Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Margot Grandl"'
Autor:
Stefan Wallner, Evelyn Orsó, Margot Grandl, Tatiana Konovalova, Gerhard Liebisch, Gerd Schmitz
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205706 (2018)
BACKGROUND:Plasmalogens are either phosphatidylcholine (PC P) or phosphatidylethanolamine (PE P) glycerophospholipids containing a vinyl ether moiety in sn-1-position and an esterified fatty acid in sn-2 position. Multiple functions have been propose
Externí odkaz:
https://doaj.org/article/78b1a87f888341b5ae27f9df47c62dc6
Autor:
Stefan Wallner, Margot Grandl, Gerhard Liebisch, Markus Peer, Evelyn Orsó, Alexander Sigrüner, Andrzej Sobota, Gerd Schmitz
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166798 (2016)
Extravasation of macrophages and formation of lipid-laden foam cells are key events in the development and progression of atherosclerosis. The degradation of atherogenic lipoproteins subsequently leads to alterations in cellular lipid metabolism that
Externí odkaz:
https://doaj.org/article/ed9eece0632d49bcbcc658b33b9417f0
Autor:
Stefan Wallner, Margot Grandl, Tatiana Konovalova, Alexander Sigrüner, Thomas Kopf, Markus Peer, Evelyn Orsó, Gerhard Liebisch, Gerd Schmitz
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94102 (2014)
BackgroundDysregulation of monocyte-macrophage differentiation is a hallmark of vascular and metabolic diseases and associated with persistent low grade inflammation. Plasmalogens represent ether lipids that play a role in diabesity and previous data
Externí odkaz:
https://doaj.org/article/c1b5e1c306804366adff0ad44d3bd11c
NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins.
Autor:
Paul Ramm Sander, Markus Peer, Margot Grandl, Ulrich Bogdahn, Gerd Schmitz, Hans Robert Kalbitzer
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56360 (2013)
Oxidized and enzymatically modified low-density lipoproteins (oxLDL and eLDL) play a key role in early stages of atherogenesis. Their uptake by recruited macrophages leads to endolysosomal phospholipidosis or foam cell formation, respectively, each o
Externí odkaz:
https://doaj.org/article/56946c9142a8435790167e03e5a7fc2b
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851:299-306
In the present paper we have performed comparative lipidomic analysis of two prototypic atherogenic LDL modifications, oxidized LDL and enzymatically modified LDL. Oxidization of LDL was carried out with different chemical modifications starting from
Publikováno v:
Chemistry and Physics of Lipids
Chemistry and Physics of Lipids; Vol 164
Chemistry and Physics of Lipids; Vol 164
Recruitment of circulating monocytes and formation of macrophage foam cells in the arterial intima are characteristic features of atherogenesis. Foam cells are formed by cellular uptake and storage of atherogenic lipoproteins, including oxidized LDL
Autor:
Margot Grandl, Gerd Schmitz
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology; Vol 29
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
HDL functions mainly as a cholesterol scavenger, facilitating transport of cholesterol to the liver for conversion to bile acids and secretion into the bile for elimination or recycling in the enterohepatic bile acid cycle. Because of its major funct
Autor:
Gerd Schmitz, Margot Grandl
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids; Vol 1791
This review summarizes the current knowledge of endolysosomal and cytoplasmic lipid storage in macrophages induced by oxidized LDL (Ox-LDL), enzymatically degraded LDL (E-LDL) and other atherogenic lipoprotein modifications, and their relation to the
Autor:
Margot Grandl, Gerd Schmitz
Publikováno v:
Current Opinion in Clinical Nutrition and Metabolic Care
Lipid membrane microdomains are involved in major types of disease, ranging from vascular and metabolic diseases to neurodegeneration, autoimmunity, infectious and inflammatory diseases, and cancer. This review provides an update of membrane microdom
Autor:
Margot Grandl, Gerd Schmitz
Publikováno v:
Antioxidants & Redox Signaling. 9:1499-1518
Hyperlipidemias and small dense LDLs in patients with high-triglyceride low-HDL syndromes lead to a prolonged half life of apoB-containing particles. This is associated with reactive oxygen species (ROS) activation and leads to formation of oxidized