Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Margarita Kamenetsky"'
Autor:
Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3251 (2008)
Mammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases. Genetic deletion of the second through fourth coding exo
Externí odkaz:
https://doaj.org/article/c2df02c708ae44928649b122d1d5d41e
Publikováno v:
The Journal of General Physiology
In β cells, both glucose and hormones, such as GLP-1, stimulate production of the second messenger cAMP, but glucose and GLP-1 elicit distinct cellular responses. We now show in INS-1E insulinoma cells that glucose and GLP-1 produce cAMP with distin
Autor:
Clemens Steegborn, Erin M. Bank, Lonny R. Levin, Jochen Buck, Sabine Middelhaufe, Margarita Kamenetsky
Publikováno v:
Journal of Molecular Biology. 362:623-639
The second messenger cAMP has been extensively studied for half a century, but the plethora of regulatory mechanisms controlling cAMP synthesis in mammalian cells is just beginning to be revealed. In mammalian cells, cAMP is produced by two evolution
Autor:
Jochen Buck, Jonathan H. Zippin, Kenneth C. Hess, Lonny R. Levin, Margarita Kamenetsky, A. Stessin
Publikováno v:
Journal of Biological Chemistry. 281:17253-17258
Nerve growth factor (NGF) and the ubiquitous second messenger cyclic AMP (cAMP) are both implicated in neuronal differentiation. Multiple studies indicate that NGF signals to at least a subset of its targets via cAMP, but the link between NGF and cAM
Autor:
Kenneth C. Hess, Susan S. Suarez, Becky Marquez, Catarina Miyamoto, Gregory S. Kopf, Stuart B. Moss, Jochen Buck, Brian H. Jones, Teri Ord, Jonathan H. Zippin, Lonny R. Levin, Margarita Kamenetsky, Yanqiu Chen, Carmen J. Williams
Publikováno v:
Developmental Cell. 9(2):249-259
SummaryMammalian fertilization is dependent upon a series of bicarbonate-induced, cAMP-dependent processes sperm undergo as they “capacitate,” i.e., acquire the ability to fertilize eggs. Male mice lacking the bicarbonate- and calcium-responsive
Autor:
Narinder Gautam, Kenneth C. Hess, Noah Nathan, Olivia Lou, Carl Nathan, A. Stessin, Lonny R. Levin, Jochen Buck, Hyunsil Han, Margarita Kamenetsky, Julia Roberts, William A. Muller, Edward Hyde
Publikováno v:
The Journal of Experimental Medicine
Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox
Autor:
Jochen Buck, Kenneth C. Hess, Jeanne Farrell, David R Huron, Margarita Kamenetsky, Jonathan H. Zippin, Lonny R. Levin, Donald A. Fischman
Publikováno v:
The Journal of Cell Biology
Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of
Publikováno v:
Journal of Biological Chemistry. 278:15922-15926
“Soluble” adenylyl cyclase (sAC) is a widely expressed source of cAMP in mammalian cells that is evolutionarily, structurally, and biochemically distinct from the G protein-responsive transmembrane adenylyl cyclases. In contrast to transmembrane
Autor:
Alexandra Kaganovich, John DeSilva, Margarita Kamenetsky, Pak P. Poon, Gerald C. Johnston, Hong Sun, Bradford Maynes, Ludmilla Berenfeld, Jennifer L. Collins, Irina Ratskovskaya, Jennifer Heymont, JoAnne Engebrecht, Aaron Moulin, Gregory A. Petsko
Publikováno v:
Proceedings of the National Academy of Sciences. 97:12672-12677
PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway.
Publikováno v:
The Journal of biological chemistry. 278(18)
"Soluble" adenylyl cyclase (sAC) is a widely expressed source of cAMP in mammalian cells that is evolutionarily, structurally, and biochemically distinct from the G protein-responsive transmembrane adenylyl cyclases. In contrast to transmembrane aden