Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Margarita V, Chibalina"'
Autor:
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostat
Externí odkaz:
https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe8637
Autor:
Linford J.B. Briant, Michael S. Dodd, Margarita V. Chibalina, Nils J.G. Rorsman, Paul R.V. Johnson, Peter Carmeliet, Patrik Rorsman, Jakob G. Knudsen
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3300-3311 (2018)
Summary: Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose sup
Externí odkaz:
https://doaj.org/article/5968a2edf07a4115802dca31633e2c1c
Autor:
Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, Andrei I. Tarasov, Quan Zhang, Eduardo Rebelato, Nils J.G. Rorsman, Rafael Martín-del-Río, Amy Lewis, Gizem Özkan, Hyun Woong Do, Peter Spégel, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Benedikt M. Kessler, Christopher W. Pugh, Jorge Tamarit-Rodriguez, Hindrik Mulder, Anne Clark, Norma Frizzell, Tomoyoshi Soga, Frances M. Ashcroft, Andrew Silver, Patrick J. Pollard, Patrik Rorsman
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3135-3148 (2017)
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intoleran
Externí odkaz:
https://doaj.org/article/05d52d7c48f340449106e32e0dd4ebf7
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2088-2101 (2017)
APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and m
Externí odkaz:
https://doaj.org/article/f33ebf36f3844a7db12a9ad1e1d7cd85
Autor:
Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolis
Externí odkaz:
https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1
Publikováno v:
Traffic (Copenhagen, Denmark)
The polarized trafficking of membrane proteins into the leading edge of the cell is an integral requirement for cell migration. Myosin VI and its interacting protein optineurin have previously been shown to operate in anterograde trafficking pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73e5fdae9745b9a7af61aca251de301
Autor:
Elisa, Vergari, Geoffrey, Denwood, Albert, Salehi, Quan, Zhang, Julie, Adam, Ahmed, Alrifaiy, Ingrid, Wernstedt Asterholm, Anna, Benrick, Margarita V, Chibalina, Lena, Eliasson, Claudia, Guida, Thomas G, Hill, Alexander, Hamilton, Reshma, Ramracheya, Frank, Reimann, Nils J G, Rorsman, Ioannis, Spilliotis, Andrei I, Tarasov, Jonathan N, Walker, Patrik, Rorsman, Linford J B, Briant
Publikováno v:
Nature metabolism
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells1. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon s
Autor:
Matthew Harris, Joana Real, Margarita V. Chibalina, Anna Benrick, Laura J. McCulloch, Caroline Miranda, Davide Basco, Frank Reimann, Graham Ladds, Reshma Ramracheya, A Clark, Belén Chanclón, Joely A. Kellard, P Rorsman, Claudia Guida, Nils J.G. Rorsman, M Shigeto, Bernard Thorens, Ho Yan Yeung, Ingrid Wernstedt Asterholm
SummaryThe incretin hormone glucagon-like peptide 1(7-36) (GLP-1(7-36)) stimulates insulin and inhibits glucagon secretion. The mechanisms by which GLP-1 suppresses glucagon release are unclear as glucagon-secreting α-cells express GLP-1 receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18310a2dc2d5bdfd2ce0d444729c4b0
https://doi.org/10.1101/785667
https://doi.org/10.1101/785667
Autor:
Dou H, Quan Zhang, Alejandro González, Margarita V. Chibalina, A Clark, Yusuke Moritoh, Patrik Rorsman, Miranda C, Paul Johnson, C E Chapman, M Shigeto, Matthias Braun, Briant Ljb, Reshma Ramracheya
Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b337c04aed192e2479186c0a9dc63a3
https://ora.ox.ac.uk/objects/uuid:85d072ec-8e53-4c26-8371-e01f50580a22
https://ora.ox.ac.uk/objects/uuid:85d072ec-8e53-4c26-8371-e01f50580a22
Publikováno v:
Scientific Reports