Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Margherita, Brindisi"'
Autor:
Giacomo Rossino, Giorgio Marrubini, Margherita Brindisi, Marc Granje, Pasquale Linciano, Daniela Rossi, Simona Collina
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The Heck reaction is widely employed to build a variety of biologically relevant scaffolds and has been successfully implemented in the production of active pharmaceutical ingredients (APIs). Typically, the reaction with terminal alkenes gives high y
Externí odkaz:
https://doaj.org/article/e1a3cedcc161436d905b09c018f6ff44
Autor:
Simona Barone, Baptiste Mateu, Luigia Turco, Sveva Pelliccia, Francesca Lembo, Vincenzo Summa, Elisabetta Buommino, Margherita Brindisi
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Bacterial infections represent a key public health issue due to the occurrence of multidrug-resistant bacteria. Recently, the amount of data supporting the dynamic control of epigenetic pathways by environmental cues has triggered research efforts to
Externí odkaz:
https://doaj.org/article/bb916e0f66d34266ad8bdc3afb5bf635
Autor:
Sveva Pelliccia, Antonella Ilenia Alfano, Beatriz Ramos Gomes Da Assunção, Luigia Turco, Francesca Lembo, Vincenzo Summa, Elisabetta Buommino, Margherita Brindisi
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The [1,2,3]-triazolo [1,5-a] quinoxalin-4(5H)-one scaffold and its analogues triazole-fused heterocyclic compounds are relevant structural templates in both natural and synthetic biologically active compounds. However, their medicinal chemistry appli
Externí odkaz:
https://doaj.org/article/6bf770e98cbd4144a7b6499ba99d96e3
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/9b8a02e6f00e4232b61bad82f9d62f2f
Autor:
Hajar Sirous, Giulia Chemi, Sandra Gemma, Stefania Butini, Zeger Debyser, Frauke Christ, Lotfollah Saghaie, Simone Brogi, Afshin Fassihi, Giuseppe Campiani, Margherita Brindisi
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives as HIV integrase inhibitors (HIV INIs). Starting from a previously developed micromolar inhibitors
Externí odkaz:
https://doaj.org/article/4d460ecf5e42481b9910ecdcf2d5ff1c
Publikováno v:
Journal of Medicinal Chemistry. 65:3080-3097
Compelling new support has been provided for histone deacetylase isoform 6 (HDAC6) as a common thread in the generation of the dysregulated proinflammatory and fibrotic phenotype in cystic fibrosis (CF). HDAC6 also plays a crucial role in bacterial c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7202e2dc0a52611e1e645096118974
https://doi.org/10.1021/acs.jmedchem.1c02067
https://doi.org/10.1021/acs.jmedchem.1c02067
Autor:
Andrea Porcheddu, Rita Mocci, Margherita Brindisi, Federico Cuccu, Claudia Fattuoni, Francesco Delogu, Evelina Colacino, Maria Valeria D'Auria
Publikováno v:
Green Chemistry. 24:4859-4869
We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0001a24579b06054b2950299333d78
https://doi.org/10.1039/d2gc00724j
https://doi.org/10.1039/d2gc00724j
Autor:
Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, CongBao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J. H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A. R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A. C. Gomes, Rita C. Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero
Publikováno v:
Molecules, Vol 25, Iss 13, p 2968 (2020)
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
Externí odkaz:
https://doaj.org/article/d1b45d5624194ce7bc35f0b2a26b0ee6
Autor:
Maria Grazia Ferraro, Antonella Ilenia Alfano, Angela Zampella, Heiko Lange, Elisabetta Buommino, Carlo Irace, Margherita Brindisi
Publikováno v:
ChemMedChem. 16:3795-3809
The generation of peptidomimetic substructures for medicinal chemistry purposes requires effective and divergent synthetic methods. We present in this work an efficient flow process that allows quick modulation of reagents for Joullié-Ugi multicompo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f4b06515d91fdce9be459ad68a320
https://doi.org/10.1002/cmdc.202100474
https://doi.org/10.1002/cmdc.202100474