Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate.

Autor: Karen Nieto, Margit Weghofer, Peter Sehr, Mirko Ritter, Sebastian Sedlmeier, Balasubramanyam Karanam, Hanna Seitz, Martin Müller, Markus Kellner, Markus Hörer, Uwe Michaelis, Richard B S Roden, Lutz Gissmann, Jürgen A Kleinschmidt

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39741 (2012)

The human papillomavirus (HPV) minor capsid protein L2 is a promising candidate for a broadly protective HPV vaccine yet the titers obtained in most experimental systems are rather low. Here we examine the potential of empty AAV2 particles (AAVLPs),

Externí odkaz: https://doaj.org/article/c0f00e580da44ff19fa55b03ee7f83e3

The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes

Autor: Margit Weghofer, Kerstin Lux, A. Kuck, Kristin Schmidt, Jürgen A. Kleinschmidt, Karen Nieto, Oliver J. Müller, M. Hörer, Florian Sonntag, Bettina Böttcher, Christina Raupp, K. Köther, B. Gerlach

Publikováno v: Sonntag, F, Koether, K, Schmidt, K, Weghofer, M, Raupp, C, Nieto, K, Kuck, A, Gerlach, B, Boettcher, B, Mueller, O J, Lux, K, Hoerer, M & Kleinschmidt, J A 2011, ' The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes ', Journal of Virology, vol. 85, no. 23, pp. 12686-12697 . https://doi.org/10.1128/JVI.05359-11

Adeno-associated virus type 2 (AAV2) capsid assembly requires the expression of a virally encoded assembly-activating protein (AAP). By providing AAP together with the capsid protein VP3, capsids are formed that are composed of VP3 only. Electron cry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f6df9fdf813a45746a64ee08ca4884
https://doi.org/10.1128/jvi.05359-11

Variability of IgE reactivity profiles among European mite allergic patients

Autor: M. Kronqvist, Wayne R. Thomas, Rudolf Valenta, Margit Weghofer, M. van Hage, Gabrielle Pauli, Susanne Vrtala, Adriano Mari, Hans Grönlund, Ashok Purohit, Friedrich Horak

Publikováno v: European Journal of Clinical Investigation. 38:959-965

Background House dust mites (HDM) Dermatophagoides pteronyssinus are a frequent indoor allergen source. Our aim was to determine the frequencies of IgE reactivity to purified HDM allergen molecules in mite allergic patients from different parts of Eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3dc33ee8b220bca42368bb2ad8bbc2c
https://doi.org/10.1111/j.1365-2362.2008.02048.x

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes

Autor: Sarah A. Brendle, Hatem Zayed, Subhashini Jagu, Karla K. Balogh, Kerstin Pino Tossi, Neil D. Christensen, Joshua W. Wang, Balusubramanyam Karanam, Margit Weghofer, Richard B.S. Roden

Vaccination with the minor capsid protein L2, notably the 17–36 neutralizing epitope, induces broadly protective antibodies, although the neutralizing titers attained in serum are substantially lower than for the licensed L1 VLP vaccines. Here we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5079122384a628b968857fc97d7a5a
https://hdl.handle.net/10576/37339

Different Profiles of Wheat Antigens Are Recognised by Patients Suffering from Coeliac Disease and IgE-Mediated Food Allergy

Autor: Claudia Constantin, Gerhard Granditsch, Margit Weghofer, Wolf Dietrich Huber, Rudolf Valenta

Publikováno v: International Archives of Allergy and Immunology. 138:257-266

Background: Dietary intake of wheat can cause two distinct immunologically mediated diseases with severe gastrointestinal manifestations, coeliac disease (CD) and IgE-mediated food allergy. The pathomechanisms underlying these diseases are different,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420229352c6388ea3d02c74d71cae2db
https://doi.org/10.1159/000088727