A different perspective for nonphotochemical quenching in plant antenna complexes

Autor: Edoardo Cignoni, Margherita Lapillo, Lorenzo Cupellini, Silvia Acosta-Gutiérrez, Francesco Luigi Gervasio, Benedetta Mennucci

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Nonphotochemical quenching (NPQ) protects photosynthetic complexes from damage due to excess light. Here the authors explore different conformations of the plant CP29 light harvesting complex, showing how protein tuning of carotenoid excitation energ

Externí odkaz: https://doaj.org/article/a0a3b745b91043d68677653ebeecce6f

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

Autor: Laurent R. Chiarelli, Matteo Mori, Giangiacomo Beretta, Arianna Gelain, Elena Pini, Josè Camilla Sammartino, Giovanni Stelitano, Daniela Barlocco, Luca Costantino, Margherita Lapillo, Giulio Poli, Isabella Caligiuri, Flavio Rizzolio, Marco Bellinzoni, Tiziano Tuccinardi, Stefania Villa, Fiorella Meneghetti

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 823-828 (2019)

Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro moiety, leading to the disclosure of a new lead exhibiting a strong activity against MbtI. Ou

Externí odkaz: https://doaj.org/article/6ba177ad0ffa4fc28c89f33af7982d70

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Autor: Giulio Poli, Margherita Lapillo, Carlotta Granchi, Jessica Caciolla, Nayla Mouawad, Isabella Caligiuri, Flavio Rizzolio, Thierry Langer, Filippo Minutolo, Tiziano Tuccinardi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 956-961 (2018)

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s dise

Externí odkaz: https://doaj.org/article/6a3241b07d86496dbf132bf19863cd6e

A New Perspective for Nonphotochemical Quenching in Plant Antenna Complexes

Autor: Francesco Luigi Gervasio, Cignoni E, Benedetta Mennucci, Margherita Lapillo, Acosta Gutierrez S, Lorenzo Cupellini

Light-harvesting complexes (LHCs) of plants exert a dual function of light-harvesting and photoprotection. While LH processes are relatively well characterized, those involved in photoprotection are less understood. The main mechanism involved in pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d7faaaf4274e8e44ce73a7460ca433
https://doi.org/10.26434/chemrxiv.14778270

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Autor: Margherita Lapillo, Jessica Caciolla, Tiziano Tuccinardi, Nayla Mouawad, Flavio Rizzolio, Carlotta Granchi, Giulio Poli, Thierry Langer, Isabella Caligiuri, Filippo Minutolo

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 956-961 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fe70952b9eca358e634079876db218
https://doaj.org/article/6a3241b07d86496dbf132bf19863cd6e