Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Margarita Trejo-Morales"'
Autor:
Edward Rockenstein, Cassia R Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquert, Margarita Trejo-Morales, Brian Spencer, Eliezer Masliah
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121570 (2015)
Tauopathies are a group of disorders leading to cognitive and behavioral impairment in the aging population. While four-repeat (4R) Tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and Alzheimer's disease, three-repe
Externí odkaz:
https://doaj.org/article/1433abc2c10e4f0c846ddeb51557504b
Autor:
Eliezer Masliah, Paola Picotti, Christina Patrick, Fred H. Gage, Margarita Trejo-Morales, Jürgen Winkler, Michael Mante, Edward Rockenstein, Anthony Adame, Kiren Ubhi, Cassia R. Overk, Poul Henning Jensen, Silke Nuber, Silvia Campioni, Beate Winner, Roland Riek, Juan Gerez
Publikováno v:
BRAIN
Brain: A Journal of Neurology, 137
Brain : a journal of neurology
Rockenstein, E, Nuber, S, Overk, C R, Ubhi, K, Mante, M, Patrick, C, Adame, A, Trejo-Morales, M, Gerez, J, Picotti, P, Jensen, P H, Campioni, S, Riek, R, Winkler, J, Gage, F H, Winner, B & Masliah, E 2014, ' Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo ', Brain, vol. 137, no. Pt 5, pp. 1496-513 . https://doi.org/10.1093/brain/awu057
Brain: A Journal of Neurology, 137
Brain : a journal of neurology
Rockenstein, E, Nuber, S, Overk, C R, Ubhi, K, Mante, M, Patrick, C, Adame, A, Trejo-Morales, M, Gerez, J, Picotti, P, Jensen, P H, Campioni, S, Riek, R, Winkler, J, Gage, F H, Winner, B & Masliah, E 2014, ' Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo ', Brain, vol. 137, no. Pt 5, pp. 1496-513 . https://doi.org/10.1093/brain/awu057
In Parkinson's disease and dementia with Lewy bodies, α-synuclein aggregates to form oligomers and fibrils; however, the precise nature of the toxic α-synuclein species remains unclear. A number of synthetic α-synuclein mutations were recently cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae69328f71f902c312d7ed60254f826
Autor:
Eliezer Masliah, Amy Paulino, Karin Ledolter, Paula Desplats, Wolfgang Wrasidlo, Igor F. Tsigelny, Dieter Meier, Åge A. Skjevik, Margarita Trejo-Morales, Brian Spencer, Robert Konrat, Chunni Zhu, Garima Dutta, Simona Eleuteri, Marie-Françoise Chesselet, Tania Gonzalez-Ruelas, Cassia R. Overk, Edward Rockenstein, Thomas C. Schwarz, Diana L. Price, Douglas W. Bonhaus, Valentina L. Kouznetsova, Herbert Moessler, Stefan Winter
Publikováno v:
Brain : a journal of neurology, vol 139, iss Pt 12
Abnormal accumulation and propagation of the neuronal protein α-synuclein has been hypothesized to underlie the pathogenesis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Here we report a de novo-developed compound (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e17d784387b62c9ca849ff394fe12f
https://escholarship.org/uc/item/3dk4t6f7
https://escholarship.org/uc/item/3dk4t6f7
Autor:
Edward Rockenstein, Eliezer Masliah, Anthony Adame, Margarita Trejo-Morales, Elvira Valera, Brian Spencer
Publikováno v:
Molecular neurodegeneration, vol 10, iss 1
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, resistance to dopamine therapy, ataxia, autonomic dysfunction, and pathological accumulation of α-synuclein (α-syn) in oligodendrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3293a83299d5d9dd4b249cc5c1ff0ee8
https://doi.org/10.1186/s13024-015-0043-6
https://doi.org/10.1186/s13024-015-0043-6
Autor:
Eliezer Masliah, Anthony Adame, Edward Rockenstein, Christina Patrick, Margarita Trejo-Morales, Michael Mante, Brian Spencer, Cassia R. Overk, Kiren Ubhi, Alejandro Bisquert
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0121570 (2015)
PLoS ONE, Vol 10, Iss 3, p e0121570 (2015)
Tauopathies are a group of disorders leading to cognitive and behavioral impairment in the aging population. While four-repeat (4R) Tau is more abundant in corticobasal degeneration, progressive supranuclear palsy, and Alzheimer's disease, three-repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453f79dd7d62fd2d46d8003c69dd3c5a
https://pubmed.ncbi.nlm.nih.gov/25803611
https://pubmed.ncbi.nlm.nih.gov/25803611
Autor:
Cassia R. Overk, Igor F. Tsigelny, Eliezer Masliah, Sarah Michael, Jerry P. Greenberg, Wolfgang Wrasidlo, Tania Gonzalez, Valentina L. Kouznetsova, Yuriy Sharikov, Paula Desplats, Margarita Trejo-Morales
Publikováno v:
Journal of Alzheimer's disease : JAD. 39(3)
Alzheimer's disease (AD) is associated with the formation of toxic amyloid-β (Aβ)42 oligomers, and recent evidence supports a role for Aβ dimers as building blocks for oligomers. Molecular dynamics simulation studies have identified clans for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b57edc82a7f8fea62f17f6b633b7495
https://pubmed.ncbi.nlm.nih.gov/24240640
https://pubmed.ncbi.nlm.nih.gov/24240640
Autor:
Rebecca Ruf, Margarita Trejo-Morales, Christina Patrick, Edward Rockenstein, Cristian L. Achim, Eliezer Masliah, Wilmar Dumaop, Leslie Crews
Publikováno v:
Crews, Leslie; Ruf, Rebecca; Patrick, Christina; Dumaop, Wilmar; Trejo-Morales, Margarita; Achim, Cristian L; et al.(2011). Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders. Molecular Neurodegeneration, 6(1), 67. doi: http://dx.doi.org/10.1186/1750-1326-6-67. Retrieved from: http://www.escholarship.org/uc/item/4m13s31f
Molecular Neurodegeneration, Vol 6, Iss 1, p 67 (2011)
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 6, Iss 1, p 67 (2011)
Molecular Neurodegeneration
Background Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain. Abnormal activation of CDK5 is associated with neurodegenerative disorders, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f8d3d011388bd235b62eedd29901f
http://www.escholarship.org/uc/item/4m13s31f
http://www.escholarship.org/uc/item/4m13s31f
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 63(9)
Decreased skeletal muscle mass and proportion of fast-twitch glycolytic fibers are well-documented correlates of aging; however, data on concomitant changes on capillary-to-fiber ratio (C:F) are inconsistent. We simultaneously examined fiber-type com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1c23603984cdb806d4b232f4fd4768
https://pubmed.ncbi.nlm.nih.gov/18840797
https://pubmed.ncbi.nlm.nih.gov/18840797