Mutations in MAPT give rise to aneuploidy in animal models of tauopathy

Autor: Donatella Conconi, Michela Mangieri, Laura Paoletta, Leda Dalprà, Fabrizio Tagliavini, Elena Panzeri, Maria Giulia Ferretti, Giacomina Rossi, Margherita Ruggerone, Elena Piccoli

Publikováno v: Neurogenetics

Tau is a major microtubule-associated protein in brain neurons. Its misfolding and accumulation cause neurodegenerative diseases characterized by brain atrophy and dementia, named tauopathies. Genetic forms are caused by mutations of microtubule-asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0664628697fbef5b0fcb79adf1ea23e4
http://europepmc.org/articles/PMC3968519

MM2-Thalamic Creutzfeldt-Jakob Disease: Neuropathological, Biochemical and Transmission Studies Identify a Distinctive Prion Strain

Autor: Fabrizio Tagliavini, Robert G. Will, Jan P. M. Langeveld, Chiara Vimercati, Fabio Moda, Silvia Suardi, Giuseppe Di Fede, Giorgio Giaccone, Antonio Brambilla, Jean Manson, Ilaria Campagnani, Pietro Zerbi, Margherita Ruggerone, Paolo Fociani, Alessandro Terruzzi, Matthew Bishop, Lucia Limido, Antonio Indaco

Publikováno v: Brain Pathology. 22:662-669

In CreutzfeldtJakob disease (CJD), molecular typing based on the size of the protease resistant core of the disease-associated prion protein (PrPSc) and the M/V polymorphism at codon 129 of the PRNP gene correlates with the clinico-pathologic subtype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27b2b7be15e9b440282292e317eca8ad
https://doi.org/10.1111/j.1750-3639.2012.00572.x

Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein

Autor: Fabio Moda, Nora Hunter, Rona Wilson, Rona Barron, Richard Lockey, Loredana Ingrosso, Margherita Ruggerone, Silvia Suardi, Fabrizio Tagliavini, Olivier Andreoletti, Christopher Plinston, Marco Sbriccoli, Silvia Graziano, Jean Manson, Thierry Baron, Juergen A. Richt, Maurizio Pocchiari, Cristiano Corona, Franco Cardone, Cristina Casalone, Marion Simmons

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2012, 93 (Pt 7), pp.1624-9. ⟨10.1099/vir.0.042507-0⟩
Wilson, R, Plinston, C, Hunter, N, Casalone, C, Corona, C, Tagliavini, F, Suardi, S, Ruggerone, M, Moda, F, Graziano, S, Sbriccoli, M, Cardone, F, Pocchiari, M, Ingrosso, L, Baron, T, Richt, J, Andreoletti, O, Simmons, M, Lockey, R, Manson, J C & Barron, R M 2012, ' Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein ', Journal of General Virology, vol. 93, no. Pt 7, pp. 1624-1629 . https://doi.org/10.1099/vir.0.042507-0

International audience; The association between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) has demonstrated that cattle transmissible spongiform encephalopathies (TSEs) can pose a risk to human health and rais

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c55018a6cc9d2fd3752318a1e6b8e86
https://pubmed.ncbi.nlm.nih.gov/22495232

Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice

Autor: Mauro Giacca, Ilaria Campagnani, Lorena Zentilin, Fabio Moda, Giorgio Giaccone, Fabrizio Tagliavini, Ileana Zucca, Michela Morbin, Chiara Vimercati, Giuseppe Legname, Margherita Ruggerone

Publikováno v: Prion

Prion diseases are caused by a conformational modification of the cellular prion protein (PrP (C)) into disease-specific forms, termed PrP (Sc), that have the ability to interact with PrP (C) promoting its conversion to PrP (Sc). In vitro studies dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac22a24fa455a4aa08e6799c81cdf81
http://hdl.handle.net/20.500.11767/17287

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