Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Margery A. Chaikin"'
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c495ed76df00defda047352171a57
https://doi.org/10.1158/1535-7163.c.6531858.v1
https://doi.org/10.1158/1535-7163.c.6531858.v1
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53737462ca7c21b088c7e98afca976
https://doi.org/10.1158/1535-7163.22485255.v1
https://doi.org/10.1158/1535-7163.22485255.v1
Autor:
Christopher J. Molloy, Shelley K. Ballentine, Edward J. Yurkow, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Yanmin Chen, Sanath K. Meegalla, Carl L. Manthey, Mark J. Wall, Bruce E. Tomczuk, Carl R. Illig, Zhao Zhou, Jinsheng Chen, Kenneth J. Wilson, Mark R. Player, Robert R. Donatelli, Margery A. Chaikin
Publikováno v:
Journal of Medicinal Chemistry. 54:7860-7883
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Autor:
Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
Publikováno v:
Molecular Cancer Therapeutics. 8:3151-3161
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Autor:
Yanmin Chen, Christopher J. Molloy, Carl R. Illig, Margery A. Chaikin, Carl L. Manthey, Renee L. DesJarlais, Carl Crysler, Carsten Schubert, Sanath K. Meegalla, Mark R. Player, Jinsheng Chen, Shelley K. Ballentine, Bruce E. Tomczuk, Mark J. Wall, Kenneth J. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3632-3637
An anti-inflammatory 1,2,4-phenylenetriamine-containing series of FMS inhibitors with a potential to form reactive metabolites was transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based
Autor:
Renee L. DesJarlais, Carl R. Illig, Shelley K. Ballentine, Margery A. Chaikin, M. Jonathan Rudolph, Carsten Schubert, Kenneth J. Wilson, Bruce E. Tomczuk, Jinsheng Chen, Mark R. Player, Ioanna Petrounia, Mark J. Wall, Christopher J. Molloy, Yanmin Chen, Sanath K. Meegalla, Carl Crysler, Carl L. Manthey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1642-1648
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthriti
Autor:
Jinsheng Chen, Carl L. Manthey, Kenneth J. Wilson, Marie Mazzulla, Margery A. Chaikin, Christopher J. Molloy, Bruce E. Tomczuk, Edward J. Yurkow, Shelley K. Ballentine, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Ioanna Petrounia, Robert R. Donatelli, Carl R. Illig, Lisa Boczon, Sanath K. Meegalla, Mark J. Wall, Raymond J. Patch, Mark R. Player
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2097-2102
A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-
Autor:
Juan Jose Marugan, Wenxi Pan, Carl Crysler, Carl L. Manthey, Margery A. Chaikin, Bruce E. Tomczuk, Kristi A. Leonard, Jennifer Lattanze, Pierre Raboisson
Publikováno v:
European Journal of Medicinal Chemistry. 41:847-861
The binding of lead compounds and drugs to human serum albumin (HSA) is a ubiquitous problem in drug discovery since it modulates the availability of the leads and drugs to their intended target, which is linked to biological efficacy. In our continu
Autor:
Carl L. Manthey, Juan J. Marugan, Beth M. Anaclerio, Zihong Guo, Kristi A. Leonard, Bruce E. Tomczuk, Peter Baciu, Ming Ni, Jeffrey L. Edelman, Margery A. Chaikin, Stephen Eisennagel, Gerald W. De Vries, Christopher J. Molloy, Wenxi Pan
Publikováno v:
Journal of Biochemical and Biophysical Methods. 65:107-120
Development of alphavbeta3-integrin inhibitors has been hampered by a lack of pharmacodynamic endpoints to identify doses that inhibit alphavbeta3 in vivo. To address this need, we developed an alphavbeta3 radioreceptor assay (RRA) that could be perf
Autor:
Sergei Radaev, Prateeti Khazanie, Anthony S. Fauci, Domenico Mavilio, Peter Schuck, Shyam Kottilil, Claudia Cicala, Donald Van Ryk, James Arthos, Marybeth Daucher, Ronald L. Rabin, Peter D. Sun, Eva Chung, Neil Gupta, Nina Censoplano, Catherine C. Cruz, Tavis D. Steenbeke, Margery A. Chaikin
Publikováno v:
Virology. 332:491-497
Natural killer (NK) cells play an important role in both innate and adaptive antiviral immune responses. The adaptive response typically requires that virus-specific antibodies decorate infected cells which then direct NK cell lysis through a CD16 me