Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Margit Kapás"'
Autor:
Antonia Periclou, Susan Willavize, David Jaworowicz, Julie Passarell, Timothy Carrothers, Parviz Ghahramani, Suresh Durgam, Willie Earley, Margit Kapás, Tatiana Khariton
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 362-371 (2020)
Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or b
Externí odkaz:
https://doaj.org/article/723d33f3a14e43b0947d2293e493193c
Autor:
Timothy J. Carrothers, Luann Phillips, Tatiana Khariton, Antonia Periclou, Margit Kapás, Parviz Ghahramani
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Background and Objectives Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist, is approved for the treatment of adults with schizophrenia (1.5–6 mg/day) and manic/mixed (3–6 mg/day) episodes associated with bipolar I disorder. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e591bbf0fcb17832b6e1f4891c9df0
https://doi.org/10.1007/s13318-020-00650-4
https://doi.org/10.1007/s13318-020-00650-4
Autor:
Willie Earley, Julie Passarell, Parviz Ghahramani, Suresh Durgam, Antonia Periclou, Tatiana Khariton, David J. Jaworowicz, Margit Kapás, Susan Willavize, Timothy J. Carrothers
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 362-371 (2020)
Clinical and Translational Science
Clinical and Translational Science
Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure-response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975dfc0263df8d0b876c831e9a392558
https://doaj.org/article/723d33f3a14e43b0947d2293e493193c
https://doaj.org/article/723d33f3a14e43b0947d2293e493193c
Autor:
Yiyun Huang, Nabeel Nabulsi, Deepak Cyril D'Souza, Anissa Abi-Dargham, Margit Kapás, Ragy R. Girgis, Yih Lee, Mark Slifstein, Ashok Rakhit, Bela Kiss, Suresh Durgam, Antonia Periclou, Parviz Ghahramani, Nika Adham, István Laszlovszky, Richard E. Carson
Publikováno v:
Psychopharmacology
Rationale Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9760087b5299300c82783c253f67e1
https://doi.org/10.1007/s00213-016-4382-y
https://doi.org/10.1007/s00213-016-4382-y
Publikováno v:
Clinical Pharmacokinetics. 58:1215-1216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d460fc9f33e488bfe8d9e01175f43e
https://doi.org/10.1007/s40262-019-00795-9
https://doi.org/10.1007/s40262-019-00795-9
Autor:
Tadakatsu Nakamura, Atsushi Iwakaji, Masayoshi Imada, Tomoko Kubota, Yasunori Morio, Margit Kapás
Publikováno v:
Drug Design, Development and Therapy
Tadakatsu Nakamura,1 Tomoko Kubota,1 Atsushi Iwakaji,1 Masayoshi Imada,1 Margit Kapás,2 Yasunori Morio1 1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan; 2Developmental Drug Metabolism and Pharmacokinetics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cb084b8190abff12e9dbf41336688c
https://www.dovepress.com/clinical-pharmacology-study-of-cariprazine-mp-214-in-patients-with-sch-peer-reviewed-article-DDDT
https://www.dovepress.com/clinical-pharmacology-study-of-cariprazine-mp-214-in-patients-with-sch-peer-reviewed-article-DDDT
Autor:
Mária Zájer-Balázs, Károly Tihanyi, Katalin Saghy, Mónika Vastag, Katalin Nogradi, Istvan Vago, Bela Kiss, Margit Kapás, István Greiner, Larisza Gémesi, Zsolt Szombathelyi, György M. Keserű, Éva Ágai-Csongor, Janos Galambos, Eva Schmidt, Istvan Gyertyan, György Domány, Judit Laszy, Aniko Gere, István Laszlovszky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3437-3440
Medicinal chemistry optimization of an impurity isolated during the scale-up synthesis of a pyridylsulfonamide type dopamine D3/D2 compound (1) led to a series of new piperazine derivatives having affinity to both dopamine D3 and D2 receptors. Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1e35c4f2a245e7be871e82a9552b3
https://doi.org/10.1016/j.bmcl.2012.03.104
https://doi.org/10.1016/j.bmcl.2012.03.104
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 48:388-397
Selective and sensitive LC-MS/MS methods have been developed and validated for simultaneous determination of RGH-188, a novel atypical antipsychotic, and its two active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine. Deuter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79a2668cdaaa2cd2154ebcd00884b40
https://doi.org/10.1016/j.jpba.2007.12.016
https://doi.org/10.1016/j.jpba.2007.12.016
Autor:
Eva Csongor, Gabriella Pásztor, Larisza Gémesi, Katalin Saghy, Attila Horváth, Károly Tihanyi, Maria Balazs Nee Dipl Ch Zajer, Bela Kiss, Krisztina Gál, Istvan Gyertyan, Zsolt Szombathelyi, István Laszlovszky, György Domány, Margit Kapás
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:1268-1278
Dopamine D(3) receptor partial agonism has been suggested as a potential therapeutic intervention in cocaine addiction. RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide] was identified as a novel selective dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975937296792ea58a493a0e151cbc7ac
https://doi.org/10.1124/jpet.106.107920
https://doi.org/10.1124/jpet.106.107920
Publikováno v:
Neuropsychopharmacologia Hungarica; sze2019, Vol. 21 Issue 3, p103-118, 16p