Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Margo P. Emont"'
Autor:
Anton Gulko, Adam Essene, Dylan Matthew Belmont-Rausch, Molly Veregge, Deepti Pant, Danielle Tenen, Benedicte Schultz Kapel, Margo P. Emont, Tune H. Pers, Evan D. Rosen, Linus T. Tsai
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102893- (2024)
Summary: Adipocyte size and fragility and commercial kit costs impose significant limitations on single-cell RNA sequencing of adipose tissue. Accordingly, we developed a workflow to isolate and sample-barcode nuclei from individual adipose tissue sa
Externí odkaz:
https://doaj.org/article/a157f48fe49441f8baeda2aeb2d8df32
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109388- (2021)
Summary: Visceral adipose tissue (VAT) depots are associated with the adverse metabolic consequences of obesity, such as insulin resistance. The developmental origin of VAT depots and the identity and regulation of adipocyte progenitor cells have bee
Externí odkaz:
https://doaj.org/article/314695cbd1e7417aa236a5dba6b38d2a
Autor:
Margo P Emont, Evan D Rosen
Publikováno v:
Current Opinion in Genetics & Development. 80:102045
Autor:
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Publikováno v:
Sci Transl Med
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional r
Autor:
Angelica Di Vincenzo, Molly L. Veregge, Samuel J. Lin, Christopher G. Boyd, Adam Essene, Elizabeth McGonagle, Zachary Kramer, Melina Claussnitzer, Anja Jørgensen, Samantha Laber, Tune H. Pers, Margo P. Emont, Antonio Giordano, Eleanna De Filippis, Christopher Jacobs, Aviv Regev, Georgia Colleluori, Deepti Pant, William Gourash, Anton Gulko, Saaket Agrawal, Gregory P. Westcott, Danielle Tenen, Erin Merkel, Anita P. Courcoulas, Linus Tsai, Sophie Strobel, Adam Stefek, Evan D. Rosen, Orr Ashenberg, Hesam Dashti, Harini Srinivasan, Jennifer Ducie, Donald Morris, Bernard T. Lee, Amrita Kar, Amit Khera, Adam M. Tobias
White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b64205c47b354a8b6533c3b86b88af0
https://doi.org/10.1101/2021.11.09.466968
https://doi.org/10.1101/2021.11.09.466968
Autor:
Haopeng Xiao, Luiz H.M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schöder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Publikováno v:
Cell. 185:4654-4673.e28
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over p
Autor:
Margo P. Emont, Evan D. Rosen, Gregory P. Westcott, Linus T.-Y. Tsai, Christopher Jacobs, Jin Li
SummaryVisceral adipose tissue (VAT) depots are associated with the adverse metabolic consequences of obesity, such as insulin resistance. The developmental origin of VAT depots and the identity and regulation of adipocyte progenitor cells have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b607ac82fbbb9ad91eb0df78a15bb6d7
https://doi.org/10.1101/2021.05.13.444022
https://doi.org/10.1101/2021.05.13.444022
Publikováno v:
Endocrinology. 159:2520-2527
It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in bro
Autor:
Ivan Maillard, Xiaona Qiao, Jung Sun Cho, Alexander G. Zestos, Eric Perkey, X.Z. Shawn Xu, Robert T. Kennedy, Dong-Il Kim, Heejin Jun, Hui Yu, Margo P. Emont, Jianke Gong, Juan Jiang, Jianfeng Liu, Jun Wu
Publikováno v:
Nature medicine
Beige adipocytes have recently been shown to regulate energy dissipation when activated and help organisms defend against hypothermia and obesity. Prior reports indicate that beige-like adipocytes exist in adult humans and that they may present novel
Autor:
Sadeesh K. Ramakrishnan, Jun H, Min-Jung Park, Dong-Il Kim, Omary Mb, Liao J, Margo P. Emont, Jun Wu, Jiandie D. Lin, Yatrik M. Shah
Publikováno v:
International journal of obesity (2005)
BACKGROUND/OBJECTIVES Thermogenic fat is present in humans and emerging evidence indicates that increasing the content and activity of these adipocytes may lead to weight loss and improved metabolic health. Multiple reporter systems have been develop