Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Margarita Rodriguez-Lens"'
Autor:
Steven M. Gaulier, Dafydd R. Owen, Margarita Rodriguez-Lens, Huw Rees, Valerie A. Horne, Blanda Luzia Christa Stammen, Martin Corless, Maw Graham Nigel, Thomas Ryckmans, David W. Pearce, Ross A. Kinloch, Tracy J. Ringer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1702-1706
A number of libraries were produced to explore the potential of 2,4-diaminopyridine lead 1. The resulting diaminopyridines proved to be potent and selective delta-opioid receptor agonists. Several rounds of lead optimisation using library chemistry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4f65a97e449b1a91cdfa17bc9358fc
https://doi.org/10.1016/j.bmcl.2009.01.106
https://doi.org/10.1016/j.bmcl.2009.01.106
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Autor:
Mark L. Lewis, Kana Kon-I, Dafydd R. Owen, Tim Young, Mifune Takeuchi, Isabelle Tran, Miyako Matsumizu, Denise Harding, Helen J. Mason, Christine Anne Louise Watson, Akiko Shima, Margarita Rodriguez-Lens, Takasuke Mukaiyama
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(14)
A series of benzimidazole CB2 receptor agonists were prepared and their properties investigated. Optimisation of the three benzimidazole substituents led to the identification of compound 23, a potent CB2 full agonist (EC50 2.7 nM) with excellent sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78b1de06a8c469259fb60e4fb75e775
https://pubmed.ncbi.nlm.nih.gov/21669533
https://pubmed.ncbi.nlm.nih.gov/21669533
Autor:
Margarita Rodriguez-Lens, D. Christopher Braddock, Ai Matsuno, D. Michael Badine, Thomas Gottschalk
Publikováno v:
ChemInform. 34
The reaction of l-phenyldimethylsilyl-2-vinyl cyclopropane with aldehydes under the influence of dimethylaluminium chloride proceeds smoothly to provide skipped diene alcohols with exclusive E-olefin geometry regardless of the initial cis/trans confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0819b17dbef65846b1d0db69722d6c
https://doi.org/10.1002/chin.200323037
https://doi.org/10.1002/chin.200323037