Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Margherita Norelli"'
Autor:
Riccardo Biavasco, Emanuele Lettera, Kety Giannetti, Diego Gilioli, Stefano Beretta, Anastasia Conti, Serena Scala, Daniela Cesana, Pierangela Gallina, Margherita Norelli, Luca Basso-Ricci, Attilio Bondanza, Giulio Cavalli, Maurilio Ponzoni, Lorenzo Dagna, Claudio Doglioni, Alessandro Aiuti, Ivan Merelli, Raffaella Di Micco, Eugenio Montini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogen
Externí odkaz:
https://doaj.org/article/fee49380e85c4d6fa86a0b00aa340aa0
Autor:
Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME
Externí odkaz:
https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
Autor:
Monica Casucci, Laura Falcone, Barbara Camisa, Margherita Norelli, Simona Porcellini, Anna Stornaiuolo, Fabio Ciceri, Catia Traversari, Claudio Bordignon, Chiara Bonini, Attilio Bondanza
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Chimeric antigen receptor (CAR)-T cell immunotherapy is at the forefront of innovative cancer therapeutics. However, lack of standardization of cellular products within the same clinical trial and lack of harmonization between different trials have h
Externí odkaz:
https://doaj.org/article/2fbad32be4d1496aa39b24a192390c94
Autor:
Daniela Cesana, Anastasia Conti, Eugenio Montini, Stefano Beretta, Riccardo Biavasco, Claudio Doglioni, Serena Scala, Diego Gilioli, Luca Basso-Ricci, Giulio Cavalli, Pierangela Gallina, Maurilio Ponzoni, Raffaella Di Micco, Alessandro Aiuti, Ivan Merelli, Attilio Bondanza, Margherita Norelli, Kety Giannetti, Emanuele Lettera, Lorenzo Dagna
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activating mutations in the BRAF-MAPK pathway have been reported in histiocytoses, hematological inflammatory neoplasms characterized by multi-organ dissemination of pro-inflammatory myeloid cells. Here, we generate a humanized mouse model of transpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05652830ea4b45f2383d98efb5f8e1bb
Autor:
Margherita Norelli, Renato Ostuni, Giulia Escobar, Barbara Camisa, Attilio Bondanza, Bernhard Gentner, Chiara Brombin, Davide Cittaro, Andrea Annoni, Tiziana Plati, Marco Genua, Luigi Naldini, Luigi Barbarossa, Giulia Barbiera, Anna Ranghetti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Immunotherapy is emerging as a new pillar of cancer treatment with potential to cure. However, many patients still fail to respond to these therapies. Among the underlying factors, an immunosuppressive tumor microenvironment (TME) plays a major role.
Autor:
Monica Casucci, Margherita Norelli, Laura Falcone, Attilio Bondanza, Renato Ostuni, Marco Genua, Maurilio Ponzoni, Chiara Bonini, Barbara Camisa, Francesca Sanvito, Claudio Bordignon, Patrizia Cristofori, Fabio Ciceri, Catia Traversari, Giulia Barbiera, Ayurzana Purevdorj, Claudio Doglioni
Publikováno v:
Nature medicine. 24(6)
In the clinic, chimeric antigen receptor-modified T (CAR T) cell therapy is frequently associated with life-threatening cytokine-release syndrome (CRS) and neurotoxicity. Understanding the nature of these pathologies and developing treatments for the
Autor:
Bernhard Gentner, Fabio Ciceri, Chiara Bonini, Margherita Norelli, Claudio Bordignon, Maurilio Ponzoni, Barbara Camisa, Attilio Bondanza, Laura Falcone, Monica Casucci, Luigi Naldini, Gianpietro Dotti, Fabiana Gullotta, Aurore Saudemont, Benedetta Nicolis di Robilant, Magda Marcatti, Barbara Savoldo, Pietro Genovese, Massimo Bernardi
Publikováno v:
Scopus-Elsevier
Genetically targeted T cells promise to solve the feasibility and efficacy hurdles of adoptive T-cell therapy for cancer. Selecting a target expressed in multiple-tumor types and that is required for tumor growth would widen disease indications and p
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1393
Hematopoietic stem cell transplantation (HSCT) from an allogeneic donor is an effective form of cancer immunotherapy, especially for acute leukemias. HSCT is however frequently complicated by the occurrence of graft-versus-host disease (GVHD). Immuno
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933365
Hematopoietic stem cell transplantation (HSCT) from an allogeneic donor is an effective form of cancer immunotherapy, especially for acute leukemias. HSCT is however frequently complicated by the occurrence of graft-versus-host disease (GVHD). Immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdc34ac26c77bfd934033cd4fa586dc
https://doi.org/10.1007/978-1-4939-3338-9_12
https://doi.org/10.1007/978-1-4939-3338-9_12
Publikováno v:
Biochimica et biophysica acta. 1865(1)
Adoptive cell transfer of T cells genetically modified with tumor-reactive chimeric antigen receptors (CARs) is a rapidly emerging field in oncology, which in preliminary clinical trials has already shown striking antitumor efficacy. Despite these pr