Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Margarita Martinez-Moczygemba"'
2
Akademický článek
Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy
Autor: Bettina Hoden, David DeRubeis, Margarita Martinez-Moczygemba, Kenneth S. Ramos, Dekai Zhang
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Lung cancer is currently the leading cause of cancer-related deaths worldwide. Significant improvements in lung cancer therapeutics have relied on a better understanding of lung cancer immunity and the development of novel immunotherapies, as best ex
Externí odkaz: https://doaj.org/article/3f64b5a2cd1a421099355b2b9704a1c9
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3
Akademický článek
Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice
Autor: David L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. Kulkarni, Michael K. Longmire, Ana M. Jaramillo, Rosha P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. Lei, David P. Huston, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitiz
Externí odkaz: https://doaj.org/article/dd1b05bdffe9477f901fdf3109e68501
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4
Akademický článek
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
Autor: Xian-De Liu, Wen Kong, Christine B. Peterson, Daniel J. McGrail, Anh Hoang, Xuesong Zhang, Truong Lam, Patrick G. Pilie, Haifeng Zhu, Kathryn E. Beckermann, Scott M. Haake, Sevinj Isgandrova, Margarita Martinez-Moczygemba, Nidhi Sahni, Nizar M. Tannir, Shiaw-Yih Lin, W. Kimryn Rathmell, Eric Jonasch
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumo
Externí odkaz: https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
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6
Akademický článek
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.
Autor: Ritesh Kumar, Jennifer L Herold, Deborah Schady, Jennifer Davis, Scott Kopetz, Margarita Martinez-Moczygemba, Barbara E Murray, Fang Han, Yu Li, Evelyn Callaway, Robert S Chapkin, Wan-Mohaiza Dashwood, Roderick H Dashwood, Tia Berry, Chris Mackenzie, Yi Xu
Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006440 (2017)
Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important clinical implications, and yet little is known about the role of Sg in the development of
Externí odkaz: https://doaj.org/article/b895a95a26594da3ac13567ecd1beefe
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8
Akademický článek
Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.
Autor: Yanyu Wang, Sarah A Jenkins, Chunfang Gu, Ankita Shree, Margarita Martinez-Moczygemba, Jennifer Herold, Marina Botto, Rick A Wetsel, Yi Xu
Publikováno v: PLoS Pathogens, Vol 12, Iss 6, p e1005678 (2016)
Spores of Bacillus anthracis, the causative agent of anthrax, are known to persist in the host lungs for prolonged periods of time, however the underlying mechanism is poorly understood. In this study, we demonstrated that BclA, a major surface prote
Externí odkaz: https://doaj.org/article/40555b242b6d42bdb8d76604a7c0de0e
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