Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Margitta Lebofsky"'
Autor:
Manasi Kotulkar, Diego Paine-Cabrera, Sarah Abernathy, Dakota R. Robarts, Wendena S. Parkes, Kristi Lin- Rahardja, September Numata, Margitta Lebofsky, Hartmut Jaeschke, Udayan Apte
Publikováno v:
Hepatology.
Autor:
Tereza Cristina da Silva, Inar Alves de Castro, Michaël Maes, Isabel Veloso Alves Pereira, Inge Mannaerts, Anwar Farhood, Joost Willebrords, Bruno Cogliati, Hartmut Jaeschke, Maria do Socorro Nogueira, Mathieu Vinken, Valéria Veras Lopes, Jephte Y. Akakpo, Verônica Mollica Govoni, Valery I. Shestopalov, Sara Crespo Yanguas, Margitta Lebofsky, Leo A. van Grunsven
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Pannexins are transmembrane proteins that form communication channels connecting the cytosol of an individual cell with its extracellular environment. A number of studies have documented the presence of pannexin1 in liver as well as its involvement i
Autor:
Zhen Zhang, Natasha E. Zachara, Chad Slawson, Udayan Apte, Ee Phie Tan, Bharat Bhushan, Robert D. Winefield, Sylvie E. Kandel, Steven R. McGreal, Chad Walesky, Margitta Lebofsky, Mitchell R. McGill, Hartmut Jaeschke
Publikováno v:
Toxicological Sciences. 162:599-610
Overdose of acetaminophen (APAP) results in acute liver failure. We have investigated the role of a posttranslational modification of proteins called O-GlcNAcylation, where the O-GlcNAc transferase (OGT) adds and O-GlcNAcase (OGA) removes a single β
Autor:
Sara Crespo Yanguas, Joost Willebrords, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Elke Decrock, Anwar Farhood, Bruno Cogliati, James L. Weemhoff, Luc Leybaert, Michaël Maes, Margitta Lebofsky, Hartmut Jaeschke, Mathieu Vinken
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Historically, connexin hemichannels have been considered as structural precursors of gap junctions. However, accumulating evidence points to independent roles for connexin hemichannels in cellular signaling by connecting the intracellular compartment
Autor:
Margitta Lebofsky, Hartmut Jaeschke, Yuchao Xie, John T. Liles, Anwar Farhood, Anup Ramachandran, David G. Breckenridge
Publikováno v:
Toxicology and Applied Pharmacology. 286:1-9
Metabolic activation and oxidant stress are key events in the pathophysiology of acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by protein adduct formation is amplified by c-jun-N-terminal kinase (JNK), resu
Publikováno v:
Archives of Toxicology. 89:773-783
Chronic Hepatitis C virus (HCV) infection pre-disposes patients to develop liver failure after acetaminophen (APAP) overdose. Mechanisms involved in this were explored using transgenic mice expressing the HCV structural proteins core, E1 and E2. Trea
Autor:
Joost Willebrords, Chloé Abels, Mathieu Vinken, Tereza Cristina da Silva, Silvia Penuela, Jo A. Van Ginderachter, Isabel Veloso Alves Pereira, Anwar Farhood, James L. Weemhoff, Bruno Cogliati, Margitta Lebofsky, Hartmut Jaeschke, Mitchell R. McGill, Michaël Maes, Taynã Tiburcio, Alain Beschin, Sara Crespo Yanguas
Publikováno v:
Archives of toxicology. 91(5)
In the original version, the left picture in the lower panel in Fig. 2b was accidentally duplicated on the right side. The correct picture is the following
Autor:
Udayan Apte, Yuchao Xie, Mitchell R. McGill, Kuo Du, Margitta Lebofsky, Hemantkumar Chavan, Hartmut Jaeschke, Partha Krishnamurthy, Prachi Borude, Bharat Bhushan
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 155(2)
Epidermal growth factor receptor (EGFR) plays a crucial role in hepatocyte proliferation. Its role in acetaminophen (APAP)-mediated hepatotoxicity and subsequent liver regeneration is completely unknown. Role of EGFR after APAP-overdose in mice was s
Autor:
Hartmut Jaeschke, Alain Beschin, Sara Crespo Yanguas, Isabel Veloso Alves Pereira, Anwar Farhood, Margitta Lebofsky, Silvia Penuela, Bruno Cogliati, Chloé Abels, Joost Willebrords, Taynã Tiburcio, James L. Weemhoff, Tereza Cristina da Silva, Mathieu Vinken, Michaël Maes, Mitchell R. McGill, Jo A. Van Ginderachter
Publikováno v:
Anatomy and Cell Biology Publications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
© 2016, Springer-Verlag Berlin Heidelberg. Pannexins constitute a relatively new family of transmembrane proteins that form channels linking the cytoplasmic compartment with the extracellular environment. The presence of pannexin1 in the liver has b
Autor:
Mathieu Vinken, Joost Willebrords, Cintia Maria Monteiro de Araújo, Michaël Maes, Taynã Tiburcio, Tereza Cristina da Silva, Isabel Veloso Alves Pereira, Anwar Farhood, Sara Crespo Yanguas, Maria Lúcia Zaidan Dagli, Mitchell R. McGill, Margitta Lebofsky, Hartmut Jaeschke, Bruno Cogliati
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Connexin32 is the building block of hepatocellular gap junctions, which control direct intercellular communication and thereby act as goalkeepers of liver homeostasis. This study was set up to investigate whether connexin32 is involved in hepatotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4af4f536d080da31ec5e7bef386e9e9