Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Margarita Schlackow"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A
Externí odkaz:
https://doaj.org/article/90bcdc21996641338179013236fc44d3
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Phosphorylated H2A.X is a critical chromatin marker of DNA damage repair (DDR) in higher eukaryotes. However, H2A.X gene expression remains relatively uncharacterised. Replication-dependent (RD) histone genes generate poly(A)- mRNA encoding new histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed554b1a4ade16b4d05f6cefbcd1198
http://europepmc.org/articles/PMC7807067
http://europepmc.org/articles/PMC7807067
Autor:
Federico Marini, Krishnaraj Rajalingam, Helmut Jonuleit, Margarita Schlackow, Katarzyna Bogucka, Janine Schloeder, Kerstin David, Sebastian Rosigkeit
Publikováno v:
Cancer gene therapy. 28(5)
KRAS is one of the most frequently mutated oncogenes, especially in lung cancers. Targeting of KRAS directly or the downstream effector signaling machinery is of prime interest in treating lung cancers. Here, we uncover that ERK3, a ubiquitously expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becb6145d3f80c78b75367b250299176
https://pubmed.ncbi.nlm.nih.gov/33168935
https://pubmed.ncbi.nlm.nih.gov/33168935
Publikováno v:
SSRN Electronic Journal.
In mammalian cells, endogenous small RNAs regulate gene expression in a pathway known as RNA interference (RNAi) (Hannon, 2002). RNAi can be generally categorised into post-transcriptional gene silencing (PTGS), which involves the destabilisation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c0da9e20bf88fff479a8e477ae6732
https://doi.org/10.2139/ssrn.3743227
https://doi.org/10.2139/ssrn.3743227
Autor:
Margarita Schlackow, Monika Gullerova, Kaspar Burger, Shabaz Mohammed, Svenja Hester, Martin Potts
Publikováno v:
The Journal of Cell Biology
Recent work implicated human Dicer in the DNA damage response. Burger et al. show that DNA damage induces phosphorylation of Dicer and promotes DNA repair in the nucleus.
The endoribonuclease Dicer is a key component of the human RNA interferenc
The endoribonuclease Dicer is a key component of the human RNA interferenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa6e25304de0e6729cf28cbbba35505
https://doi.org/10.1083/jcb.201612131
https://doi.org/10.1083/jcb.201612131
Publikováno v:
Nucleic Acids Research
DNA is constantly exposed to endogenous and exogenous damage. Various types of DNA repair counteract highly toxic DNA double-strand breaks (DSBs) to maintain genome stability. Recent findings suggest that the human DNA damage response (DDR) utilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b811b3e3e077d0f024cd32bd9e053012
https://pubmed.ncbi.nlm.nih.gov/30668775
https://pubmed.ncbi.nlm.nih.gov/30668775
Autor:
Margarita Schlackow, Janine Schloeder, Sebastian Rosigkeit, Katarzyna Bogucka, Helmut Jonuleit, Kerstin David, Federico Marini, Krishnaraj Rajalingam
Publikováno v:
Cancer Gene Therapy. 28:543-543
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398a5a24cf5f052f13946d30711a179c
https://doi.org/10.1038/s41417-020-00250-z
https://doi.org/10.1038/s41417-020-00250-z
Publikováno v:
Genesdevelopment. 31(21)
Nuclear gene transcription is coordinated with transcript release from the chromatin template and messenger RNA (mRNA) export to the cytoplasm. Here we describe the role of nuclear-localized kinase WNK1 (with no lysine [K] 1) in the mammalian mRNA ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46f493634da75a8e64ba36462a4da1f3
https://pubmed.ncbi.nlm.nih.gov/29196535
https://pubmed.ncbi.nlm.nih.gov/29196535
Autor:
Kinga Kamieniarz-Gdula, Margarita Schlackow, Monika Gullerova, Eleanor White, Nick J. Proudfoot
Publikováno v:
Nature structural & molecular biology
Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, its nuclear function remains obscure. Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b939674f0893a841b53db6c4cf5d056e
https://doi.org/10.1038/nsmb.2827
https://doi.org/10.1038/nsmb.2827
Publikováno v:
Nucleic Acids Research
Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e9d72c4bd0dd6127fe33feccadb4a04
https://pubmed.ncbi.nlm.nih.gov/27084937
https://pubmed.ncbi.nlm.nih.gov/27084937