Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Margarita Martin"'
Autor:
Jyotsna Bhat-Ambure, Pravin Ambure, Eva Serrano-Candelas, Cristina Galiana-Roselló, Ariadna Gil-Martínez, Mario Guerrero, Margarita Martin, Jorge González-García, Enrique García-España, Rafael Gozalbes
Publikováno v:
Cancers, Vol 15, Iss 15, p 3817 (2023)
The study presents ‘G4-QuadScreen’, a user-friendly computational tool for identifying MTDLs against G4s. Also, it offers a few hit MTDLs based on in silico and in vitro approaches. Multi-tasking QSAR models were developed using linear discrimina
Externí odkaz:
https://doaj.org/article/43519b29daa042f7a079fbf531b871c2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the differen
Externí odkaz:
https://doaj.org/article/7d144a92e9194fe0b2111c36039c01e3
Autor:
Elizabeth Proaño-Pérez, Laia Ollé, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Muñoz-Cano, Margarita Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3515 (2023)
Activating mutations in KIT (CD117) have been associated with several diseases, including gastrointestinal stromal tumors and mastocytosis. Rapidly progressing pathologies or drug resistance highlight the need for alternative treatment strategies. Pr
Externí odkaz:
https://doaj.org/article/7fd1b6ffea5b4d7eab728aacf5e20c57
Autor:
Elizabeth Proaño-Pérez, Eva Serrano-Candelas, Cindy Mancia, Arnau Navinés-Ferrer, Mario Guerrero, Margarita Martin
Publikováno v:
Cancers, Vol 14, Iss 24, p 6198 (2022)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Gain of function in receptor tyrosine kinases type III, KIT, or PDGFRA drives the majority of GIST. Previously, our group reported that sile
Externí odkaz:
https://doaj.org/article/e5ba79af3fd04b69ae60854466bcaa3a
Autor:
Rosa Muñoz-Cano, Clara San Bartolome, Rocío Casas-Saucedo, Giovanna Araujo, Sonia Gelis, Maria Ruano-Zaragoza, Jordi Roca-Ferrer, Francis Palomares, Margarita Martin, Joan Bartra, Mariona Pascal
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58
Externí odkaz:
https://doaj.org/article/c6d0937bcefa4542ac97a8a1eba47ac7
Autor:
Margarita Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3570 (2022)
The main goal of this Special Issue was to highlight the recent advances made on the role of mast cells (MCs) in host defense and pathology [...]
Externí odkaz:
https://doaj.org/article/d8f7b7609ace428ca346f0d14a255766
Autor:
Eva Serrano‐Candelas, Erola Ainsua‐Enrich, Arnau Navinés‐Ferrer, Paulo Rodrigues, Alfonso García‐Valverde, Sarah Bazzocco, Irati Macaya, Joaquín Arribas, César Serrano, Joan Sayós, Diego Arango, Margarita Martin
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1383-1397 (2018)
Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatm
Externí odkaz:
https://doaj.org/article/44732c850c0545fbb2a5fcb190e1048f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4935 (2021)
Anaphylaxis is a severe allergic reaction, rapid in onset, and can lead to fatal consequences if not promptly treated. The incidence of anaphylaxis has risen at an alarming rate in past decades and continues to rise. Therefore, there is a general int
Externí odkaz:
https://doaj.org/article/5c20a30c9c8c4a3098cb660c0fe009e4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5203 (2021)
Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect o
Externí odkaz:
https://doaj.org/article/13d080342919453897298a7907b1e201
Autor:
Eva Serrano-Candelas, Rubén Martínez-Aranguren, Olga Vega, Gabriel Gastaminza, Joan Bartra, Maria Teresa Audicana, Jorge M. Núñez-Córdoba, Jaime Algorta, Antonio Valero, Margarita Martin, Marta Ferrer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb’s mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rap
Externí odkaz:
https://doaj.org/article/995bf92164984868a3e21c2d3ca0244e