, all derived from Reuber H35 hepatoma but differing in their s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82e155dd96423b4f299820a7e582212
https://doi.org/10.1093/carcin/5.7.975
https://doi.org/10.1093/carcin/5.7.975
Publikováno v:
Carcinogenesis. 8:1051-1058
The study was aimed at determining the role of glutathione (GSH) conjugation in the binding of reactive benzo[a]pyrene (BaP) species to DNA of C3H/10T1/2 cells. In order to suppress GSH conjugation cells were depleted of GSH by treatment with buthion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa08c2b27f897e764a57d58fad7d04f1
https://doi.org/10.1093/carcin/8.8.1051
https://doi.org/10.1093/carcin/8.8.1051
Publikováno v:
Toxicology. 17(2)
Isolated hepatocytes metabolize naphthalene to water soluble compounds. During metabolism, reactive intermediates are formed which bind irreversibly to cellular macromolecules. When naphthalene concentrations in the incubation were raised from 400 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab278a8556ec1023a072ed8fe49966a
https://pubmed.ncbi.nlm.nih.gov/7209993
https://pubmed.ncbi.nlm.nih.gov/7209993
Publikováno v:
Chemico-biological interactions. 20(3)
The irreversible binding of [14C] 2,2'-di- and [14C] 2,4,5,2',4',5'-hexachlorobiphenyl ([14C] DCB and [14C] HCB) to protein was studied in the presence of rat liver microsomes and a NADPH-generating system. Protein-bound radioactivity was found with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b41aaf39262ad59e8aa64201681d4b
https://pubmed.ncbi.nlm.nih.gov/418886
https://pubmed.ncbi.nlm.nih.gov/418886
Publikováno v:
Biological Reactive Intermediates—II ISBN: 9781475706765
Naphthalene is metabolized in the liver to its epoxide which either may be converted enzymatically to the glutathione conjugate or to the naphthalene dihydrodiol leading to quinones, or may rearrange non-enzymatically to the corresponding phenol (Jer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d620d4b3b329a2d0606e92343d3eb4
https://doi.org/10.1007/978-1-4757-0674-1_55
https://doi.org/10.1007/978-1-4757-0674-1_55
Publikováno v:
Biological Reactive Intermediates—II ISBN: 9781475706765
Among hepatotoxic chemicals, bromobenzene is a well known example of a compound thought to induce liver cell necrosis via metabolic activation to protein-binding reactive species. The primarily formed 3,4-epoxide has been suggested to be the reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3b6e4e1d5db87151d99a11780133fa
https://doi.org/10.1007/978-1-4757-0674-1_27
https://doi.org/10.1007/978-1-4757-0674-1_27