Výsledky vyhledávání - "Margery Chaikin"

Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design

Autor: Carl L. Manthey, Renee L. DesJarlais, Rolanda Reed, Margery Chaikin, Jennifer Lattanze, B. Tomczuk, Juan Jose Marugan, Pierre Raboisson

Publikováno v: European journal of medicinal chemistry. 42(3)

The vitronectin receptor alpha(v)beta(3) has been identified as a promising potential target for the treatment of osteoporosis, diabetic retinopathy and cancer. We have recently reported 5-substituted indoles 3-[5-[2-(5,6,7,8-tetrahydro[1,8]naphthyri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6069a6dca3630ee9b9b78649b448f958
https://pubmed.ncbi.nlm.nih.gov/17184884

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Novel potent and selective alphavbeta3/alphavbeta5 integrin dual antagonists with reduced binding affinity for human serum albumin

Autor: Pierre, Raboisson, Carl L, Manthey, Margery, Chaikin, Jennifer, Lattanze, Carl, Crysler, Kristi, Leonard, Wenxi, Pan, Bruce E, Tomczuk, Juan José, Marugán

Publikováno v: European journal of medicinal chemistry. 41(7)

The binding of lead compounds and drugs to human serum albumin (HSA) is a ubiquitous problem in drug discovery since it modulates the availability of the leads and drugs to their intended target, which is linked to biological efficacy. In our continu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efef2586880cbd30e333f1164fff0b78
https://pubmed.ncbi.nlm.nih.gov/16697080

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Biological characterization and oncogene expression in human colorectal carcinoma cell lines

Autor: Dian‐Jun ‐J Li, Mark Lynch, David Reiman, Deborah L. Trainer, Leo F. Faucette, George Poste, John Feild, Margery Chaikin, Charles Buscarino, Francis L. McCabe, Doris Gennaro, Sylvia T. Hoffstein, Mario A. Anzano, Russell G. Greig, Thomas Kline

Publikováno v: International journal of cancer. 41(2)

To establish well-characterized cellular reagents for the study of colon carcinoma, we have examined 19 human colorectal carcinoma cell lines with regard to morphology, ultrastructure, expression of tumor-associated antigens, proliferative capacity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f40ee14dfbb107a0e436aa8120b6cd
https://pubmed.ncbi.nlm.nih.gov/3338874

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