In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside

Autor: Estefanía Burgos-Morón, Nuria Pastor, Manuel Luis Orta, Julio José Jiménez-Alonso, Carlos Palo-Nieto, Margarita Vega-Holm, José Manuel Vega-Pérez, Fernando Iglesias-Guerra, Santiago Mateos, Miguel López-Lázaro, José Manuel Calderón-Montaño

Publikováno v: Biomedicines, Vol 10, Iss 1, p 41 (2021)

We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-β-D-galactopyranoside (Az

Externí odkaz: https://doaj.org/article/37dae076adea43c08ab9a50a65ba6608

Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes

Autor: Sarah Mazzotta, Gabriele Carullo, Aniello Schiano Moriello, Pietro Amodeo, Vincenzo Di Marzo, Margarita Vega-Holm, Rosa Maria Vitale, Francesca Aiello, Antonella Brizzi, Luciano De Petrocellis

Publikováno v: Marine Drugs, Vol 18, Iss 10, p 519 (2020)

Labdane diterpenes are widespread classes of natural compounds present in variety of marine and terrestrial organisms and plants. Many of them represents “natural libraries” of compounds with interesting biological activities due to differently f

Externí odkaz: https://doaj.org/article/52549e1068a54e1d8102f109a63c20e6

In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside

Autor: Estefanía Burgos-Morón, Nuria Pastor, Manuel Luis Orta, Julio José Jiménez-Alonso, Carlos Palo-Nieto, Margarita Vega-Holm, José Manuel Vega-Pérez, Fernando Iglesias-Guerra, Santiago Mateos, Miguel López-Lázaro, José Manuel Calderón-Montaño

Publikováno v: Biomedicines
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Biomedicines, Vol 10, Iss 41, p 41 (2022)
Biomedicines; Volume 10; Issue 1; Pages: 41

We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-β-D-galactopyranoside (Az

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34d07755d981072d1c578512623bbcc
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469184

Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol

Autor: Sarah Mazzotta, Fernando Iglesias-Guerra, Marta Carretero-Ledesma, María Del Rosario García-Lozano, Jerónimo Pachón, Francesca Aiello, Javier Sánchez-Céspedes, José M. Vega-Pérez, Judith Berastegui-Cabrera, Margarita Vega-Holm

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla

Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62fcbcd457cde721f691f0f15ca8876
http://hdl.handle.net/10261/265548

Serinol-Based Benzoic Acid Esters as New Scaffolds for the Development of Adenovirus Infection Inhibitors: Design, Synthesis, and

Autor: Sarah, Mazzotta, Judith, Berastegui-Cabrera, Gabriele, Carullo, Margarita, Vega-Holm, Marta, Carretero-Ledesma, Lara, Mendolia, Francesca, Aiello, Fernando, Iglesias-Guerra, Jerónimo, Pachón, José Manuel, Vega-Pérez, Javier, Sánchez-Céspedes

Publikováno v: ACS infectious diseases. 7(6)

Over the years, human adenovirus (HAdV) has progressively been recognized as a significant viral pathogen. Traditionally associated with self-limited respiratory, gastrointestinal, and conjunctival infections, mainly in immunocompromised patients, HA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66b29a3d1d877fe416d15d2dbe19ccaa
https://pubmed.ncbi.nlm.nih.gov/33073569