Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Margaryta Babych"'
Autor:
Mathilde Fortier, Mélanie Côté-Cyr, Vy Nguyen, Margaryta Babych, Phuong Trang Nguyen, Roger Gaudreault, Steve Bourgault
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes. Therapeutic interventions targeting IAPP amyloidogenesis, wh
Externí odkaz:
https://doaj.org/article/ffea88f71a8c4e1e8dd62149cfd92b4f
Autor:
Soultan Al-Halifa, Ximena Zottig, Margaryta Babych, Mélanie Côté-Cyr, Steve Bourgault, Denis Archambault
Publikováno v:
Nanomaterials, Vol 10, Iss 10, p 1981 (2020)
Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines. Recent studies have shown that by conjugating an antigenic determinant to a se
Externí odkaz:
https://doaj.org/article/0bbde499a5894b51aba997425af7ae32
Autor:
Lekha Sleno, Noé Quittot, Steve Bourgault, Makan Golizeh, Margaryta Babych, Phuong Trang Nguyen, Nadjib Kihal, Mélanie Côté-Cyr
Publikováno v:
Biochemistry. 60:2285-2299
The accumulation of insoluble amyloids in the pancreatic islets is a pathological hallmark of type II diabetes and correlates closely with the loss of β-cell mass. The predominant component of these amyloid deposits is the islet amyloid polypeptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68e6162268f572da12868617136e6ec
https://doi.org/10.1021/acs.biochem.1c00308
https://doi.org/10.1021/acs.biochem.1c00308
Autor:
Mathew, Sebastiao, Margaryta, Babych, Noé, Quittot, Kiran, Kumar, Alexandre A, Arnold, Isabelle, Marcotte, Steve, Bourgault
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865:184118
Numerous pathophysiological conditions are associated with the misfolding and aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which this process leads to cellular dysfunction remain elusive, though several hypotheses point t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6268a1907debf61b767c2f293184e6d
https://doi.org/10.1016/j.bbamem.2022.184118
https://doi.org/10.1016/j.bbamem.2022.184118
Autor:
Phuong Trang Nguyen, Margaryta Babych, Steve Bourgault, Noé Quittot, Mathilde Fortier, Mathew Sebastiao
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(2)
Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated GAGs are known for their propensity to promote the self-assembly of numerous amyloidogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d5712724718f6c2c1031d0eeec587d
https://pubmed.ncbi.nlm.nih.gov/33475205
https://pubmed.ncbi.nlm.nih.gov/33475205
Autor:
Margaryta Babych, Ranveer Palia, Steve Bourgault, Matthew J. Harrington, Tobias Priemel, Christopher J. Thibodeaux
Publikováno v:
Proc Natl Acad Sci U S A
Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace in medical adhesives, tissue scaffolds, and advanced smart polymers. Yet, the complex redox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4376e96c63eff9bd0f8eed61379633
https://europepmc.org/articles/PMC7149395/
https://europepmc.org/articles/PMC7149395/
Publikováno v:
Immunobiology. 225(4)
By modulating specific immune responses against antigens, adjuvants are used in many vaccine preparations to enhance protective immunity. The C-terminal domain of the protein P97 (P97c) of Mycoplasma hyopneumoniae, which is the etiologic agent of por
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f67ce5c4ae0c0dfcf2def3f48513a0
https://pubmed.ncbi.nlm.nih.gov/32747018
https://pubmed.ncbi.nlm.nih.gov/32747018
Autor:
Laurie Gauthier, Steve Bourgault, Margaryta Babych, Jessica Dion, Geneviève Bertheau-Mailhot, Ximena Zottig, Denis Archambault
Publikováno v:
Nanoscale. 10:19547-19556
The design of nanoparticles exposing a high density of antigens constitutes a promising strategy to address safety concerns of conventional life-attenuated vaccines as well as to increase the immunogenicity of subunit vaccines. In this study, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c18628ed6395b22642729c4e022b4e
https://doi.org/10.1039/c8nr05948a
https://doi.org/10.1039/c8nr05948a
Autor:
Soultan Al-Halifa, Steve Bourgault, Ximena Zottig, Noé Quittot, Margaryta Babych, Denis Archambault
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 15(33)
Peptides that self-assemble into cross-β-sheet amyloid structures constitute promising building blocks to construct highly ordered proteinaceous materials and nanoparticles. Nevertheless, the intrinsic polymorphism of amyloids and the difficulty of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53d3d31b33ceeae2e5b7ae5b78caf57
https://pubmed.ncbi.nlm.nih.gov/31268238
https://pubmed.ncbi.nlm.nih.gov/31268238
Autor:
Ximena Zottig, Steve Bourgault, Soultan Al-Halifa, Denis Archambault, Mélanie Côté-Cyr, Margaryta Babych
Publikováno v:
Nanomaterials
Nanomaterials, Vol 10, Iss 1981, p 1981 (2020)
Volume 10
Issue 10
Nanomaterials, Vol 10, Iss 1981, p 1981 (2020)
Volume 10
Issue 10
Protein fibrils characterized with a cross-&beta
sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines. Recent studies have shown that by conjugating an antigenic determinant
sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines. Recent studies have shown that by conjugating an antigenic determinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644b38a59d602a4bfdbb043a6d249eeb
https://doi.org/10.3390/nano10101981
https://doi.org/10.3390/nano10101981