Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Margot, Van der Jeught"'
1
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells
Autor: Filip Van Nieuwerburgh, Annekatrien Boel, Susana M. Chuva de Sousa Lopes, Dieter Deforce, Margot Van der Jeught, Laurentijn Tilleman, Jasin Taelman, Petra De Sutter, Swati Mishra, Mina Popovic, Björn Menten, Evi Duthoo, Björn Heindryckx
Publikováno v: STEM CELLS
Stem Cells (Dayton, Ohio)
Stem Cells, 39(5), 551-563. OXFORD UNIVERSITY PRESS
Protocols for specifying human primordial germ cell‐like cells (hPGCLCs) from human embryonic stem cells (hESCs) remain hindered by differences between hESC lines, their derivation methods, and maintenance culture conditions. This poses significant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd0d34e28914dfd8f37facfd4a5a769
https://hdl.handle.net/1887/3280151
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2
Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human
Autor: Dieter Deforce, Mina Popovic, Petra De Sutter, Margot Van der Jeught, Sander Willems, Maarten Dhaenens, Björn Heindryckx, Hendrik Marks, Jasin Taelman, Laura De Clerck
Publikováno v: SCIENTIFIC REPORTS
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Recent progress has enabled the conversion of primed human embryonic stem cells (hESCs) to the naive state of pluripotency, resembling the well-characterized naive mouse ESCs (mESCs). However, a thorough histone epigenetic characterization of this co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5597696f424d75c856d45ec41e82c250
https://doi.org/10.1038/s41598-019-53681-6
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3
Human blastocyst outgrowths recapitulate primordial germ cell specification events
Autor: Jasin Taelman, Maria Gomes Fernandes, Petra De Sutter, Susana M. Chuva de Sousa Lopes, Monika Bialecka, Björn Heindryckx, Mina Popovic, Margot Van der Jeught
Publikováno v: Molecular Human Reproduction
MOLECULAR HUMAN REPRODUCTION
Our current knowledge of the mechanisms leading to human primordial germ cell (PGC) specification stems solely from differentiation experiments starting from human pluripotent stem cells. However, information regarding the origin of PGCs in vivo rema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5163be998cf434ef919bffc554218dfb
https://hdl.handle.net/1887/120528
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4
WNT Inhibition and Increased FGF Signaling Promotes Derivation of Less Heterogeneous Primed Human Embryonic Stem Cells, Compatible with Differentiation
Autor: Björn Heindryckx, Filip Van Nieuwerburgh, Petra De Sutter, Margot Van der Jeught, Monika Bialecka, Mina Popovic, Björn Menten, Susana M. Chuva de Sousa Lopes, Jasin Taelman, Sharat Warrier, Kuniya Abe, Dieter Deforce, Laurentijn Tilleman
Publikováno v: Stem cells and development. 28(9)
Human embryonic stem cells (hESCs) hold great value for future clinical applications. However, standard culture conditions maintain hESCs in a primed state, which bears heterogeneity in pluripotency and a tendency for spontaneous differentiation. To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a570b73c7592c3e4e2183f374c441238
https://pubmed.ncbi.nlm.nih.gov/30827199
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5
Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background
Autor: Jo Vandesompele, Petra De Sutter, Jitesh Neupane, Matthias S Roost, Jasper Anckaert, Susana M. Chuva de Sousa Lopes, Pieter Mestdagh, Mina Popovic, Björn Menten, Sabitri Ghimire, Björn Heindryckx, Filip Van Nieuwerburgh, Margot Van der Jeught, Dieter Deforce
Publikováno v: Scientific Reports
Scientific Reports, 8
SCIENTIFIC REPORTS
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Mouse embryonic stem cells (mESCs) exist in a naive, primed and ground state of pluripotency. While comparative analyses of these pluripotency states have been reported, the mESCs utilized originated from various genetic backgrounds and were derived
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfc72afaaa950b2ff1a6d3880ac7db9
https://doi.org/10.1038/s41598-018-24051-5
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6
Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes
Autor: Petra De Sutter, Margot Van der Jeught, Winnok H. De Vos, Etienne Van den Abbeel, Dimitra Nikiforaki, Mina Popovic, Jitesh Neupane, Yuechao Lu, Sylvie Lierman, Björn Heindryckx, Minerva Ferrer-Buitrago
Publikováno v: Reproductive biomedicine
Patients presenting with abnormally high numbers of immature oocytes at retrieval are more likely to exhibit maturation resistant oocytes. However, the clinical relevance of such events remains unknown. We investigated nuclear maturation competence o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ee9a9b8733d34915cc7479d55528d0
https://hdl.handle.net/10067/1483680151162165141
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8
Stem Cell-Derived Spermatozoa
Autor: Swati Mishra, Margot Van der Jeught, Jasin Taelman, Björn Heindryckx
In vitro derivation of functional gametes from patient-specific pluripotent stem cells would provide new opportunities for genetic parenthood for patients currently facing complete infertility. Not only would it significantly enhance existing treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1694156388ae12ad8c61e977521e29e
https://doi.org/10.1016/b978-0-12-812571-7.00018-6
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9
Inhibition of Transforming Growth Factor β Signaling Promotes Epiblast Formation in Mouse Embryos
Autor: Margot Van der Jeught, Thomas O'Leary, Petra De Sutter, Winnok H. De Vos, Tom Deroo, Jitesh Neupane, Sylvie Lierman, Susana M. Chuva de Sousa Lopes, Sabitri Ghimire, Björn Heindryckx
Publikováno v: Stem cells and development
Stem Cells and Development, 24(4), 497-506
Early lineage segregation in preimplantation embryos and maintenance of pluripotency in embryonic stem cells (ESCs) are both regulated by specific signaling pathways. Small molecules have been shown to modulate these signaling pathways. We examined t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e91db4bd2cc50424d0ab107da9517a3
https://doi.org/10.1089/scd.2014.0206
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10
CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells
Autor: Lies Vantomme, Eva D’haene, Margot Van der Jeught, Sarah Vergult, Eva Van Lombergen, Björn Menten, Pieter-Jan Volders, Eva Z. Jacobs, Sharat Warrier, Björn Heindryckx
Publikováno v: Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee3fe1329ad6e44d288a2944e64e854
http://europepmc.org/articles/PMC5709416
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