Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Margot J. Mellies"'
Autor:
Peter M. Laskarzewski, John A. Morrison, Kathy K. Kelly, Philip R. Khoury, Margot J. Mellies, Steven J. Samuels, Charles J. Glueck
Publikováno v:
Clinical Genetics. 18:321-328
The purpose of this report was to assess intrafamilial associations of lipids between related and unrelated household members seen in the course of a population-based survey of lipids in schoolchildren and their parents. Fasting plasma total choleste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e18aca68cac0b07ae5a38a45617f7b6
https://doi.org/10.1111/j.1399-0004.1980.tb02292.x
https://doi.org/10.1111/j.1399-0004.1980.tb02292.x
Autor:
Mark E. McGovern, Margot J. Mellies
Publikováno v:
Expert Opinion on Investigational Drugs. 6:31-50
Recent landmark studies using hydroxy-methyl-glutaryl-Co-enzyme A reductase inhibitors (HMG-CoA reductase inhibitors or statins), specifically, pravastatin and simvastatin, have led to dramatic changes in medical practice. These clinical trials have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fef042c5a2e1f3d9781bdeac86a4e3
https://doi.org/10.1517/13543784.6.1.31
https://doi.org/10.1517/13543784.6.1.31
Publikováno v:
Atherosclerosis. 101:97-110
Epidemiologic evidence linking elevated cholesterol concentrations and coronary heart disease (CHD) through the eighth decade of life provides a rationale for lowering cholesterol concentrations to reduce morbidity and mortality from CHD. Pravastatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ba3ba6353837b78d3a3ce389e8b2b
https://doi.org/10.1016/0021-9150(93)90105-4
https://doi.org/10.1016/0021-9150(93)90105-4
Autor:
John B. Kostis, Margot J. Mellies, Henry Y. Pan, Donald B. Hunninghake, Anne C. Goldberg, Helmut G. Schrott, Peter T. Kuo, William Insull
Publikováno v:
Atherosclerosis. 85:219-227
This 8-week multicenter, placebo-controlled trial compared. the efficacy and safety of the HMG-CoA reductase inhibitor, pravastatin, when administered either as single doses of 40 mg in the morning (AM) or evening (PM) or 20 mg twice daily (bid) in 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9acdc21d472f40030fd11eef3a089104
https://doi.org/10.1016/0021-9150(90)90114-x
https://doi.org/10.1016/0021-9150(90)90114-x
Autor:
Donald B. Hunninghake, Ernst J. Schaefer, Robert H. Knopp, Simeon Margolis, W.Virgil Brown, Anne C. Goldberg, Gustav Schonfeld, Margot J. Mellies, Adrian S. Dobs, William Insull, Evan A. Stein
Publikováno v:
Atherosclerosis. 85:81-89
This multicenter, double-blind, placebo-controlled, dose-response study was conducted in patients with primary hypercholesterolemia to examine the effects of pravastatin, a selective inhibitor of HMG-CoA reductase, on plasma lipids and lipoproteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40886322cb401c217660c54848951810
https://doi.org/10.1016/0021-9150(90)90185-l
https://doi.org/10.1016/0021-9150(90)90185-l
Autor:
Eugene Braunwald, Margot J. Mellies, Ronald B. Goldberg, Frank M. Sacks, Lemuel A. Moyé, Barry R. Davis, Barbara V. Howard, Thomas G. Cole, Marc A. Pfeffer, William James Howard
Publikováno v:
Circulation. 98(23)
Background —Although diabetes is a major risk factor for coronary heart disease (CHD), little information is available on the effects of lipid lowering in diabetic patients. We determined whether lipid-lowering treatment with pravastatin prevents r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b315f55c5cc614efee948131b351fbb3
https://pubmed.ncbi.nlm.nih.gov/9843456
https://pubmed.ncbi.nlm.nih.gov/9843456
Publikováno v:
Journal of clinical pharmacology. 33(6)
Lipoprotein a [Lp(a)] has emerged as a critical factor in the assessment of cardiovascular risk. In the study reported here, Lp(a) concentrations were monitored in patients taking pravastatin, a new hydrophilic, HMG-CoA reductase inhibitor. A cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a06cbd686bfaaaab02961ac6e96be39
https://pubmed.ncbi.nlm.nih.gov/8366183
https://pubmed.ncbi.nlm.nih.gov/8366183
Autor:
Frank M. Sacks, Margot J. Mellies, Lemuel A. Moyé, Barbara V. Howard, W.H. Howard, Eugene Braunwald, Ronald B. Goldberg
Publikováno v:
Atherosclerosis. 134:47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e60dbc818e14cf6428dc2070bdd28fd
https://doi.org/10.1016/s0021-9150(97)88324-4
https://doi.org/10.1016/s0021-9150(97)88324-4
Autor:
Peter Laskarzewski, John A. Morrison, Ido deGroot, Kathe A. Kelly, Margot J. Mellies, Philip Khoury, Charles J. Glueck
Publikováno v:
Pediatrics. 64:584-591
This study was designed to assess "tracking" of plasma cholesterol, triglyceride, and high and low density lipoprotein cholesterol (C-HDL, C-LDL), in 108 children followed over a four-year period in the Cincinnati Lipid Research Clinic's Princeton Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f12bcec20c0860839cc14ebdc205036
https://doi.org/10.1542/peds.64.5.584
https://doi.org/10.1542/peds.64.5.584
Publikováno v:
Pediatrics In Review. 2:131-138
PEDIATRIC GENESIS OF ATHEROSCLEROSIS Atherosclerosis results from a variety of pathophysiologic disturbances, some currently recognized, and many undoubtedly not yet recognized, which in aggregate are identified as risk factors. Genetic and environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fbb3337330181cb0aac8c85a39dd9a
https://doi.org/10.1542/pir.2.5.131
https://doi.org/10.1542/pir.2.5.131