Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Margherita Lapillo"'
Autor:
Edoardo Cignoni, Margherita Lapillo, Lorenzo Cupellini, Silvia Acosta-Gutiérrez, Francesco Luigi Gervasio, Benedetta Mennucci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nonphotochemical quenching (NPQ) protects photosynthetic complexes from damage due to excess light. Here the authors explore different conformations of the plant CP29 light harvesting complex, showing how protein tuning of carotenoid excitation energ
Externí odkaz:
https://doaj.org/article/a0a3b745b91043d68677653ebeecce6f
Autor:
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Publikováno v:
Molecules, Vol 27, Iss 19, p 6535 (2022)
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. In recent years, SIRT1-activating compounds have been demonstrated to exert cardio
Externí odkaz:
https://doaj.org/article/b3bb8f1226714db5a14dbf3ee80039d3
Autor:
Laurent R. Chiarelli, Matteo Mori, Giangiacomo Beretta, Arianna Gelain, Elena Pini, Josè Camilla Sammartino, Giovanni Stelitano, Daniela Barlocco, Luca Costantino, Margherita Lapillo, Giulio Poli, Isabella Caligiuri, Flavio Rizzolio, Marco Bellinzoni, Tiziano Tuccinardi, Stefania Villa, Fiorella Meneghetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 823-828 (2019)
Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro moiety, leading to the disclosure of a new lead exhibiting a strong activity against MbtI. Ou
Externí odkaz:
https://doaj.org/article/6ba177ad0ffa4fc28c89f33af7982d70
Autor:
Giulio Poli, Margherita Lapillo, Vibhu Jha, Nayla Mouawad, Isabella Caligiuri, Marco Macchia, Filippo Minutolo, Flavio Rizzolio, Tiziano Tuccinardi, Carlotta Granchi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 589-596 (2019)
Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of th
Externí odkaz:
https://doaj.org/article/85653fbdcc7c4cae9ce97ddfbaf2d6de
Autor:
Giulio Poli, Margherita Lapillo, Carlotta Granchi, Jessica Caciolla, Nayla Mouawad, Isabella Caligiuri, Flavio Rizzolio, Thierry Langer, Filippo Minutolo, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 956-961 (2018)
Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s dise
Externí odkaz:
https://doaj.org/article/6a3241b07d86496dbf132bf19863cd6e
Autor:
Francesco Luigi Gervasio, Cignoni E, Benedetta Mennucci, Margherita Lapillo, Acosta Gutierrez S, Lorenzo Cupellini
Light-harvesting complexes (LHCs) of plants exert a dual function of light-harvesting and photoprotection. While LH processes are relatively well characterized, those involved in photoprotection are less understood. The main mechanism involved in pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d7faaaf4274e8e44ce73a7460ca433
https://doi.org/10.26434/chemrxiv.14778270
https://doi.org/10.26434/chemrxiv.14778270
Autor:
Carlotta Granchi, Sung Hoon Kim, Tiziano Tuccinardi, Filippo Minutolo, Margherita Lapillo, Kathryn E. Carlson, Massimiliano Giannotti, Flavio Rizzolio, Giulio Poli, Serena Fortunato, Maguie El Boustani, Marco Macchia, Giulia Bononi, Adriano Martinelli, Daniela Nieri, Andrea Chicca, Isabella Caligiuri, John A. Katzenellenbogen
Publikováno v:
European Journal of Medicinal Chemistry. 157:817-836
Monoacylglycerol lipase (MAGL) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid and glycerol. Therefore, MAGL is implicated in many physiological processes involving the regulation of the endocannab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83cd726e910be3c1864ba7acc5dc942
https://doi.org/10.1016/j.ejmech.2018.08.038
https://doi.org/10.1016/j.ejmech.2018.08.038
Autor:
Margherita Lapillo, Jessica Caciolla, Tiziano Tuccinardi, Nayla Mouawad, Flavio Rizzolio, Carlotta Granchi, Giulio Poli, Thierry Langer, Isabella Caligiuri, Filippo Minutolo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 956-961 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fe70952b9eca358e634079876db218
https://doaj.org/article/6a3241b07d86496dbf132bf19863cd6e
https://doaj.org/article/6a3241b07d86496dbf132bf19863cd6e
Autor:
Giulio Poli, Margherita Lapillo, Marco Macchia, Adriano Martinelli, Antonio Giordano, Tiziano Tuccinardi
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 5
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1023 (2019)
Volume 20
Issue 5
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1023 (2019)
The development of target-fishing approaches, aimed at identifying the possible protein targets of a small molecule, represents a hot topic in medicinal chemistry. A successful target-fishing approach would allow for the elucidation of the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278b70cf055ef29b714f600b62314ca0
Autor:
Vibhu Jha, Nayla Mouawad, Flavio Rizzolio, Tiziano Tuccinardi, Margherita Lapillo, Giulio Poli, Marco Macchia, Carlotta Granchi, Isabella Caligiuri, Filippo Minutolo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 589-596 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
Monoacylglycerol lipase (MAGL) is an attractive therapeutic target for many pathologies, including neurodegenerative diseases, cancer as well as chronic pain and inflammatory pathologies. The identification of reversible MAGL inhibitors, devoid of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3858767bab45459f56f2e570c837c6ef
http://hdl.handle.net/11568/961985
http://hdl.handle.net/11568/961985