PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Autor: Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt

Publikováno v: Nature
Rossi, M, Altea-Manzano, P, Demicco, M, Doglioni, G, Bornes, L, Fukano, M, Vandekeere, A, Cuadros, A M, Fernández-García, J, Riera-Domingo, C, Jauset, C, Planque, M, Alkan, H F, Nittner, D, Zuo, D, Broadfield, L A, Parik, S, Pane, A A, Rizzollo, F, Rinaldi, G, Zhang, T, Teoh, S T, Aurora, A B, Karras, P, Vermeire, I, Broekaert, D, Elsen, J V, Knott, M M L, Orth, M F, Demeyer, S, Eelen, G, Dobrolecki, L E, Bassez, A, Brussel, T V, Sotlar, K, Lewis, M T, Bartsch, H, Wuhrer, M, Veelen, P V, Carmeliet, P, Cools, J, Morrison, S J, Marine, J C, Lambrechts, D, Mazzone, M, Hannon, G J, Lunt, S Y, Grünewald, T G P, Park, M, Rheenen, J V & Fendt, S M 2022, ' PHGDH heterogeneity potentiates cancer cell dissemination and metastasis ', Nature, vol. 605, no. 7911, pp. 747-753 . https://doi.org/10.1038/s41586-022-04758-2
Nature, 605(7911), 747-+. NATURE PORTFOLIO

Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e5caca229c7c7298416a476ab4cc79
https://hdl.handle.net/1887/3480405