Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Margarite D. Matossian"'
Autor:
Shengli Dong, Margarite D. Matossian, Hassan Yousefi, Maninder Khosla, Bridgette M. Collins-Burow, Matthew E. Burow, Suresh K. Alahari
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Triple-negative breast cancers (TNBCs) are aggressive forms of breast cancer and tend to grow and spread more quickly than most other types of breast cancer. TNBCs can neither be targeted by hormonal therapies nor the antibody trastuzumab th
Externí odkaz:
https://doaj.org/article/ba3cd5975dec4de2bb4cc4c76dd42728
Autor:
Shengli Dong, Hassan Yousefi, Isabella Van Savage, Samuel C. Okpechi, Maryl K. Wright, Margarite D. Matossian, Bridgette M. Collins-Burow, Matthew E. Burow, Suresh K. Alahari
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)
Abstract Background Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. Androgen receptor (AR)
Externí odkaz:
https://doaj.org/article/c21df2546bf34c64b07e78a26f6cb56b
Autor:
Connor T. King, Margarite D. Matossian, Jonathan J. Savoie, Khoa Nguyen, Maryl K. Wright, C. Ethan Byrne, Steven Elliott, Hope E. Burks, Melyssa R. Bratton, Nicholas C. Pashos, Bruce A. Bunnell, Matthew E. Burow, Bridgette M. Collins-Burow, Elizabeth C. Martin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Liver kinase B1 (LKB1) is a potent tumor suppressor that regulates cellular energy balance and metabolism as an upstream kinase of the AMP-activated protein kinase (AMPK) pathway. LKB1 regulates cancer cell invasion and metastasis in multiple cancer
Externí odkaz:
https://doaj.org/article/1fca8d14259943c0915a7352775e251d
Autor:
Margarite D. Matossian, Alexandra A. Giardina, Maryl K. Wright, Steven Elliott, Michelle M. Loch, Khoa Nguyen, Arnold H. Zea, Frank H. Lau, Krzysztof Moroz, Adam I. Riker, Steven D. Jones, Elizabeth C. Martin, Bruce A. Bunnell, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow
Publikováno v:
Women's Health Reports, Vol 1, Iss 1, Pp 383-392 (2020)
Despite a decline in overall incidence rates for cancer in the past decade, due in part to impressive advancements in both diagnosis and treatment, breast cancer (BC) remains the leading cause of cancer-related deaths in women. BC alone accounts for
Externí odkaz:
https://doaj.org/article/68c5571fd2024721a83ad7f161d55ff0
Autor:
Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101046- (2021)
The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT i
Externí odkaz:
https://doaj.org/article/741a151b8f16497b82667f09411e6156
Autor:
Rachel A. Sabol, Annie C. Bowles, Alex Côté, Rachel Wise, Benjamen O’Donnell, Margarite D. Matossian, Fokhrul M. Hossain, Hope E. Burks, Luis Del Valle, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow, Bruce A. Bunnell
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background Breast cancer is the second leading cause of cancer deaths in the USA. Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer with high rates of metastasis, tumor recurrence, and resistance to the
Externí odkaz:
https://doaj.org/article/9f1f4b0bed824b048e78ed329b6f785e
Autor:
Margarite D. Matossian, Hope E. Burks, Steven Elliott, Van T. Hoang, Annie C. Bowles, Rachel A. Sabol, Bahia Wahba, Muralidharan Anbalagan, Brian Rowan, Mohamed E. Abazeed, Bruce A. Bunnell, Krzysztof Moroz, Lucio Miele, Lyndsay V. Rhodes, Steven D. Jones, Elizabeth C. Martin, Bridgette M. Collins-Burow, Matthew E. Burow
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identification, thereby potenti
Externí odkaz:
https://doaj.org/article/a5b762a9f33140d0bc286cacff660560
Autor:
Rakesh Gurrala, C. Ethan Byrne, Loren M. Brown, Rafael Felix P. Tiongco, Margarite D. Matossian, Jonathan J. Savoie, Bridgette M. Collins-Burow, Matthew E. Burow, Elizabeth C. Martin, Frank H. Lau
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Solid tumor progression is significantly influenced by interactions between cancer cells and the surrounding extracellular matrix (ECM). Specifically, the cancer cell-driven changes to ECM fiber alignment and collagen deposition impact tumor growth a
Externí odkaz:
https://doaj.org/article/637f077b8cbc477aab64cef45f097cfd
Autor:
Van T. Hoang, Margarite D. Matossian, Deniz A. Ucar, Steven Elliott, Jacqueline La, Maryl K. Wright, Hope E. Burks, Aaron Perles, Fokhrul Hossain, Connor T. King, Valentino E. Browning, Jacob Bursavich, Fang Fang, Luis Del Valle, Akshita B. Bhatt, Jane E. Cavanaugh, Patrick T. Flaherty, Muralidharan Anbalagan, Brian G. Rowan, Melyssa R. Bratton, Kenneth P. Nephew, Lucio Miele, Bridgette M. Collins-Burow, Elizabeth C. Martin, Matthew E. Burow
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Conventional mitogen-activated protein kinase (MAPK) family members regulate diverse cellular processes involved in tumor initiation and progression, yet the role of ERK5 in cancer biology is not fully understood. Triple-negative breast cancer (TNBC)
Externí odkaz:
https://doaj.org/article/200b22265dbe421ba0329786d0153f68
Autor:
Akshita B. Bhatt, Saloni Patel, Margarite D. Matossian, Deniz A. Ucar, Lucio Miele, Matthew E. Burow, Patrick T. Flaherty, Jane E. Cavanaugh
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 183 (2021)
Extracellular signal-regulated kinase (ERK5) is an essential regulator of cancer progression, tumor relapse, and poor patient survival. Epithelial to mesenchymal transition (EMT) is a complex oncogenic process, which drives cell invasion, stemness, a
Externí odkaz:
https://doaj.org/article/8af4ad0094544d1bbf201b484f248a49