Monitoring the manufacturing and quality of medicines: a fundamental task of pharmacovigilance

Autor: Marco Sardella, Glyn Belcher, Calin Lungu, Terenzio Ignoni, Manuela Camisa, Doris Irene Stenver, Paolo Porcelli, Margherita D’Antuono, Nicola Gian Castiglione, Anna Adams, Giovanni Furlan, Ilaria Grisoni, Sarah Hall, Laura Boga, Valentina Mancini, Mircea Ciuca, David Chonzi, Brian Edwards, Arduino A Mangoni, Marco Tuccori, Elena Prokofyeva, Fabio De Gregorio, Mario Bertazzoli Grabinski Broglio, Bert van Leeuwen, Paola Kruger, Christian Rausch, Hervé Le Louet

Publikováno v: Therapeutic Advances in Drug Safety, Vol 12 (2021)

The collection and assessment of individual case safety reports (ICSRs) is important to detect unknown adverse drug reactions particularly in the first decade after approval of new chemical entities. However, regulations require that these activities

Externí odkaz: https://doaj.org/article/e2f577c0d23646f1bd9f7bce36bd7551

Two different interictal spike patterns anticipate ictal activity in vitro

Autor: Massimo Avoli, Gabriella Panuccio, Rochelle Herrington, Margherita D'Antuono, Philip de Guzman, Maxime Lévesque

Publikováno v: Neurobiology of Disease, Vol 52, Iss , Pp 168-176 (2013)

4-Aminopyridine (4AP, 50 μM) induces interictal- and ictal-like discharges in brain slices including parahippocampal areas such as the entorhinal cortex (EC) but the relation between these two types of epileptiform activity remains undifined. Here,

Externí odkaz: https://doaj.org/article/a6dde5a5bde1476cbac41832cd8a2ec9

Two different interictal spike patterns anticipate ictal activity in vitro

Autor: Philip de Guzman, Maxime Lévesque, Margherita D'Antuono, Rochelle Herrington, Massimo Avoli, Gabriella Panuccio

Publikováno v: Neurobiology of Disease, Vol 52, Iss, Pp 168-176 (2013)

4-Aminopyridine (4AP, 50 μM) induces interictal- and ictal-like discharges in brain slices including parahippocampal areas such as the entorhinal cortex (EC) but the relation between these two types of epileptiform activity remains undifined. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959601683dda5829ba1ddc564903f9d4
http://www.sciencedirect.com/science/article/pii/S0969996112003877

Diminished Presynaptic GABAB Receptor Function in the Neocortex of a Genetic Model of Absence Epilepsy

Autor: Yugi Inaba, Giuliano Bertazzoni, Margherita D'Antuono, Massimo Avoli, Giuseppe Biagini

Publikováno v: Neurosignals. 17:121-131

Changes in GABAB receptor subunit expression have been recently reported in the neocortex of epileptic WAG/Rij rats that are genetically prone to experience absence seizures. These alterations may lead to hyperexcitability by downregulating the funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e798754540ff222f84885f2208836fd
https://doi.org/10.1159/000197864

Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures

Autor: Margherita D'Antuono, Cristiana Mollinari, Virginia Tancredi, Daniela Merlo, Yuji Inaba, David S. Ragsdale, Anna Maria Rinaldi, Alessio Cardinale, Massimo Avoli, Giovanna D'Arcangelo

Publikováno v: Neurobiology of Disease, Vol 25, Iss 3, Pp 631-641 (2007)
Neurobiology of disease 25 (2007): 631–641.
info:cnr-pdr/source/autori:D. Merlo a,c,1; C. Mollinari a,1; Y. Inaba b; A. Cardinale c; A.M. Rinaldi d; M. D'Antuono d; G. D'Arcangelo d; V. Tancredi d; D. Ragsdale b; M. Avoli b,e 1. Authors equally contributed to the work/titolo:Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures/doi:/rivista:Neurobiology of disease/anno:2007/pagina_da:631/pagina_a:641/intervallo_pagine:631–641/volume:25

Neocortical networks play a major role in the genesis of generalized spike-and-wave (SW) discharges associated with absence seizures in humans and in animal models, including genetically predisposed WAG/Rij rats. Here, we tested the hypothesis that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12e85980d52f5c87d9d0094831b05be
http://www.sciencedirect.com/science/article/pii/S0969996106002993