Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Margery G. Smelkinson"'
Autor:
Nancy Aguilera, Tao Liu, Andrew J. Bower, Joanne Li, Sarah Abouassali, Rongwen Lu, John Giannini, Maximilian Pfau, Chelsea Bender, Margery G. Smelkinson, Amelia Naik, Bin Guan, Owen Schwartz, Andrei Volkov, Alfredo Dubra, Zhuolin Liu, Daniel X. Hammer, Dragan Maric, Robert Fariss, Robert B. Hufnagel, Brett G. Jeffrey, Brian P. Brooks, Wadih M. Zein, Laryssa A. Huryn, Johnny Tam
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
Externí odkaz:
https://doaj.org/article/23f1aa92e6bc467cb2c2e52b88e2d152
Autor:
Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson, Olga Muratova, Nichole D. Salinas, Thiago Luiz Alves e Silva, Karine Reiter, Nicholas J. MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L. Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J. Jenkins, Justin Y. A. Doritchamou, Margery G. Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin J. Taylor, Issaka Sagara, Jonathan P. Renn, Niraj H. Tolia, Patrick E. Duffy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in
Externí odkaz:
https://doaj.org/article/b8a08c9111ab413faed46691e94e1923
Autor:
Camila H. Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D. Galson, Olga Muratova, Nichole D. Salinas, Thiago Luiz Alves e Silva, Karine Reiter, Nicholas J. MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L. Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J. Jenkins, Justin Y. A. Doritchamou, Margery G. Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin J. Taylor, Issaka Sagara, Sara A. Healy, Jonathan P. Renn, Niraj H. Tolia, Patrick E. Duffy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/6d340eb64ddc42069695455873c33002
Autor:
Margery G. Smelkinson
Publikováno v:
Journal of Developmental Biology, Vol 5, Iss 4, p 14 (2017)
The Hedgehog (Hh) signaling pathway plays an essential role in the growth, development, and homeostatis of many tissues in vertebrates and invertebrates. Much of what is known about Hh signaling is in the context of embryonic development and tumor fo
Externí odkaz:
https://doaj.org/article/d3ead4e66f2f4d84a0940bf69a4d4398
Autor:
Margery G Smelkinson, Annabel Guichard, John R Teijaro, Meghana Malur, Maria Eugenia Loureiro, Prashant Jain, Sundar Ganesan, Elina I Zúñiga, Robert M Krug, Michael B Oldstone, Ethan Bier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006588 (2017)
The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epi
Externí odkaz:
https://doaj.org/article/8296206c2f914e29bb8799c937494a0b
Autor:
Erik P. Karmele, Steven E. Bosinger, Jacob K. Flynn, Nihal Altan-Bonnet, Charlotte A. Langner, Luxin Pei, Thomas B. Nutman, Rachele M Bochart, Marianita Santiana, Margery G. Smelkinson, Brian L. Kelsall, Alexandra M. Ortiz, Phillip J. Baker, Edlawit G Gorfu, Jason M. Brenchley
Publikováno v:
Mucosal immunology
Microbial translocation contributes to persistent inflammation in both treated and untreated HIV infection. Although translocation is due in part to a disintegration of the intestinal epithelial barrier, there is a bias towards the translocation of P
Autor:
Karine Reiter, Daniel Veltri, Raul Herrera, Baoshan Zhang, Vu Nguyen, David L. Narum, Sofia Nakuchima, David N. Garboczi, Bruce J. Swihart, Martin Burkhardt, Emily Kelnhofer, Apostolos G. Gittis, Patrick E. Duffy, Olga Muratova, Nicholas J. MacDonald, Richard L. Shimp, Kavita Singh, Margery G. Smelkinson
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here,
Autor:
Yaíma L. Lightfoot, Saeko Nakajima, Verena M. Link, Samira Tamoutounour, Oliver J. Harrison, Christopher K. E. Bleck, Mariana J. Kaplan, E. Merrill, Jonathan L. Linehan, Margery G. Smelkinson, Seong-Ji Han, Yasmine Belkaid, C. Hurabielle, Nicolas Bouladoux, Nickie L Seto, Michail S. Lionakis
Publikováno v:
Proc Natl Acad Sci U S A
Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota
Autor:
Wenyue Dong, Mingfang Lu, Wei Jiang, Yiwei Chu, Chen Yang, Xiaofang Cheng, James Le, Robert S. Munford, Margery G. Smelkinson, Ping Yuan Wang, Paul M. Hwang
Publikováno v:
J Immunol
Although organ hypofunction and immunosuppression are life-threatening features of severe sepsis, the hypofunctioning organs and immune cells usually regain normal functionality if patients survive. Because tissue interstitial fluid can become acidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964f76c9b048e6cdd8d25d076572ec10
https://europepmc.org/articles/PMC8655318/
https://europepmc.org/articles/PMC8655318/
Autor:
Saba Firdous, Harlan D. Caldwell, Li Ma, David W. Dorward, Michael John Patton, Grant McClarty, Margery G. Smelkinson, Chunfu Yang, Lei Lei, Una Karanovic
Publikováno v:
mBio
mBio, Vol 12, Iss 3 (2021)
mBio, Vol 12, Iss 3 (2021)
Chlamydia are obligate intracellular Gram-negative bacteria distinguished by a unique developmental biology confined within a parasitophorous vacuole termed an inclusion. The chlamydial plasmid is a central virulence factor in the pathogenesis of inf