Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Margot Mayer-Pröschel"'
Autor:
Andrew Campbell, Jessica M. Hogestyn, Christopher J. Folts, Brittany Lopez, Christoph Pröschel, David Mock, Margot Mayer-Pröschel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destr
Externí odkaz:
https://doaj.org/article/c31090ca82e3444daa7a868ec7878e14
Autor:
Christopher J Folts, Nicole Scott-Hewitt, Christoph Pröschel, Margot Mayer-Pröschel, Mark Noble
Publikováno v:
PLoS Biology, Vol 14, Iss 12, p e1002583 (2016)
Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunction are poorly understood. We found that toxic lipids relevant to three different LSDs disrupt multiple lysosomal and other ce
Externí odkaz:
https://doaj.org/article/28a39a5d2f5f454699a71f383ae39702
Publikováno v:
ASN Neuro, Vol 7 (2015)
The deleterious effects of anemia on auditory nerve (AN) development have been well investigated; however, we have previously reported that significant functional consequences in the auditory brainstem response (ABR) can also occur as a consequence o
Externí odkaz:
https://doaj.org/article/fd5c2c36e7d74a74baaabe8841d2364d
Identifying a window of vulnerability during fetal development in a maternal iron restriction model.
Autor:
Camelia Mihaila, Jordan Schramm, Frederick G Strathmann, Dawn L Lee, Robert M Gelein, Anne E Luebke, Margot Mayer-Pröschel
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17483 (2011)
It is well acknowledged from observations in humans that iron deficiency during pregnancy can be associated with a number of developmental problems in the newborn and developing child. Due to the obvious limitations of human studies, the stage during
Externí odkaz:
https://doaj.org/article/ef683eb85dd440bdbfa1e0bbacad6d9a
Autor:
Jessica M. Hogestyn, Garrick Salois, Li Xie, Connor Apa, Justin Youngyunpipatkul, Christoph Pröschel, Margot Mayer-Pröschel
Publikováno v:
Mol Cell Neurosci
Many neurodegenerative diseases have a multifactorial etiology and variable course of progression that cannot be explained by current models. Neurotropic viruses have long been suggested to play a role in these diseases, although their exact contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13af111ea3a5e5fd7da51759f0f9a78
https://pubmed.ncbi.nlm.nih.gov/36055520
https://pubmed.ncbi.nlm.nih.gov/36055520
Autor:
Rachel Warren, Andrew M. Dylag, Molly Behan, William Domm, Min Yee, Margot Mayer-Pröschel, Luis Martinez-Sobrido, Michael A. O’Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Children and young adults with mutant forms of ataxia telangiectasia mutated (ATM), a kinase involved in DNA damage signaling and mitochondrial homeostasis, suffer from recurrent respiratory infections, immune deficiencies, and obstructive airways di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cdbea1d72d8a5e4a016cf32a3bfdb4
https://europepmc.org/articles/PMC8993527/
https://europepmc.org/articles/PMC8993527/
Autor:
William Domm, Min Yee, Jane E. Malone, Andrew Campbell, Rachel Warren, Terry W. Wright, Margot Mayer-Pröschel, Michael A. O'Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Ataxia-telangiectasia (A-T), caused by mutations in the A-T mutated ( ATM) gene, is a neurodegenerative disorder affecting ∼1 in 40,000–100,000 children. Recurrent respiratory infections are a common and challenging comorbidity, often leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e758d8fdcc4524cd6ffc91e5987312a
https://doi.org/10.1152/ajplung.00031.2019
https://doi.org/10.1152/ajplung.00031.2019
Autor:
Mark Noble, Christopher J. Folts, Nicole Scott-Hewitt, Gavin Piester, Margot Mayer-Pröschel, Jessica M Hogestyn
Publikováno v:
Human Molecular Genetics. 26:2825-2837
Genome-wide association studies are identifying multiple genetic risk factors for several diseases, but the functional role of these changes remains mostly unknown. Variants in the galactocerebrosidase (GALC) gene, for example, were identified as a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf2e2437bb19b17888c404aa07f02d2
https://doi.org/10.1093/hmg/ddx153
https://doi.org/10.1093/hmg/ddx153
Autor:
Joshua Munger, Mark Noble, Jared Bushman, Andrew Campbell, Christoph Pröschel, Margot Mayer-Pröschel
Publikováno v:
Glia. 64:227-239
Astroglial dysfunction plays an important role in neurodegenerative diseases otherwise attributed to neuronal loss of function. Here we focus on the role of astroglia in ataxia-telangiectasia (A-T), a disease caused by mutations in the ataxia-telangi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5c9735108480e32f8d2dcd9e390169
https://doi.org/10.1002/glia.22925
https://doi.org/10.1002/glia.22925
Autor:
Michael A. Rudy, Margot Mayer-Pröschel
Publikováno v:
ASN NEURO
ASN Neuro, Vol 9 (2017)
ASN Neuro, Vol 9 (2017)
Iron deficiency (ID) affects more than three billion people worldwide making it the most common micronutrient deficiency. ID is most prevalent during gestation and early life, which is of particular concern since its impact on the developing central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfe6debf56cfac47dc420c1482f0a8a
http://europepmc.org/articles/PMC5734468
http://europepmc.org/articles/PMC5734468