Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Margarite L. Tarrio"'
Autor:
Jenny E. Suarez-Ramirez, Margarite L. Tarrio, Kwangsin Kim, Delia A. Demers, Christine A. Biron
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The cytokine gamma interferon (IFN-γ), with antimicrobial and immunoregulatory functions, can be produced by T cells following stimulation through their T cell receptors (TCRs) for antigen. The innate cytokines type 1 IFNs and interleukin-1
Externí odkaz:
https://doaj.org/article/6fac728d72e84601be492825b4d89991
Autor:
Steven M. Opal, Margarite L. Tarrio, Anat Shirvan, Raymond Kaempfer, Alan S. Cross, Rotem Edgar, Greg Maislin, Feng Chiguang
Publikováno v:
International Journal of Peptide Research and Therapeutics. 26:1669-1683
Soft-tissue bacterial infection can progress to severe sepsis and septic shock as a result of a disproportionate inflammatory response, characterized by an excessive release of cytokines and influx of immune cells. Reltecimod (previously known as AB1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6aa76eaaeb223871bc1dc2b6b884f60
https://doi.org/10.1007/s10989-019-09974-5
https://doi.org/10.1007/s10989-019-09974-5
Innate cytokines are soluble mediators produced by a wide range of cells including innate immune and even nonimmune cells. Once engaged, specialized sensors recognizing molecular structures uniquely expressed during infection, stimulate production of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fe33af0a9b18968f816d0c35f4d3adb
https://doi.org/10.1016/b978-0-12-374279-7.14005-6
https://doi.org/10.1016/b978-0-12-374279-7.14005-6
Autor:
Maria Frank-Kamenetsky, Vera M. Ruda, Margarite L. Tarrio, Andrew H. Lichtman, Kyu Yeon Hur, Ann-Hwee Lee, Laurie H. Glimcher, Takao Iwawaki, Kevin Fitzgerald, Jae-Seon So, Victor Koteliansky
Publikováno v:
Cell Metabolism. 16:487-499
SummaryXBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide range of physiological and pathological processes. XBP1 ablation in liver causes profound hypolipidemia in mice, highlighting its critical role in lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfba1cb980fddc17dd4a79c04b139d6e
https://doi.org/10.1016/j.cmet.2012.09.004
https://doi.org/10.1016/j.cmet.2012.09.004
Autor:
Nir Grabie, Margarite L. Tarrio, Andrew H. Lichtman, Kevin Croce, Elena Maganto-Garcia, Gabriel K. Griffin, Francis W. Luscinskas, Pilar Alcaide, Gail Newton, Veronica Azcutia, De Xiu Bu
Publikováno v:
The Journal of Immunology. 188:6287-6299
IL-17A (IL-17) is the signature cytokine produced by Th17 cells and has been implicated in host defense against infection and the pathophysiology of autoimmunity and cardiovascular disease. Little is known, however, about the influence of IL-17 on en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7d8308f0e96a633daa17b7f3ff0b9b
https://doi.org/10.4049/jimmunol.1200385
https://doi.org/10.4049/jimmunol.1200385
Publikováno v:
The Journal of Immunology. 188:4876-4884
PD-1, a member of the CD28 family of immune regulatory molecules, is expressed on activated T cells, interacts with its ligands, PD-L1/B7-H1 and PD-L2/B7-DC, on other cells, and delivers inhibitory signals to the T cell. We studied the role of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1d684a8e078488dbd56142ee91a3e2
https://doi.org/10.4049/jimmunol.1200389
https://doi.org/10.4049/jimmunol.1200389
Autor:
Nir Grabie, Kevin Croce, Elena Maganto-Garcia, Andrew H. Lichtman, Margarite L. Tarrio, De-xiu Bu, Francis W. Luscinskas, Gabriel K. Griffin, Pilar Alcaide, Gail Newton
Publikováno v:
The Journal of Immunology. 187:3521-3529
The ability of regulatory T cells (Treg) to traffic to sites of inflammation supports their role in controlling immune responses. This feature supports the idea that adoptive transfer of in vitro expanded human Treg could be used for treatment of imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6a1e7310ff7572db15e135bce94665
https://doi.org/10.4049/jimmunol.1003947
https://doi.org/10.4049/jimmunol.1003947
Publikováno v:
Circulation. 124:185-195
Background— Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression. Methods and Resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9051fc8834186141a892a183422ef0c
https://doi.org/10.1161/circulationaha.110.006411
https://doi.org/10.1161/circulationaha.110.006411
Autor:
Arlene H. Sharpe, Gordon J. Freeman, Goro Tajima, James A. Lederer, De-xiu Bu, Andrew H. Lichtman, Margarite L. Tarrio, Elena Maganto-Garcia, Petr Jarolim, George Stavrakis
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1100-1107
Objective— Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals on interaction with its 2 ligands, PD-L1 and PD-L2. We studied the contribution of the PD-1 pathway to regulation of T cells that promote a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fb331d99ea4b29e437e9661e7839fd
https://doi.org/10.1161/atvbaha.111.224709
https://doi.org/10.1161/atvbaha.111.224709
Autor:
Yuzhi Zhang, Hiroyuki Yamazaki, Guillermo García-Cardeña, Zachary A. Pepper-Cunningham, Andrew H. Lichtman, Petr Jarolim, Masanori Aikawa, Elena Maganto-Garcia, George Stavrakis, Nir Grabie, De-xiu Bu, Margarite L. Tarrio
Publikováno v:
Journal of Clinical Investigation. 120:1961-1970
The transcription factor Krüppel-like factor 2 (KLF2) is required for the quiescent and migratory properties of naive T cells. Statins, a class of HMG-CoA reductase inhibitors, display pleiotropic immunomodulatory effects that are independent of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6ae9aa99bc4297f48242f75aa19030
https://doi.org/10.1172/jci41384
https://doi.org/10.1172/jci41384