Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Margaux Fresnais"'
Autor:
Margaux Fresnais, Siwen Liang, Deniz Seven, Nevena Prodanovic, Julia Sundheimer, Walter E. Haefeli, Jürgen Burhenne, Rémi Longuespée
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8469 (2023)
The development of desorption/ionization (DI) mass spectrometric (MS) assays for drug quantification in tissue sections and their validation according to regulatory guidelines would enable their universalization for applications in (clinical) pharmac
Externí odkaz:
https://doaj.org/article/6e630e8860b5438ea6131c8e558cd889
Autor:
Margaux Fresnais, Rémi Longuespée, Max Sauter, Torsten Schaller, Michaela Arndt, Jürgen Krauss, Antje Blank, Walter E. Haefeli, Jürgen Burhenne
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24329-24339 (2020)
Externí odkaz:
https://doaj.org/article/e7c9c27da8eb4f9089f3fc091dd9fb20
Autor:
Margaux Fresnais, Siwen Liang, Marius Breitkopf, Joshua Raoul Lindner, Emmanuelle Claude, Steven Pringle, Pavel A. Levkin, Konstantin Demir, Julia Benzel, Julia Sundheimer, Britta Statz, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Jürgen Burhenne, Rémi Longuespée
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 694 (2022)
Desorption/ionization (DI)-mass spectrometric (MS) methods offer considerable advantages of rapidity and low-sample input for the analysis of solid biological matrices such as tissue sections. The concept of desorption electrospray ionization (DESI)
Externí odkaz:
https://doaj.org/article/c72fe06dde8c48938704be0f9dc8de35
Autor:
Margaux Fresnais, Seda Karabulut, Yasmin Abou Zeed, Johannes Ungermann, Julia Benzel, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Jürgen Burhenne, Rémi Longuespée
Publikováno v:
Molecules, Vol 27, Iss 3, p 690 (2022)
Desorption/ionization mass spectrometry (DI-MS) approaches allow for the rapid quantification of drugs in biological matrices using assays that can be validated according to regulatory guidelines. However, specific adaptations must be applied to crea
Externí odkaz:
https://doaj.org/article/892883caa3984bbaba9a823d62fdf1bd
Approaching Sites of Action of Temozolomide for Pharmacological and Clinical Studies in Glioblastoma
Autor:
Margaux Fresnais, Sevin Turcan, Dirk Theile, Johannes Ungermann, Yasmin Abou Zeed, Joshua Raoul Lindner, Marius Breitkopf, Jürgen Burhenne, Walter E. Haefeli, Rémi Longuespée
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 1 (2021)
Temozolomide (TMZ), together with bulk resection and focal radiotherapy, is currently a standard of care for glioblastoma. Absorption, distribution, metabolism, and excretion (ADME) parameters, together with the mode of action of TMZ, make its bioche
Externí odkaz:
https://doaj.org/article/b7b69c001f694632a6dce602e3df5194
Autor:
Margaux Fresnais, Esra Yildirim, Seda Karabulut, Dirk Jäger, Inka Zörnig, Julia Benzel, Kristian W. Pajtler, Stefan M. Pfister, Jürgen Burhenne, Walter E. Haefeli, Rémi Longuespée
Publikováno v:
Molecules, Vol 26, Iss 5, p 1281 (2021)
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has rarely been used in the field of therapeutic drug monitoring, partly because of the complexity of the ionization processes between the compounds to be quantified and the man
Externí odkaz:
https://doaj.org/article/7fc15ac651a140709231ea9225708656
Autor:
Alexandra Russo, Claudia Paret, Francesca Alt, Jürgen Burhenne, Margaux Fresnais, Wolfgang Wagner, Martin Glaser, Hannah Bender, Sabrina Huprich, Patrick N. Harter, Katharina Filipski, Nadine Lehmann, Nora Backes, Lea Roth, Larissa Seidmann, Clemens Sommer, Marc A. Brockmann, Torsten Pietsch, Marie A. Neu, Arthur Wingerter, Jörg Faber
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4267 (2019)
The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood−brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IG
Externí odkaz:
https://doaj.org/article/1e910f23e4c146c898b6d61725250cc8
Autor:
Rémi Longuespée, Dirk Theile, Inka Zörnig, Jessica C. Hassel, Joshua Raoul Lindner, Walter E. Haefeli, Margaux Fresnais
Publikováno v:
International journal of cancerREFERENCES.
Monoclonal antibodies (mAbs) acting as immune checkpoint inhibitors (ICIs) are among the most frequently used immunotherapies in oncology. However, precision medicine approaches to adapt the treatment to the patient are still poorly exploited. Given
Autor:
Walter E. Haefeli, Rémi Longuespée, Dirk Theile, Johanna Weiss, Margaux Fresnais, Jürgen Burhenne
Publikováno v:
British Journal of Clinical Pharmacology. 87:858-874
Clinical pharmacology is an important discipline for drug development aiming to define pharmacokinetics (PK), pharmacodynamics (PD) and optimum exposure to drugs, i.e. the concentration-response relationship and its modulators. For this purpose, info
Autor:
Walter E. Haefeli, Alexander Muck, Ludivine Le Dret, Marius Majewsky, Stefan M. Pfister, Britta Statz, Jürgen Burhenne, Sonja Krausert, David Castel, Julia Benzel, Margaux Fresnais, Rémi Longuespée
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:742-751
Ion mobility spectrometry (IMS) represents a considerable asset for analytics of complex samples as it allows for rapid mass spectrometric separation of compounds. IMS is even more useful for the separation of isobaric compounds when classical separa