Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Margot Ernst"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/631a3b4840cc46639ea10757fdd24364
Autor:
Veronika Müller, Margot Ernst, Aygul Baykuchkarova, Filip Koniuszewski, Konstantina Bampali, Thomas Seidel, Petra Scholze
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: The plant-based alkaloid muscimol is a potent agonist of inhibitory GABAA-neurotransmitter receptors. GABAA receptors are a heterogeneous family of pentameric complexes, with 5 out of 19 subunits assembling around the central anion pore
Externí odkaz:
https://doaj.org/article/9ad9bcc34438456cab7ff5517ec36bda
Autor:
Filip Koniuszewski, Florian D. Vogel, Irena Dajić, Thomas Seidel, Markus Kunze, Matthäus Willeit, Margot Ernst
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionMedications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics. All benzodiazepines and severa
Externí odkaz:
https://doaj.org/article/6d0385d98de141b7bf745d647ac6b6a5
β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis
Autor:
Aleksandra Garifulina, Theres Friesacher, Marco Stadler, Eva-Maria Zangerl-Plessl, Margot Ernst, Anna Stary-Weinzinger, Anita Willam, Steffen Hering
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue.
Externí odkaz:
https://doaj.org/article/9f38e7c2b0fb44b284dedd98ef6ee721
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Endocannabinoids (eCBS) are endogenously derived lipid signaling molecules that serve as tissue hormones and interact with multiple targets, mostly within the endocannabinoid system (ECS). The ECS is a highly conserved regulatory system involved in h
Externí odkaz:
https://doaj.org/article/403c27d88cd846ad809bd13f38daf2b9
Autor:
Filip Koniuszewski, Florian D. Vogel, Konstantina Bampali, Jure Fabjan, Thomas Seidel, Petra Scholze, Philip B. Schmiedhofer, Thierry Langer, Margot Ernst
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABAARs) and gl
Externí odkaz:
https://doaj.org/article/dc54f068c3bd491a9c80831d692e9b36
Autor:
Martin Krenn, Margot Ernst, Matthias Tomschik, Marco Treven, Matias Wagner, Dominik S. Westphal, Thomas Meitinger, Ekaterina Pataraia, Fritz Zimprich, Susanne Aull‐Watschinger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 11, Pp 2317-2322 (2019)
Abstract Variants in GABRA1 have been associated with different epilepsies ranging from mild generalized forms to epileptic encephalopathies. Despite the broad clinical spectrum, phenotypes were found to be largely concordant within families. Contrar
Externí odkaz:
https://doaj.org/article/645153edc090468e868dad5c72310188
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Pyrazoloquinolinones (PQs) are a versatile class of GABAA receptor ligands. It has been demonstrated that high functional selectivity for certain receptor subtypes can be obtained by specific substitution patterns, but so far, no clear SAR rules emer
Externí odkaz:
https://doaj.org/article/d0ff3f9d34644bb4978a62cdf789f04f
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subt
Externí odkaz:
https://doaj.org/article/f4a17d425d514d119e8d59a445c19640
Autor:
Xenia Simeone, David C. B. Siebert, Konstantina Bampali, Zdravko Varagic, Marco Treven, Sabah Rehman, Jakob Pyszkowski, Raphael Holzinger, Friederike Steudle, Petra Scholze, Marko D. Mihovilovic, Michael Schnürch, Margot Ernst
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different genes, namely α1-6, β1-3, γ1-3, δ, ε, θ, π and ρ1-3. The existence of this wid
Externí odkaz:
https://doaj.org/article/46343707d7194d3e987086a53ab6033f