Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Margarita Neganova"'
Autor:
Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu, Ruitai Fan
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respir
Externí odkaz:
https://doaj.org/article/8c24b26347dd4ae4a926af85aedade29
Autor:
Elena Chugunova, Elmira Gibadullina, Kirill Matylitsky, Baurat Bazarbayev, Margarita Neganova, Konstantin Volcho, Artem Rogachev, Nurgali Akylbekov, Hoang Bao Tran Nguyen, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Victor Syakaev, Alexander Burilov, Nurbol Appazov, Mukhtar Zhanakov, Leah Kuhn, Oleg Sinyashin, Igor Alabugin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 499 (2023)
Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit a broad range of biological activities. The modular
Externí odkaz:
https://doaj.org/article/e65e5cbc8125486ab59ef1ef8dbc71c1
Autor:
Margarita Neganova, Yulia Aleksandrova, Evgenii Suslov, Evgenii Mozhaitsev, Aldar Munkuev, Dmitry Tsypyshev, Maria Chicheva, Artem Rogachev, Olga Sukocheva, Konstantin Volcho, Sergey Klochkov
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1893 (2021)
Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors. Fragments of adamantane and natural terpenes
Externí odkaz:
https://doaj.org/article/1d71400901a04db7a67bc9a958131f15
Autor:
Anastasia Balakina, Tatyana Prikhodchenko, Vera Amozova, Tatyana Stupina, Victoria Mumyatova, Margarita Neganova, Ilya Yakushev, Alexey Kornev, Svyatoslav Gadomsky, Boris Fedorov, Denis Mishchenko
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1451 (2021)
In the case of various pathologies, an imbalance between ROS generation and the endogenous AOS can be observed, which leads to excessive ROS accumulation, intensification of LPO processes, and oxidative stress. For the prevention of diseases associat
Externí odkaz:
https://doaj.org/article/aa37b7e744df4a9788645c28a613a86a
Autor:
Margarita Neganova, Alexey Semakov, Yulia Aleksandrova, Ekaterina Yandulova, Sergey Pukhov, Lada Anikina, Sergey Klochkov
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 547 (2021)
Anthracycline antitumor antibiotics are one of the promising classes of chemotherapeutic agents for cancer treatment. The main deterrent to their use is high toxicity to a healthy environment, including cumulative cardiotoxicity. In our work, bipharm
Externí odkaz:
https://doaj.org/article/7343c95532954496bd0a2cf11526d427
Autor:
Ruitai Fan, Olga Sukocheva, Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Natalia Vasilieva, Alexey Semakov, Ekaterina Yandulova, Konstantin Balakin, Sergey Klochkov
Publikováno v:
Current Medicinal Chemistry. 30
Abstract: Sesquiterpene lactones are secondary plant metabolites with a wide variety of biological activities. The process of lactone conjugation to other pharmacophores can increase the efficacy and specificity of the conjugated agent effect on mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258a3d9f28974d394e21899f87bb22d2
https://doi.org/10.2174/0929867330666221125105253
https://doi.org/10.2174/0929867330666221125105253
Autor:
Elena Chugunova, Victoria Matveeva, Alena Tulesinova, Emil Iskanderov, Nurgali Akylbekov, Alexey Dobrynin, Ayrat Khamatgalimov, Nurbol Appazov, Lyazat Boltayeva, Bakhytzhan Duisembekov, Mukhtar Zhanakov, Yulia Aleksandrova, Tatyana Sashenkova, Elena Klimanova, Ugulzhan Allayarova, Anastasia Balakina, Denis Mishchenko, Alexander Burilov, Margarita Neganova
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14902
A series of novel water-soluble salts of benzofuroxans was achieved via aromatic nucleophilic substitution reaction of 4,6-dichloro-5-nitrobenzofuroxan with various amines. The salts obtained showed good effectiveness of the pre-sowing treatment of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362742460678723c01d171daa950cce8
https://pubmed.ncbi.nlm.nih.gov/36499230
https://pubmed.ncbi.nlm.nih.gov/36499230
Autor:
Yulia Aleksandrova, Kirill Chaprov, Alexandra Podturkina, Oleg Ardashov, Ekaterina Yandulova, Konstantin Volcho, Nariman Salakhutdinov, Margarita Neganova
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5842
Parkinson’s disease is the second most common neurodegenerative disease. Unfortunately, there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian potential of trans-epoxide (1S,2S,3R,4S,6R)-1-methyl-4-(prop-1-en-2-yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1a2750abe44dbf1b078d33913e3e06
https://doi.org/10.3390/ijms24065842
https://doi.org/10.3390/ijms24065842
