Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Margo R. Roberts"'
Autor:
Margo R. Roberts, Yiying Zhang, Martin G. Myers, Priya Duggal, Bradley S. Podd, Stephen M. Becker, Streamson C. Chua, Eric R. Houpt, Xiaoti Guo, William A. Petri
Publikováno v:
Mucosal immunology
Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c536a0144b5ae938e228c46713a568a6
https://doi.org/10.1038/mi.2010.76
https://doi.org/10.1038/mi.2010.76
Autor:
Jill Walker-Brown, Margo R. Roberts
Publikováno v:
Shock. 32:541-547
The sympathetic nervous system modulates immune responses via the secretion of catecholamines and subsequent activation of adrenergic receptors (ARs), and systemic catecholamine levels increase markedly in the setting of endotoxemia and sepsis. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91563a26526e92fcc05c59da48383465
https://doi.org/10.1097/shk.0b013e3181a6eda2
https://doi.org/10.1097/shk.0b013e3181a6eda2
Publikováno v:
Journal of Neuroimmunology. 189:75-87
Microglia are the macrophage population residing in the parenchyma of the central nervous system (CNS), and are thought to play critical roles in CNS development, homeostasis and defense against pathogens. Microglia are capable of rapidly responding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13b449f59c693ffcff5f766a1a1a6ca
https://doi.org/10.1016/j.jneuroim.2007.07.004
https://doi.org/10.1016/j.jneuroim.2007.07.004
Publikováno v:
Autonomic Neuroscience. 131:9-20
The thymus is a primary immune organ that is essential for the development of functional T cells. The thymus receives sympathetic innervation, and thymocytes and thymic epithelial cells express functional adrenergic receptors. In this study, we emplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f62e71583834994f4383e76909fbb80
https://doi.org/10.1016/j.autneu.2006.06.001
https://doi.org/10.1016/j.autneu.2006.06.001
Autor:
Margo R. Roberts, Courtney A. Brannan
Publikováno v:
Glia. 48:120-131
Microglia are the immunoregulatory cells of the central nervous system (CNS) and share many characteristics with resident macrophages in extracerebral tissues. Nitric oxide (NO) is secreted by macrophages following induction of the NO synthase gene N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da8c8bb0dad5f2d37ea38f370c49d21
https://doi.org/10.1002/glia.20066
https://doi.org/10.1002/glia.20066
Autor:
Andreas Bakker, Steven G. Deeks, Matthew T. Downs, Kristen Hege, David T. Scadden, Rukmini Pennathur-Das, Ronald T. Mitsuyasu, Margo R. Roberts, Peter A. Anton, Sayeh Jalali, Carl H. June, Andy Lin, Elizabeth Connick
Publikováno v:
Blood. 96:785-793
We have genetically engineered CD4+ and CD8+ T cells with human immunodeficiency virus (HIV) specificity by inserting a gene, CD4ζ, containing the extracellular domain of human CD4 (which binds HIV env) linked to the zeta (ζ) chain of the T-cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106a0bf2dd881624a0059d36eeb7ca85
https://doi.org/10.1182/blood.v96.3.785.015k10_785_793
https://doi.org/10.1182/blood.v96.3.785.015k10_785_793
Autor:
Margo R. Roberts, Keegan S. Cooke, Annie-Chen Tran, Kent A. Smith, Wei Yu Lin, Martin Wang, Thomas J. Dull, Deborah Farson, Krisztina M. Zsebo, Mitchell H. Finer
Publikováno v:
The Journal of Immunology. 161:375-384
TCR- and IgG-binding Fc receptors (FcγR) mediate a variety of critical biologic activities including cytolysis via the structurally related ζ- and γ-chains. In previous studies, we have described chimeric immune receptors (CIR) in which the ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa9287c9bc51bf25d3f051670dffc70
https://doi.org/10.4049/jimmunol.161.1.375
https://doi.org/10.4049/jimmunol.161.1.375
Publikováno v:
The Journal of Experimental Medicine
Gene modification of hematopoietic stem cells (HSC) with antigen-specific, chimeric, or "universal" immune receptors (URs) is a novel but untested form of targeted immunotherapy. A human immunodeficiency virus (HIV) envelope-specific UR consisting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90069ebb69af685856b0ba95058b2f4
https://doi.org/10.1084/jem.184.6.2261
https://doi.org/10.1084/jem.184.6.2261
Autor:
Lu Qin, Mitchell H. Finer, Annie Chen Tran, Jerome E. Groopman, Daniel J. Capon, Thomas Dull, Margo R. Roberts, Dezhen Zhang, Randal A. Byrn, Douglas H. Smith
Publikováno v:
Blood. 84:2878-2889
We have developed an immunotherapeutic approach with potential application in the treatment of viral and malignant disease. We show that primary CD8+ T cells isolated from peripheral blood can be genetically modified by retroviral transduction to exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eafcdfdd7e748817b0460db3f788b2c2
https://doi.org/10.1182/blood.v84.9.2878.2878
https://doi.org/10.1182/blood.v84.9.2878.2878
Autor:
Arianne Perez, Jeff Wiezorek, John M. Rossi, William Y. Go, Margo R. Roberts, David D. Chang, Sean Yoder, Yizhou Jiang, Armen Mardiros, Marika Sherman, James N. Kochenderfer, Lynn Navale, Adrian Bot, Yueh-wei Shen, Steven A. Rosenberg
Publikováno v:
Blood. 126:2042-2042
This study is supported in part by funding from the CooperativeResearch and Development Agreement (CRADA) between the National Cancer Institute and Kite Pharma Introduction: Chimeric antigen receptor (CAR) engineered autologous T-cell therapy has sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a208528d10836664a7f386df381cc6
https://doi.org/10.1182/blood.v126.23.2042.2042
https://doi.org/10.1182/blood.v126.23.2042.2042