SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection

Autor: Szu-Hsien Sam Wu, Heetak Lee, Réka Szép-Bakonyi, Gabriele Colozza, Ayse Boese, Krista R. Gert, Natalia Hallay, Ji-Hyun Lee, Jihoon Kim, Yi Zhu, Margot M. Linssen, Sandra Pilat-Carotta, Peter Hohenstein, Hans-Christian Theussl, Andrea Pauli, Bon-Kyoung Koo

Publikováno v: Experimental and Molecular Medicine, Vol 54, Iss 12, Pp 2188-2199 (2022)

Abstract The generation of conditional alleles using CRISPR technology is still challenging. Here, we introduce a Short Conditional intrON (SCON, 189 bp) that enables the rapid generation of conditional alleles via one-step zygote injection. In this

Externí odkaz: https://doaj.org/article/5d66e37010904229847351b239d105f2

OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

Autor: Tetje C. van der Sluis, Guillaume Beyrend, Esmé T.I. van der Gracht, Tamim Abdelaal, Simon P. Jochems, Robert A. Belderbos, Thomas H. Wesselink, Suzanne van Duikeren, Floortje J. van Haften, Anke Redeker, Laura F. Ouboter, Elham Beyranvand Nejad, Marcel Camps, Kees L.M.C. Franken, Margot M. Linssen, Peter Hohenstein, Noel F.C.C. de Miranda, Hailiang Mei, Adriaan D. Bins, John B.A.G. Haanen, Joachim G. Aerts, Ferry Ossendorp, Ramon Arens

Publikováno v: Cell Reports Medicine, 4(3)
Cell Reports Medicine, 4(3):100939. Cell Press

Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1c543396b38473fc2088a9e12727f8
http://resolver.tudelft.nl/uuid:6acfa17c-62ec-4c22-b97e-ff2805ee5b0d

Involvement of virus-induced interferon production in IgG autoantibody-mediated anemia

Autor: Shozo Izui, Dan Su, Cor Breukel, J. Sjef Verbeek, Jill W. C. Claassens, Mélanie Gaignage, Conny Brouwers, Jean-Paul Coutelier, Margot M. Linssen, Sarah Legrain

Publikováno v: International Journal of Molecular Sciences, 22(16). MDPI
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9027, p 9027 (2021)

Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebe3f03de742beeb5288e00b271c01
https://hdl.handle.net/1887/3213013

FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model

Autor: Thorbald van Hall, Marcel Camps, Cor Breukel, Hreinn Benonisson, Margot M. Linssen, Ferry Ossendorp, Arthur E. H. Bentlage, Conny Brouwers, Gestur Vidarsson, O. J. H. M. Verhagen, Marieke F. Fransen, Remco Visser, Jill W. C. Claassens, J. Sjef Verbeek, Heng Sheng Sow

Publikováno v: International Journal of Cancer. 144:345-354

Immunomodulatory antibodies blocking interactions of coinhibitory receptors to their ligands such as CTLA-4, PD1 and PD-L1 on immune cells have shown impressive therapeutic efficacy in clinical studies. The therapeutic effect of these antibodies is m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52c15f864320028754e3c603001dabc8
https://doi.org/10.1002/ijc.31899

FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines

Autor: Cor Breukel, Heng Sheng Sow, Thorbald van Hall, Margot M. Linssen, Marieke F. Fransen, Ferry Ossendorp, Ramon Arens, Conny Brouwers, Jill W. C. Claassens, Anke Redeker, Hreinn Benonisson, Sjef Verbeek

Publikováno v: Oncotarget

Cytomegalovirus (CMV)-based vaccine vectors are promising vaccine platforms because they induce strong and long-lasting immune responses. Recently it has been shown that vaccination with a mouse CMV (MCMV) vector expressing the melanoma-specific anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7057d33f179c5ac520b99a54c55ddb45
https://doi.org/10.18632/oncotarget.25630