Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Margherita Di Somma"'
1
Akademický článek
Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
Autor: Margherita Di Somma, Wandert Schaafsma, Elisabetta Grillo, Maria Vliora, Eleni Dakou, Michela Corsini, Cosetta Ravelli, Roberto Ronca, Paraskevi Sakellariou, Jef Vanparijs, Begona Castro, Stefania Mitola
Publikováno v: Cells, Vol 8, Iss 11, p 1457 (2019)
In the treatment of obesity and its related disorders, one of the measures adopted is weight reduction by controlling nutrition and increasing physical activity. A valid alternative to restore the physiological function of the human body could be the
Externí odkaz: https://doaj.org/article/7c23316832c841419049ff5fee1f8f92
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2
Akademický článek
Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance
Autor: Marco Rusnati, Davide Sala, Alessandro Orro, Antonella Bugatti, Gabriele Trombetti, Elena Cichero, Chiara Urbinati, Margherita Di Somma, Enrico Millo, Luis J. V. Galietta, Luciano Milanesi, Paola Fossa, Pasqualina D’Ursi
Publikováno v: Molecules, Vol 23, Iss 1, p 120 (2018)
Cystic fibrosis (CF) is mainly caused by the deletion of Phe 508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome sy
Externí odkaz: https://doaj.org/article/50f5d090a82b44b88d3faf326febd45b
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3
VEGFR2 activation mediates the pro-angiogenic activity of BMP4
Autor: Marco Presta, Elisabetta Grillo, Cosetta Ravelli, Viviane A B Polli, Margherita Di Somma, Daria Leali, Michela Corsini, Stefania Mitola, Sara Rezzola
Publikováno v: Angiogenesis. 22:521-533
The Bone Morphogenetic Protein 4 (BMP4) regulates multiple biological processes, including vascular development and angiogenesis. Here, we investigated the role of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in mediating the angiogenic act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55690591782bc7fb09605ef0bbc55fe
https://doi.org/10.1007/s10456-019-09676-y
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4
A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis
Autor: Cosetta Ravelli, Elisabetta Grillo, Margherita Di Somma, Michela Corsini, Eugenio Monti, Marco Presta, Stefania Mitola, Luca Zammataro
In cancer genomics, recurrence of mutations in gene families that share homologous domains has recently emerged as a reliable indicator of functional impact and can be exploited to reveal the pro-oncogenic effect of previously uncharacterized variant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4069254ee97e6a02fc4ab52a77034c9
http://hdl.handle.net/11379/536921
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5
Speeding up the identification of cystic fibrosis transmembrane conductance regulator-targeted drugs: An approach based on bioinformatics strategies and surface plasmon resonance
Autor: Luis J. V. Galietta, Davide Sala, Pasqualina D'Ursi, Gabriele Trombetti, Luciano Milanesi, Enrico Millo, Elena Cichero, Paola Fossa, Margherita Di Somma, Alessandro Orro, Marco Rusnati, Chiara Urbinati, Antonella Bugatti
Publikováno v: Molecules (Basel, Online) 23 (2018). doi:10.3390/molecules23010120
info:cnr-pdr/source/autori:Rusnati, Marco; Sala, Davide; Orro, Alessandro; Bugatti, Antonella; Trombetti, Gabriele; Cichero, Elena; Urbinati, Chiara; Di Somma, Margherita; Millo, Enrico; Galietta, Luis J. V.; Milanesi, Luciano; Fossa, Paola; D'Ursi, Pasqualina/titolo:Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance./doi:10.3390%2Fmolecules23010120/rivista:Molecules (Basel, Online)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:23
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 1, p 120 (2018)
Molecules; Volume 23; Issue 1; Pages: 120
Cystic fibrosis (CF) is mainly caused by the deletion of Phe 508 (DeltaF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6a3476ff86b1fb2fd3276bcca0392f
http://hdl.handle.net/11588/728896
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6
Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo
Autor: Natascia Campostrini, Michela Asperti, Federica Maccarinelli, Luca Mandelli, Margherita Di Somma, Giuliana Martini, Paola Ruzzenenti, Annamaria Naggi, Domenico Girelli, Maura Poli, Paolo Arosio
Publikováno v: Biochemical Pharmacology. 92:467-475
Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation. Heparins have been shown to be efficient hepcidin inhibitors both in vitro and in vivo, even when their anticoagulant activity has bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391418f2d77641fbd578f13adde14f1c
https://doi.org/10.1016/j.bcp.2014.09.007
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7
High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin
Autor: Paolo Arosio, Maura Poli, Paola Ruzzenenti, Margherita Di Somma, Annamaria Naggi, Michela Asperti, Magdalena Gryzik, Emiliano Esposito
Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 6 (2016)
Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf3fcc5a62f75dc6b9172c737e8edff
https://doi.org/10.3389/fphar.2015.00316
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8
Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
Autor: Eleni Dakou, Roberto Ronca, Stefania Mitola, Michela Corsini, Wandert Schaafsma, Maria Vliora, Paraskevi Sakellariou, Margherita Di Somma, Begoña Castro, Jef Vanparijs, Elisabetta Grillo, Cosetta Ravelli
Publikováno v: Cells
Cells, Vol 8, Iss 11, p 1457 (2019)
Volume 8
Issue 11
In the treatment of obesity and its related disorders, one of the measures adopted is weight reduction by controlling nutrition and increasing physical activity. A valid alternative to restore the physiological function of the human body could be the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff66c1c928616a06d25e271d0a12dbf
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