Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Margot H.M. Bakker"'
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Akademický článek
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease
Autor: Benjamin Schmid, Bjørn Holst, Christian Clausen, Lamiaa Bahnassawy, Peter Reinhardt, Margot H.M. Bakker, Eva Díaz-Guerra, Carlos Vicario, Pamela V. Martino-Adami, Michaela Thoenes, Alfredo Ramirez, Klaus Flissbach, Clara Grezella, Oliver Brüstle, Michael Peitz, Andreas Ebneth, Alfredo Cabrera-Socorro
Publikováno v: Stem Cell Research, Vol 52, Iss , Pp 102180- (2021)
APOE genotype is the strongest genetic risk factor for Alzheimer’s Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology
Externí odkaz: https://doaj.org/article/ba2956d805ec4ac18265889ef69b2545
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Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease
Autor: Christian Clausen, Alfredo Ramirez, Andreas Ebneth, Pamela V. Martino-Adami, Alfredo Cabrera-Socorro, Eva Díaz-Guerra, Oliver Brüstle, Michaela Thoenes, Benjamin Schmid, Peter Reinhardt, Clara Grezella, Lamiaa Bahnassawy, Carlos Vicario, Bjørn Holst, Margot H.M. Bakker, Michael Peitz, Klaus Fliessbach
Publikováno v: Stem cell research 52, 102180-(2021). doi:10.1016/j.scr.2021.102180
Digital.CSIC. Repositorio Institucional del CSIC
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Stem Cell Research, Vol 52, Iss, Pp 102180-(2021)
APOE genotype is the strongest genetic risk factor for Alzheimer’s Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4181dab3df8fc7815c3f7154867b0c24
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9
Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer's disease
Autor: Mercè Boada, Alfredo Ramirez, Itziar de Rojas, Isabel Hernández, Silvia Gil, Alfredo Cabrera-Socorro, Isabelle Kohler, Agustín Ruiz, Thomas Hankemeier, Cornelia M. van Duijn, Najaf Amin, Margot H.M. Bakker, Lutz Frölich, Adelina Orellana, Lucrezia Hausner, Shahzad Ahmad
Publikováno v: Alzheimer's Research & Therapy
Alzheimers Research & Therapy, 12(1):124. BioMed Central Ltd.
Alzheimer's Research & Therapy, 12(1):124. BioMed Central
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Alzheimer’s Research & Therapy, 12, 124. BMC
Ahmad, S, Orellana, A, Kohler, I, Frölich, L, de Rojas, I, Gil, S, Boada, M, Hernández, I, Hausner, L, Bakker, M H M, Cabrera-Socorro, A, Amin, N, Ramírez, A, Ruiz, A, Hankemeier, T & Van Duijn, C M 2020, ' Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 12, no. 1, 124, pp. 124 . https://doi.org/10.1186/s13195-020-00680-9
Background Lysophosphatidic acids (LPAs) are bioactive signaling phospholipids that have been implicated in Alzheimer’s disease (AD). It is largely unknown whether LPAs are associated with AD pathology and progression from mild cognitive impairment
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94b6d2cf294d00b6ff2192c1b7fa8ed
https://pubmed.ncbi.nlm.nih.gov/33008436
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10
CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers
Autor: Erik Stomrud, Shahzad Ahmad, Nikolaos Giagtzoglou, Anders Mälarstig, Najaf Amin, Ayse Demirkan, Charlotte E. Teunissen, Oskar Hansson, Cornelia M. van Duijn, Wiesje M. van der Flier, Ruiz Agustin, Niklas Mattsson-Carlgren, Thomas Hankemeier, María Eugenia Sáez, Marta del Campo Milan, Alfredo Ramirez, Philip Scheltens, Alfredo Cabrera-Socorro, M. Arfan Ikram, Margot H.M. Bakker
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, 10(1). Nature Publishing Group
Scientific Reports, 10(1):8233. Nature Publishing Group
Scientific reports 10(1), 8233 (2020). doi:10.1038/s41598-020-65038-5
Ahmad, S, Milan, M D C, Hansson, O, Demirkan, A, Agustin, R, Sáez, M E, Giagtzoglou, N, Cabrera-Socorro, A, Bakker, M H M, Ramirez, A, Hankemeier, T, Stomrud, E, Mattsson-Carlgren, N, Scheltens, P, van der Flier, W M, Ikram, M A, Malarstig, A, Teunissen, C E, Amin, N & van Duijn, C M 2020, ' CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers ', Scientific Reports, vol. 10, no. 1, 8233 . https://doi.org/10.1038/s41598-020-65038-5
Scientific Reports, 10, 8233. NATURE PUBLISHING GROUP
Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbe6d970e11e7bf515023a81af181a9
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