Výsledky vyhledávání - "Margot C. Miller"

FGFR Inhibition Enhances Sensitivity to Radiation in Non–Small Cell Lung Cancer

Autor: Gopal Iyer, Michael M. Fisher, Gopika SenthilKumar, Margot C. Miller, Randall J. Kimple, Sean Brennan, Kwangok P. Nickel, Samantha T. Bradley, Andrew M. Baschnagel, Justin H. Skiba, Colin Longhurst, Darya Buehler, Saakshi Kaushik

Publikováno v: Mol Cancer Ther

Fibroblast growth factor receptors (FGFR) are commonly altered in non-small cell lung cancer (NSCLC). FGFRs activate multiple pathways including RAS/RAF/MAPK, PI3K/AKT and STAT, which may play a role in the cellular response to radiation. We investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859b6cc9156125d6882cd3148202411c
https://doi.org/10.1158/1535-7163.mct-19-0931

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Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas

Autor: Saakshi Kaushik, Gopika SenthilKumar, Irene M. Ong, Paul M. Harari, Andrew M. Baschnagel, Randall J. Kimple, Gopal Iyer, Rong Hu, Kwangok P. Nickel, Sean Brennan, Lindsey Abel, Steve Goldstein, Michael M. Fisher, Margot C. Miller

Publikováno v: Int J Radiat Oncol Biol Phys

Purpose We examined the capacity of the pan-fibroblast growth factor receptor (FGFR) inhibitor AZD4547 to augment radiation response across a panel of head and neck squamous cell carcinoma (HNSCC) cell lines and xenografts. Methods and Materials FGFR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c178d76d6259213859584ab490617b48
https://pubmed.ncbi.nlm.nih.gov/32298810

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Co-targeting mTORC and EGFR signaling as a therapeutic strategy in HNSCC

Autor: Rong Hu, Adam D. Swick, Michael M. Fisher, Randall J. Kimple, Amal M. Javaid, Kwangok P. Nickel, Prashanth J. Prabakaran, Mari Iida, Deric L. Wheeler, Emmanuel Sampene, Irene M. Ong, Justine Yang Bruce, Margot C. Miller

Head and neck squamous cell carcinomas (HNSCC) are frequently altered along the PI3K/AKT/mTORC signaling axis. Despite excellent preclinical data, the use of compounds targeting this pathway as monotherapy has been underwhelming in initial clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1a5bf18a478f48e0af5c9c3dac743
https://europepmc.org/articles/PMC5505754/

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Abstract 2924: Evaluation of the pan-FGFR inhibitor AZD4547 with radiation in non-small cell lung cancer

Autor: Gopika SenthilKumar, Gopal Iyer, Margot C. Miller, Lindsey Able, Michael M. Fisher, Sean Brennan, Randall J. Kimple, Saakshi Kaushik, Andrew M. Baschnagel

Publikováno v: Cancer Research. 79:2924-2924

Objective: The fibroblast growth factor receptors (FGFR) are commonly altered in non-small cell lung cancer (NSCLC), including high level of amplification of FGFR1 in lung squamous cell carcinoma. FGFR signaling may play a role in the response to rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99c0c6ced69b510ba7f0ccd8234c3cba
https://doi.org/10.1158/1538-7445.am2019-2924

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Abstract 2929: Radiosensitization of head and neck cancer by FGFR inhibition

Autor: Gopika SenthilKumar, Michael M. Fisher, Randall J. Kimple, Lindsey Able, Gopal Iyer, Paul M. Harari, Sean Brennan, Saakshi Kaushik, Margot C. Miller, Andrew M. Baschnagel

Publikováno v: Cancer Research. 79:2929-2929

Objective: Fibroblast growth factor receptors are frequently amplified or overexpressed in head and neck squamous cell carcinomas (HNSCC). We assessed the potential of a selective FGFR-kinase inhibitor, AZD4547, to act as a radiosensitizer in head an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c43140070963a84951996bf141e1def
https://doi.org/10.1158/1538-7445.am2019-2929

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Abstract 51: Potential and challenges in co-targeting mTORC and EGFR signaling as a therapeutic strategy in HNSCC

Autor: Margot C. Miller, Michael M. Fisher, Deric L. Wheeler, Emmanuel Sampene, Adam D. Swick, Irene M. Ong, Justine Yang Bruce, Amal M. Javaid, Randall J. Kimple, Kwangok P. Nickel, Prashanth J. Prabakaran, Mari Iida

Publikováno v: Clinical Cancer Research. 23:51-51

Background: Head and neck squamous cell carcinomas (HNSCCs) have high rates of mutation and other alterations along the PI3K/AKT/mTORC signaling axis. This has led to interest in the use of therapeutics targeting this pathway; however, identifying re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c48c24a4e09b7d544241ccbb03d358
https://doi.org/10.1158/1557-3265.aacrahns17-51

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Abstract 149: Co-targeting mTORC and EGFR signaling as a potential therapeutic strategy in HNSCC

Autor: Irene M. Ong, Margot C. Miller, Michael M. Fisher, Emmanuel Sampene, Randall J. Kimple, Kwangok P. Nickel, Amal M. Javaid, Prashanth J. Prabakaran, Adam D. Swick

Publikováno v: Cancer Research. 77:149-149

Background - Head and neck squamous cell carcinomas (HNSCCs) have high rates of mutation and other alterations along the PI3K/AKT/mTORC signaling axis. This has led to interest in the use of therapeutics targeting this pathway, however identifying re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c844ac39743285de2352bd4a2aec4d43
https://doi.org/10.1158/1538-7445.am2017-149

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