Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Margaux F Keller"'
1
Akademický článek
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.
Autor: Irene Pichler, Fabiola Del Greco M, Martin Gögele, Christina M Lill, Lars Bertram, Chuong B Do, Nicholas Eriksson, Tatiana Foroud, Richard H Myers, PD GWAS Consortium, Michael Nalls, Margaux F Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Beben Benyamin, John B Whitfield, Genetics of Iron Status Consortium, Peter P Pramstaller, Andrew A Hicks, John R Thompson, Cosetta Minelli
Publikováno v: PLoS Medicine, Vol 10, Iss 6, p e1001462 (2013)
BackgroundAlthough levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron blood levels on PD risk is inconclusive, with effects reported in opposite direct
Externí odkaz: https://doaj.org/article/1a3b43cf16a34250b3226fdeb1524b3d
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2
Akademický článek
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.
Autor: Clara C Elbers, Yiran Guo, Vinicius Tragante, Erik P A van Iperen, Matthew B Lanktree, Berta Almoguera Castillo, Fang Chen, Lisa R Yanek, Mary K Wojczynski, Yun R Li, Bart Ferwerda, Christie M Ballantyne, Sarah G Buxbaum, Yii-Der Ida Chen, Wei-Min Chen, L Adrienne Cupples, Mary Cushman, Yanan Duan, David Duggan, Michele K Evans, Jyotika K Fernandes, Myriam Fornage, Melissa Garcia, W Timothy Garvey, Nicole Glazer, Felicia Gomez, Tamara B Harris, Indrani Halder, Virginia J Howard, Margaux F Keller, M Ilyas Kamboh, Charles Kooperberg, Stephen B Kritchevsky, Andrea LaCroix, Kiang Liu, Yongmei Liu, Kiran Musunuru, Anne B Newman, N Charlotte Onland-Moret, Jose Ordovas, Inga Peter, Wendy Post, Susan Redline, Steven E Reis, Richa Saxena, Pamela J Schreiner, Kelly A Volcik, Xingbin Wang, Salim Yusuf, Alan B Zonderland, Sonia S Anand, Diane M Becker, Bruce Psaty, Daniel J Rader, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Michèle M Sale, Michael Y Tsai, Ingrid B Borecki, Robert A Hegele, Sekar Kathiresan, Michael A Nalls, Herman A Taylor, Hakon Hakonarson, Suthesh Sivapalaratnam, Folkert W Asselbergs, Fotios Drenos, James G Wilson, Brendan J Keating
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50198 (2012)
Meta-analyses of European populations has successfully identified genetic variants in over 100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited. To address this, we performed dense genotyping of ∼2,000 candi
Externí odkaz: https://doaj.org/article/61a34aa47fe44caabf48c32acc494970
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4
Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI)
Autor: Lan Chen, David J. Stone, Andrew B. Singleton, Mike A. Nalls, Margaux F. Keller, Dena G. Hernandez
Publikováno v: Movement Disorders. 31:79-85
Background The Parkinson's Progression Marker Initiative is an international multicenter study whose main goal is investigating markers for Parkinson's disease (PD) progression as part of a path to a treatment for the disease. This manuscript describ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f7d11bf9e54c045b6947b8956b87798
https://doi.org/10.1002/mds.26374
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5
Genetic risk and age in Parkinson's disease: Continuum not stratum
Autor: Andrew B. Singleton, Margaux F. Keller, Steven J. Lubbe, Valentina Escott-Price, Huw R. Morris, Mike A. Nalls, Nigel Melvillle Williams
Publikováno v: Movement Disorders. 30:850-854
BACKGROUND: Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset. METHODS: Genetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2217884bc5d8da6b52a03b1aa6f44e90
https://doi.org/10.1002/mds.26192
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6
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis
Autor: Dennis O. Mook-Kanamori, Rehan Qayyum, Lisa R. Yanek, Luigi Ferrucci, Min-Lee Yang, David J. Stott, P. Eline Slagboom, Jin Li, Santhi K. Ganesh, Vera Grossmann, Myriam Fornage, Edith Hofer, Lewis C. Becker, Lenore J. Launer, Albert V. Smith, Brendan J. Keating, Frank J. A. van Rooij, Albert Hofman, Jun Li, Michiaki Kubo, Christian Mueller, Stella Trompet, Qiong Yang, Andrew D. Johnson, Zhao Chen, Robert J. Klein, Luanne L. Peters, Amy J. Lambert, Reinhold Schmidt, Eirini Trompouki, Kenneth Rice, Josef Coresh, Naoyuki Kamatani, Vilmundur Gudnason, Leslie A. Lange, Brian J. Abraham, Ursula M. Schick, Eric Boerwinkle, Leonard I. Zon, Bruce M. Psaty, Diane M. Becker, David Ginsburg, Gudny Eiriksdottir, Bella Hu, Mohsen Ghanbari, Dan L. Longo, Cornelia M. van Duijn, Oscar H. Franco, Beverly M. Snively, Margaux F. Keller, L. Adrienne Cupples, Yukinori Okada, James E. Hayes, Ian Ford, Jack M. Guralnik, Koichi Matsuda, J. Wouter Jukema, André G. Uitterlinden, Yoichiro Kamatani, Helena Schmidt, James G. Wilson, Michelle K. Evans, Tanja Zeller, Alan B. Zonderman, Fuu Jen Tsai, Yasaman Saba, Daniel Levy, Philipp S. Wild, Paul M. Ridker, Jaden Yang, Jer-Yuarn Wu, Janine F. Felix, Mike A. Nalls, Christopher J. O'Donnell, Karl C. Desch, Caroline S. Fox, Jennifer A. Brody, Alexander P. Reiner, Avik Choudhuri, Ayse Bilge Ozel, Abbas Dehghan, Andrew P. Morris, Ruifang Li-Gao, Daniel I. Chasman, Tamara B. Harris, Audrey Y. Chu, Toshiko Tanaka, Charles Kooperberg, Hua Tang, Song Yang, Yi Zhou, Sun Ha Jee, Kushang V. Patel, James S. Floyd, Atsushi Takahashi, Yuan-Tsong Chen, Ming-Huei Chen, Jerome I. Rotter, Li Ching Chang, Chien-Hsiun Chen
Publikováno v: The American Journal of Human Genetics
AMERICAN JOURNAL OF HUMAN GENETICS
American journal of human genetics, vol 100, iss 1
American Journal of Human Genetics, 100(1), 51-63. Cell Press
American Journal of Human Genetics, 100(1), 51-63
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African anc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9899f49c26e70e49d421c0a97de1411
https://doi.org/10.1016/j.ajhg.2016.11.016
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7
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: A genome-wide association study of 13,372 participants
Autor: Christopher Newton-Cheh, Sathanur R. Srinivasan, Jerome I. Rotter, Luigi Ferrucci, Alvaro Alonso, Yongmei Liu, Renate B. Schnabel, Tandaw E. Samdarshi, Margaux F. Keller, Marian C. Limacher, Takaaki Tanaka, J. C. Bis, Ervin R. Fox, Omer T. Njajou, Dina N. Paltoo, Gerardo Heiss, Patrick T. Ellinor, Zhu Ming Zhang, AB Singleton, Christy L. Avery, Gang Li, Michele K. Evans, Dan E. Arking, Jennifer G. Robinson, Kari E. North, Mike A. Nalls, Anne M. Butler, Sarah G. Buxbaum, Gregory M. Marcus, A.B. Newman, Ermeg L. Akylbekova, Maurizio Trevisan, Alan B. Zonderman, David S. Siscovick, P. Miguel Quibrera, Wei Chen, Herman A. Taylor, Eric A. Whitsel, Jared W. Magnani, Nona Sotoodehnia, Alexander P. Reiner, Sarah S. Murray, Rajat Deo, Steven A. Lubitz, Bruce M. Psaty, Emelia J. Benjamin, Kathleen F. Kerr, Susan R. Heckbert, J. G. Smith, Lin Y. Chen, Reena Mehra, Susan Redline, Daniel S. Evans, Nicholas J. Schork, Steve Cummings, Wen-Chi Hsueh, Gerald S. Berenson, Elsayed Z. Soliman, Erin N. Smith
Publikováno v: Heart rhythm, vol 10, iss 3
Background Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ad50677f27e8ae31063942801a0f7a
https://doi.org/10.1016/j.hrthm.2012.11.014
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8
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin
Autor: David Couper, Lynne E. Wagenknecht, Lawrence F. Bielak, Uma Nayak, Xiuqing Guo, Sanjay R. Patel, Richard A. Jensen, Nora Franceschini, Loren L. Armstrong, Mark O. Goodarzi, Mario Sims, Michael A. Province, Edmond K. Kabagambe, Leonard Lipovich, Ronald M. Krauss, Mary Cushman, Donald W. Bowden, Adebowale Adeyemo, Man Li, Joseph A.C. Delaney, Xiaohui Li, Guanjie Chen, Margaux F. Keller, Bianca Porneala, Ruth J. F. Loos, Iva Miljkovic, Donna K. Arnett, Jingmin Liu, Todd L. Edwards, Yingchang Lu, Denis Rybin, Yii-Der Ida Chen, Patricia A. Peyser, Abel N. Kho, Brian E. Cade, Adolfo Correa, Kyle J. Gaulton, Jerome I. Rotter, Tamara B. Harris, Andrew J. Karter, Amy R. Bentley, M. Geoffrey Hayes, Elizabeth Selvin, Jose C. Florez, John D. Eicher, Myriam Fornage, Michele K. Evans, Xiaofeng Zhu, Kent D. Taylor, Wei-Min Chen, William L. Lowe, Andrew P. Morris, Ching-Ti Liu, Thomas H. Mosley, Jie Yao, Mike A. Nalls, Yongmei Liu, Josée Dupuis, David S. Siscovick, Aaron Leong, Marguerite R. Irvin, Jennifer A. Smith, Min A. Jhun, Alan B. Zonderman, Marco Dauriz, Dana C. Crawford, Hara Kazuo, Maggie C.Y. Ng, Charles Agyemang, Lisa R. Yanek, Luigi Ferrucci, Mary P. Wren, Kari E. North, Eric Boerwinkle, Salman M. Tajuddin, Charles N. Rotimi, Simin Liu, Andrew D. Johnson, Erwin P. Bottinger, Michèle M. Sale, Diane M. Becker, James B. Meigs, Leslie A. Lange, Laura J. Rasmussen-Torvik, Joseph M. Zmuda, Mary L. Biggs, Carl D. Langefeld, Jingling Liang, Kenneth Rice, Aeilko H. Zwinderman, Dhananjay Vaidya, Nicholette D. Palmer, Jorge R. Kizer, Anne M. Drolet, Sharon L.R. Kardia, James G. Wilson, Sridharan Raghavan, W. H. Linda Kao, Alan L. Patrick, Jaeyoung Hong, James S. Pankow, Sarah C. Stallings, Wei Zhao, Yi Ping Fu, Toshiko Tanaka, Stephen S. Rich, Julie T. Ziegler, Bruce M. Psaty, Daniel S. Evans, Marieke B. Snijder, Omri Gottesman, Nisa M. Maruthur, Ping An, Jennifer A. Pacheco
Publikováno v: American journal of human genetics, 99(1), 56-75. Cell Press
AMERICAN JOURNAL OF HUMAN GENETICS
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261ec8055b3297ed9b8cb53e107a6576
https://pure.amc.nl/en/publications/transethnic-metaanalysis-and-functional-annotation-illuminates-the-genetic-architecture-of-fasting-glucose-and-insulin(25963e94-c4bf-4c19-81b6-02f5f7aebf2d).html
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9
Candidate Gene Association Study of BMI-Related Loci, Weight, and Adiposity in Old Age
Autor: Anne B. Newman, Melissa Garcia, Mike A. Nalls, Vilmundur Gudnason, Gregory J. Tranah, Tamara B. Harris, Margaux F. Keller, Frances A. Tylavsky, Stephen B. Kritchevsky, Gudny Eiriksdottir, Rachel A. Murphy
Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:661-666
Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)–associated S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87c3f44b08a860ee9837f99a3bed89c
https://doi.org/10.1093/gerona/gls227
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10
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians
Autor: Jerome I. Rotter, Panos Deloukas, Caren E. Smith, Frida Renström, Marju Orho-Melander, David S. Siscovick, Amanda M. Fretts, Frank B. Hu, Ulrika Ericson, George Dedoussis, Jari Lahti, Kari E. North, Emily Sonestedt, Ioanna P. Kalafati, Ingrid B. Borecki, Mika Kähönen, Mike A. Nalls, Julius S. Ngwa, Frank J. A. van Rooij, James B. Meigs, Tibor V. Varga, Ani Manichaikul, Edith H. van den Hooven, Chao-Qiang Lai, Albert Hofman, Vera Mikkilä, Terho Lehtimäki, Anna Maija Tiainen, Ilkka Seppälä, Kenneth J. Mukamal, Bruce M. Psaty, Kenneth Rice, Mariaelisa Graff, Denise K. Houston, Maria Dimitriou, Luc Djoussé, Jack L. Follis, Stavroula Kanoni, Jose M. Ordovas, Donna K. Arnett, Satu Männistö, Jessica C. Kiefte-de Jong, Rozenn N. Lemaitre, Alexis C. Frazier-Wood, Dariush Mozaffarian, Ingegerd Johansson, Jennifer A. Nettleton, Oscar H. Franco, Yongmei Liu, Mary K. Wojczynski, Nicola M. McKeown, André G. Uitterlinden, L. Adrienne Cupples, James S. Pankow, Mia-Maria Perälä, Mary F. Feitosa, Melissa E. Garcia, Paul W. Franks, Johan G. Eriksson, Olli T. Raitakari, Margaux F. Keller, Michael A. Province
Publikováno v: The American journal of clinical nutrition, vol 102, iss 5
American Journal of Clinical Nutrition, 102(5), 1266-1278. American Society for Nutrition
Europe PubMed Central
BackgroundRecent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.Obj
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72852e6585da7ccf2075a82cbfe7823
https://escholarship.org/uc/item/5p84j9s2
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